How inflammation affects JAK2‑mutant blood cells
Effect of inflammation on JAK2 mutant evolution in the hematopoietic system: mathematical models and experiments
This project looks at whether inflammation helps JAK2‑mutant blood cells grow in people with early myeloproliferative neoplasms and could point to ways to slow disease progression.
Quick facts
| Grant type | R37 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California-Irvine NIH-funded |
| Lab location | 1 site (Irvine, United States) |
| Project ID | NIH-11473217 on NIH RePORTER |
What this research studies
I want to know whether inflammation changes how blood cells carrying the JAK2 mutation expand and compete with normal cells. The team will combine laboratory experiments on cells and biological models with mathematical modeling to track mutant versus wild-type cell behavior. Their goal is to see if altering inflammation can shift the evolutionary fate of JAK2‑mutant cells and delay progression to myelofibrosis or acute leukemia. This is primarily lab and modeling work that could guide future patient-focused therapies but is not itself a clinical treatment trial.
Who could benefit from this research
Good fit: People with early-stage myeloproliferative neoplasms who carry the JAK2V617F mutation would be the most relevant group for this research.
Not a fit: People without JAK2 mutations or those with advanced myelofibrosis or established acute leukemia are less likely to benefit directly from this project.
Why it matters
Potential benefit: If successful, this work could lead to new ways to slow or prevent progression of early MPN and reduce the risk of myelofibrosis or AML.
How similar studies have performed: Preliminary lab and modeling data indicate inflammation can favor JAK2‑mutant cell growth, but using that insight to alter disease progression is a novel and unproven approach.
Where this research is happening
Irvine, United States
- University of California-Irvine — Irvine, United States (Active)
Researchers
- Principal investigator: Fleischman, Angela Goffredo — University of California-Irvine
- Study coordinator: Fleischman, Angela Goffredo
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.