Clinical trial Recruiting at 1 site Observational Ages 18 and up

Evaluating non-invasive imaging techniques for blood flow assessment

Official title: A Pilot Study to Evaluate Multi-Spectral Imaging (MI) and Laser Speckle Imaging (LSI) and Multiphoton Microscopy (MPM) During Vascular Occlusion

Run by University of California, Irvine · NCT01484730 · Data updated 2026-11-12

This study is testing new non-invasive imaging techniques to see how well they can measure blood flow changes in the skin when a pressure cuff is applied.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment150 (estimated)
SponsorUniversity of California, Irvine
Academic / other
Locations1 site (Irvine, California)
StatusRecruiting
StartedNovember 2011
Main results expectedAugust 2026
Study endsAugust 2028
Registry record updatedDecember 10, 2025
Trial IDNCT01484730 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates include adult males and females aged 18 years and older with no pregnancy status.

Probably not a fit

Patients under 18 years of age or those who are pregnant will not benefit from this study.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This research evaluates the performance of non-invasive imaging modalities, specifically Multi-Spectral Imaging and Laser Speckle Imaging, to assess skin blood flow dynamics during vascular occlusion. A pressure cuff will be applied to stimulate changes in blood flow, allowing researchers to measure vascular conditions ranging from ischemia to hyperemia. The study aims to establish the feasibility of these imaging technologies in detecting variations in hemoglobin concentration and blood flow in the skin.

Why it matters

Potential benefit: If successful, this study could enhance non-invasive diagnostic techniques for assessing vascular conditions, leading to better patient management.

How similar studies have gone: While this approach is innovative, similar imaging techniques have shown promise in other studies, suggesting potential for success.

Who can join: the full rules

Show full inclusion / exclusion criteria
Inclusion Criteria:

* Male and female adult 18 years and older

Exclusion Criteria:

* Younger than 18 years of age
* Pregnant women

Where it's running

  • Beckman Laser Institute and Medical Clinic
    Irvine, California, United States
    Recruiting

Study contacts

  • Principal investigator: Anthony Durkin, PhD — University of California, Irvine
  • Study coordinator: Gordon Kennedy, PhD
  • Email: gordon.kennedy@uci.edu
  • Phone: 949-824-4713

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.