Comparing short and long antibiotic courses for severe skin infections

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study evaluates the safety of a shorter course of antibiotics (48 hours) compared to a longer course (7 days) for patients with necrotizing soft tissue infections (NSTI) after achieving source control. It aims to determine if the shorter duration has similar risks of morbidity and mortality as the longer course. The study also seeks to correlate serum procalcitonin levels with the resolution of systemic infection in these patients. By potentially reducing antibiotic use, the study may help mitigate costs and adverse effects associated with prolonged antibiotic therapy.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Adult patients 18 years of age or older with all following criteria:
* Presenting to the Emergency Department with history, exam and/or imaging concerning NSTI, AND
* Patients who undergo consultation by the Emergency General Surgery service, AND
* Patients included must have skin or soft tissue findings consistent with NSTI (erythema, crepitus, or pain out of proportion to exam), AND
* Systemic signs of infection including fever (temperature \>38.0°C) or leukocytosis (≥11,000 peripheral white cells per cubic millimeter), AND
* Patients who undergo excisional debridement and/or amputation to achieve source control.

Exclusion Criteria:

* Pregnant patients
* Prisoners
* Patients with bacteremia upon admission
* Patients unable to provide consent (including no legally authorized representative)

Where it's running

• University of California Irvine Medical Center
  Orange, California, United States Recruiting

Study contacts

• Principal investigator: Areg Grigorian, MD — University of California, Irvine
• Study coordinator: Areg Grigorian, MD
• Email: agrigori@hs.uci.edu
• Phone: 8184389093

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

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• Using blue light to improve immune response in patients with infections

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.