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Clinical trials and research at Northwestern University
As of November 12, 2026, Find a Trial lists 147 clinical trials run by Northwestern University that are recruiting, at sites in 4 countries (most in United States (146), Nigeria (1), Thailand (1)). 3 were first registered in the last 30 days. By phase: Phase 2 (19), Early Phase 1 (8), Phase 4 (7), Phase 3 (5). There are also 968 NIH-funded research projects at this institution, with $619.3 million in listed awards. Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 147Clinical trials
- 968NIH research projects
- 3New in 30 days
- 4Countries
Newest trials
All recruiting trials (147)
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Fathers and Babies: A program to help dads and support partners
This study tests the Fathers and Babies (FAB) program to see if it can improve mental health for fathers and help them support their partners, delivered through home-visiting services in Illinois and Texas.
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Shouldice groin hernia repair: permanent vs slowly dissolving stitches
We’re testing whether slowly dissolving stitches (PDS) work as well as permanent stitches (Prolene) for adults with a non-mesh Shouldice inguinal hernia repair.
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Duramesh repair versus minimally invasive IPOM for high-risk umbilical hernia
This trial tests whether Duramesh repair can match the pain outcomes of minimally invasive IPOM in adults with high-risk umbilical or ventral hernias.
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Psychological prehabilitation for complex GI surgery
A preoperative, structured psychological program called PREPARE-GI is tested to see if it helps adults with prior medical trauma undergoing complex GI surgery feel less stress, anxiety, and depression and recover better.
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Testing different stipend schedules and a mobile program to help adults with binge eating and food insecurity
This study tests whether varying ways of paying participants and access to a mobile tool can help adults who binge eat and have limited food security.
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Epidural vs. opioid-sparing pain control after complex ventral hernia repair
This trial tests whether an epidural for pain relief after transversus abdominis release hernia repair works better than a non‑opioid, abdominal wall numbing injection approach.
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Family Navigator Plus for Foster Parents (FN+)
A 5-week program helps foster parents understand and support their youth’s mental health and connect to services.
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Music-based approach to reduce anxiety in Alzheimer's patients and support caregivers
This study tests whether Clinically Designed Improvisatory Music can lower anxiety in people with Alzheimer's and anxiety, and whether it eases caregiver burden.
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SMAD4-tailored neoadjuvant therapy for pancreatic cancer that can be surgically removed
This trial tests whether using SMAD4 mutation status can guide pre-surgery chemotherapy for patients with resectable or borderline resectable pancreatic ductal adenocarcinoma.
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Medication Collaboration for Dementia: A Feasibility Study
This study tests a short, joint medication-management session for people 60+ with early dementia or mild cognitive impairment and their family caregivers to see if it’s workable and helps with taking medicines and beliefs about dementia and independence.
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Healthy Options At Pantries prompts healthier online pantry choices
A digital nudge called HOAP is tested in online food pantries to see if it helps shoppers pick healthier items.
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Ocrevus Zunovo in Multiple Sclerosis: Real‑World Use and Patient Feedback
This study tests how well Ocrevus Zunovo works in real-life MS care, looking at how patients tolerate it, stay on treatment, and what affects access and satisfaction.
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Cancer Care Navigation: Connecting Chicago Adults to Screenings and Care
This study tests three patient navigation approaches to help adults in Chicago overcome barriers to cancer screening and care.
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Does extra family income improve child mental health and brain biology in low-income families?
This study tests whether three years of extra income for parents can improve their child’s mental health and neuroimmune function.
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HPV prevention support for U.S. Vietnamese families
This pilot tests four digital components to help U.S. Vietnamese parents decide to vaccinate their adolescents against HPV.
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Magneto 150 vs MOSES 2.0 for HoLEP in Benign Prostatic Hyperplasia
This trial tests whether the Magneto 150 holmium laser can shorten intraoperative bleeding time compared with MOSES 2.0 during HoLEP for enlarged prostate.
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Jeeejaculatory-Sparing HoLEP for Uprating Ejaculation During Prostate Surgery
A new ejaculatory-sparing HoLEP procedure is being tested to see if it can preserve ejaculation while treating enlarged prostate with urinary symptoms.
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Effects of Transcutaneous Vagal Nerve Stimulation on Return to Consciousness After Surgery
This study tests whether noninvasive tcVNS can help people wake up faster after surgery and reduce delirium and depression in the recovery period.
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Parents and Babies: a virtual and hybrid program to support perinatal mood for LGBTQ+ parents
A pilot program tests a Parents and Babies intervention to see if it’s feasible, acceptable, and potentially helpful for LGBTQ+ people who are pregnant or within a year postpartum and have mild depressive symptoms.
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See if anti-estrogen therapy can help men with a unilateral inguinal hernia
This small early-stage trial tests whether anti-estrogen medications can be used in men 50 and older with a symptomatic unilateral inguinal hernia to see if they are safe and feasible.
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BMS-986504 plus pemetrexed for MTAP-deleted metastatic solid tumors
This study tests whether the combination of BMS-986504 and pemetrexed is safe and potentially effective for people with MTAP-deleted metastatic solid tumors.
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Ablative Dose Testing for Y-90 Radiation Segmentectomy in Liver Cancer
This study tests the best Y-90 radiation dose to fully ablate liver tumors in adults who can’t be removed or treated with standard methods.
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Flexible online mindfulness program for pediatric residents
This program will test whether letting pediatric residents choose a 3-, 5-, or 7-week online mindfulness course improves engagement, satisfaction, and completion compared with being assigned a length.
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REACH-OUT: A technology-based approach to improve blood pressure in reproductive-age women at community clinics
This trial tests a technology-enabled strategy to help young women with hypertension manage their BP and adhere to blood pressure medications in Federally Qualified Health Centers.
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Genicular Artery Embolization for Knee Osteoarthritis
This study tests whether Genicular Artery Embolization can relieve knee pain in adults with mild-to-moderate knee osteoarthritis who have tried standard treatments.
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How the way doctors explain epidural steroid injections affects sciatica pain outcomes
This trial will test whether explaining epidural steroid injections more positively or more neutrally changes pain for adults with lumbosacral radiculopathy who are candidates for injections.
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Northwestern Neuromuscular Disease Biobank
This project will collect blood, skin, spinal fluid, and clinical information from adults with neuromuscular diseases seen at Northwestern to create a shared resource for research.
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Watchful waiting versus immediate repair for a hidden hernia on the other side of the groin
This trial will test whether fixing a small, hidden hernia found on the opposite side during minimally invasive groin hernia surgery or leaving it alone is better for adults having unilateral symptomatic inguinal hernia repair.
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Selenium supplements for moderate-to-severe ulcerative colitis on advanced therapies
This trial will see if taking 200 mcg of selenomethionine daily helps adults with moderate-to-severe ulcerative colitis who are starting or switching biologics or other advanced therapies.
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Sleep and lucid dreaming with virtual reality to support mental health
This trial will test whether a Dream-Yoga-inspired program delivered with virtual reality and home sleep technology can increase lucid dreaming and help reduce anxiety in adults who remember dreams at least once a week.
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Brain signals that reveal how people identify different smells
This research will test whether brain signals recorded from people having epilepsy surgery show patterns that match how they perceive different smells.
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Text messaging safety plan for young adults with suicidal thoughts
A text-message safety planning program is being tested to see if it’s doable and acceptable for young adults with recent suicidal thoughts.
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Progressive Resistance Training First to Help AF and HFpEF Patients Feel Better
This trial tests whether starting with progressive resistance training before aerobic exercise can improve exercise capacity and quality of life in people aged 60 and older who have atrial fibrillation and HFpEF.
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PREcision MEDicine In Achalasia: How Long to Cut During POEM
This study looks at whether pre-procedure tests can help doctors decide how long to cut the esophageal muscle during POEM for adults with certain swallowing disorders.
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Shorter POEM vs longer POEM for achalasia and EGJOO
A 3-phase randomized trial tests whether a shorter 4 cm POEM works as well as the standard 9 cm POEM for easing swallowing difficulties in adults with type I/II achalasia or EGJ outflow obstruction.
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Web-based CONNECT toolkit to reduce emotional distress and anxiety in rural older cancer survivors
We will test whether CONNECT, a web-based toolkit, can help reduce cancer-related emotional distress and anxiety in rural adults over 65 who have finished cancer treatment.
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Misoprostol to lower fluid absorption during hysteroscopic myomectomy
This trial will test whether a single rectal dose of misoprostol given before hysteroscopic myomectomy reduces the amount of fluid absorbed during the procedure in women with 1–3 cm uterine fibroids.
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N-803 for progressive synovial sarcoma and myxoid/round cell liposarcoma after TCR-T therapy
This trial tests whether N-803 can safely boost lingering TCR-T immune cells and help people whose synovial sarcoma or myxoid/round cell liposarcoma has progressed after prior TCR-T treatment.
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Comparing three ways to help toddlers with developmental delays learn to communicate
We are testing three different early intervention approaches to see which helps toddlers with developmental delays improve their communication the most.
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Ublituximab (Briumvi) for early relapsing MS
This study will test whether giving Ublituximab (Briumvi) about twice a year is safe and changes a blood marker (neurofilament light) in adults with early relapsing MS.
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Embedded emergency department physical therapy for dizziness
This project will test whether placing a physical therapist directly in the emergency department helps adults with dizziness get faster, more targeted care than usual ED care.
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Embedded emergency department physical therapy for adults with recent low back pain
This project tests placing a physical therapist directly in the emergency department to see if it improves care for adults who come in with recent low back pain.
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Digital tool for teens to help stop NSSI
A small study will test a teen-focused app that delivers a guided digital program to see if it’s feasible for teens 14–18 who currently hurt themselves but aren’t in therapy.
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Ocrelizumab and GLP‑1 agonists in people with multiple sclerosis
This project will see if taking GLP‑1 weight‑loss medicines while on ocrelizumab changes progression of disability in adults with multiple sclerosis.
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Lowering neck radiation dose in HPV-related oropharyngeal cancer
This trial tests whether giving a lower dose of radiation to the elective neck lymph nodes while treating the primary tumor can maintain good cancer control with fewer side effects in adults with HPV-related oropharyngeal cancer.
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Personalized theta-burst stimulation to create lasting changes in approach and avoidance behavior
This study will test whether personalized theta-burst magnetic stimulation, timed to each person's brain theta rhythm, can produce lasting changes in approach and avoidance behavior in healthy adults.
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Pediatricians Building Resilience by Early Identification for Toddler Well-Being
This program tests a parenting support online tool (FCU-O) for caregivers of toddlers at risk of mental health challenges to see if it helps improve child behavior and caregiving practices.
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How different parts of the human amygdala respond to smells
This study will test whether different amygdala subregions in adults respond differently to odors when measured with fMRI.
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Human olfactory amygdala subregions and their responses to smells
This research will test how different parts of the human amygdala respond to smells by presenting odors while recording and stimulating brain activity in adults.
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Cemiplimab treatment for incurable metastatic or unresectable NUT carcinoma
This trial will test whether the immunotherapy drug cemiplimab can help people whose NUT carcinoma has spread or cannot be removed by surgery.
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Zanzalintinib for advanced liver cancer after prior treatment
This phase Ib/II study tests if zanzalintinib is safe and tolerable and if it can help people with advanced liver cancer after other therapies.
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MINT Conditioning to Improve Gait
A myoelectric interface training is being tested to see if it can help adults with leg weakness from stroke walk better.
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Using a needle-free device for numbing skin during paracentesis in liver cirrhosis patients
This study is testing a needle-free device to see if it can make the skin numbing process more comfortable for adults with liver cirrhosis who need a procedure to remove fluid from their abdomen.
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Using a wireless ANNE One vital-sign device array to reduce bedside vital-sign measurement time
This trial will see if using a wireless Bluetooth ANNE One vital-sign device array reduces the time staff spend obtaining and charting vital signs for adult inpatients on a general medical floor.
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Smart Band-Aid to See If AI-Powered Pain Scores Match How Women Feel Pain
This study tests whether a microneedle patch and a smartwatch can align AI-derived pain scores with how women with chronic pain rate their own pain.
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Culturally adapted mindfulness program to reduce stress for African American adults with high blood pressure and depression
This program will test whether an 8-week, group-based, culturally adapted mindfulness course helps African American adults with high blood pressure and depression reduce depressive symptoms and improve blood pressure control.
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Family Navigator Plus: a 5-week education program for foster parents
This 5-week program tests whether Family Navigator Plus helps foster parents of 6–17-year-olds better understand their child's mental health needs and find appropriate services.
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Single-session intervention to change ambiguity aversion
This trial tests whether one brief intervention can change how adults with intolerance of uncertainty and anxiety make ambiguous decisions and how their brains respond.
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Improving outcomes for stem cell transplant patients using an intervention website
This study is testing if a special website can help adults with blood cancer feel better and improve their quality of life after a stem cell transplant compared to a regular educational website.
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XL092 (zanzalintinib) for locally advanced or metastatic radioiodine‑refractory differentiated thyroid cancer
This trial tests whether XL092 (zanzalintinib), an oral tyrosine kinase inhibitor, can keep radioiodine‑refractory differentiated thyroid cancer from getting worse in adults with locally advanced or metastatic disease.
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Pupil light-response testing for delayed sleep-wake phase disorder
This study tests whether people with delayed sleep-wake phase disorder have different pupil responses to light and whether a single dose of citalopram increases light-induced melatonin suppression.
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Antenatal navigator support to improve pregnancy and newborn health
This trial will test whether giving low-income pregnant people a dedicated antenatal navigator from early pregnancy through two weeks after birth improves their health, their newborns' health, care experiences, and use of health services.
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Personalizing adult heart transplant immunosuppression using blood microRNA levels
This project will try to use blood microRNA patterns to monitor immune status in adults after heart transplant and predict who will develop infection or rejection.
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Breathing training to improve sleep apnea and cognitive function
This study tests whether breathing training can help people with sleep apnea sleep better and think more clearly.
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Using shockwave therapy to treat breast reconstruction fibrosis
This study tests whether shockwave therapy can help women with breast reconstruction reduce scarring and improve their recovery after surgery.
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Visual education tool to help postpartum first-time mothers recognize urgent warning signs
This project will test whether a simple picture-based education tool helps first-time English-speaking postpartum mothers recognize and report urgent maternal warning signs.
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Predicting smell recovery in patients with nasal polyps treated with dupilumab
This study is trying to see if certain factors can help predict how well people with nasal polyps will recover their sense of smell after being treated with dupilumab.
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Improving understanding and treatment of swallowing difficulties
This study is testing how well a new treatment can help people with swallowing difficulties and related symptoms by looking at how their esophagus works.
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Combining interventions to address HIV in Nigerian youth
This study is testing two different ways to help young people in Nigeria, aged 15-24, get tested for HIV and stick to their treatment to manage the virus better.
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Investigational scan for detecting recurrent prostate cancer
This study is testing a new imaging technique to see if it can help find prostate cancer in men whose PSA levels are rising after treatment but who had a negative result on their last scan.
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Investigating how the brain represents odor intensity
This study is trying to understand how our brains recognize the strength of different smells and how that differs from their actual concentration.
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Epcoritamab and Lenalidomide for Refractory or Relapsed Immunodeficiency-Related Large B-Cell Lymphoma
This phase 2 trial checks if the combination of epcoritamab and lenalidomide can help people with immune-related large B-cell lymphoma that hasn’t responded to treatment or has come back.
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Comparing liver transplant methods for colorectal cancer patients
This study is testing different liver transplant methods for colorectal cancer patients to see which one helps them recover faster and live longer after the surgery.
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Investigating sleep and cognition in older adults with insomnia
This study tests how a new light therapy can improve sleep and thinking skills in older adults with insomnia, who are at risk for memory problems.
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Helping people walk better after leg revascularization for peripheral artery disease
This project will see if adding a home-based walking program or taking nitrate-rich beetroot juice after leg revascularization helps people with peripheral artery disease walk farther and faster.
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Upadacitinib for eyelid dermatitis in adults
This study tests whether upadacitinib can help adults with eyelid dermatitis that hasn’t improved after standard creams.
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Evaluating the effectiveness of robotic-assisted bronchoscopy for lung nodule biopsy and staging
This study is testing if using robotic-assisted bronchoscopy with ultrasound helps doctors better and faster diagnose lung nodules to improve treatment outcomes.
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Investigating Tizanidine's effects on arm movement in stroke patients
This study is testing if the medication Tizanidine can help stroke patients improve their arm movements.
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Exercise and Nitric Oxide Effects in Peripheral Artery Disease
This study is testing if a 12-week exercise program can boost nitric oxide levels in people with Peripheral Artery Disease and whether drinking beetroot juice can help those who don't see improvements from exercise.
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Evaluating Sodium Butyrate's Effect on Menstrual Symptoms in Women
This study is testing if taking Sodium butyrate every day can help women with painful menstrual symptoms feel better over 12 weeks.
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Using pemetrexed to treat metastatic bladder cancer and other solid tumors with specific gene mutations
This study is testing if the drug pemetrexed can help people with advanced bladder cancer and other solid tumors that have certain gene mutations.
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Comparing two methods of knee replacement surgery
This study is testing two different knee replacement surgery techniques to see which one makes patients feel better and have better results after their operation.
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Ketamine, stellate ganglion block, or both for TBI-related headache and PTSD
This trial will try ketamine infusions, a stellate ganglion block, or both to see if they reduce headaches and PTSD symptoms in adults with traumatic brain injury and/or PTSD.
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Mapping brain activity during shoulder movement in stroke patients
This study is testing how the brain works during shoulder movements in stroke survivors to find new ways to help them regain control of their movements.
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Zanzalintinib treatment for advanced leiomyosarcoma
This study is testing if a new medication called zanzalintinib can help people with advanced leiomyosarcoma live longer without their cancer getting worse.
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Identifying microRNAs to improve heart transplant outcomes in children
This study is trying to find specific microRNAs in the blood of children who have had heart transplants to see if they can help predict infections and rejection of the new heart.
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Identifying heart tissue changes in patients with heart failure
This study looks at changes in heart tissue of people with heart failure to see if it can help find better treatments for their condition.
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AI-powered ECG to detect heart disease and atrial fibrillation in routine care
This trial tests whether an AI-based ECG tool can help doctors find undiagnosed heart disease and atrial fibrillation in patients and whether using the tool changes clinical decisions and outcomes.
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Combining relugolix and enzalutamide with radiation therapy for very high risk prostate cancer
This study is testing if combining two medications, relugolix and enzalutamide, with radiation therapy can help men with very high risk prostate cancer live longer and feel better.
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Surgery for lung cancer after initial treatment
This study is testing if a specific lung surgery called segmentectomy can be safely performed on patients with non-small cell lung cancer who have improved after initial treatment.
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Measuring Blood Pressure in Pregnant Women Using Different Cuffs
This study is testing if a special forearm cuff gives more accurate blood pressure readings for pregnant women compared to a regular upper arm cuff, especially for those who are very overweight.
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Triapine plus temozolomide for recurrent glioblastoma
This trial tests whether adding the drug triapine to temozolomide helps people with recurrent IDH‑wildtype glioblastoma.
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Using light therapy to enhance walking in patients with peripheral artery disease
This study is testing if daily light therapy can help people with peripheral artery disease walk farther and improve their overall health when combined with home exercises.
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Using Fisetin to Improve Walking in Patients with Peripheral Arterial Disease
This study is testing if Fisetin can help people with peripheral artery disease walk better by reducing certain old cells in their bodies.
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Mobile health intervention for managing high blood pressure in emergency departments
This study is testing a mobile health program to see if it can help people with high blood pressure who visit the emergency room manage their condition better than regular care.
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Assessing the impact of ureteral rest duration before surgery for ureteral stricture
This study is trying to see if the length of time a ureter is rested before surgery can affect how long the ureteral strictures are in adults who are about to have surgery for this condition.
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Using virtual reality to reduce pain during knee procedures
This study tests if using virtual reality can help reduce pain and improve satisfaction for patients getting knee procedures compared to just sedation alone.
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Proton therapy combined with standard radiation for treating retroperitoneal sarcoma
This study is testing a new type of radiation therapy combined with standard treatment to see if it helps people with newly diagnosed retroperitoneal sarcoma before they have surgery.
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Comparing two surgical methods for removing uterine septum
This study is testing two different surgical methods for removing a uterine septum to see which one works better and has fewer complications.
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Comparing two types of spacers for treating knee joint infections
This study is testing which type of spacer works better for treating knee joint infections in patients who have had knee replacement surgery.
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Investigating Pain Treatments for Knee Osteoarthritis
This study is testing whether the pain medications duloxetine and celecoxib can help people with knee osteoarthritis feel better compared to a placebo.
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Using PET scans to guide radiation therapy for metastatic prostate cancer
This study is testing if using PET scans to guide radiation therapy can help men with metastatic prostate cancer live longer and have better treatment outcomes compared to standard treatments alone.
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A wearable device to assess eating behaviors in everyday life
This study tests a new wearable device that helps people track their eating habits in real life while keeping their privacy safe.
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Using OTC hearing aids to improve communication in older adults with mild cognitive impairment
This study is testing if Over-the-Counter hearing aids can help older adults with mild cognitive impairment communicate better compared to just using communication tips.
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Fresh frozen plasma for moderate-to-severe traumatic brain injury (FIT-BRAIN)
This trial will try adding two units of fresh frozen plasma to standard care in adults 18–65 with moderate to severe TBI to see if it is safe and improves short- and longer-term brain and functional outcomes.
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Elacestrant with or without a CDK4/6 inhibitor for ER+/HER2- advanced or metastatic breast cancer
This study will test whether adding a CDK4/6 inhibitor to elacestrant helps people with ER-positive, HER2-negative advanced or metastatic breast cancer who have an ESR1 mutation and prior CDK4/6 exposure.
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Exercise and beetroot juice for improving walking in patients with PAD
This study is testing whether combining treadmill and home exercises with beetroot juice can help older patients with peripheral artery disease walk farther and feel better.
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Fasting regimen for women undergoing chemotherapy after surgery for gynecologic cancers
This study is testing if an alternate day fasting diet can help women with ovarian and endometrial cancers feel better during chemotherapy and improve their quality of life.
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Using hyperbaric oxygen therapy to treat ulcerative colitis
This study is testing whether hyperbaric oxygen therapy can help hospitalized patients with ulcerative colitis feel better and reduce the need for stronger treatments.
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Collecting health outcomes from robotic esophagectomy procedures
This study is collecting health information from patients who have robotic esophagectomy surgery to see how it affects their recovery and overall health.
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Improving care for men with benign prostatic hyperplasia using patient feedback
This study is testing if using feedback from men with benign prostatic hyperplasia can help doctors provide better care and improve their quality of life by focusing on a wider range of symptoms.
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Combining WP1066 with radiation therapy for newly diagnosed glioblastoma
This study is testing if adding a new drug called WP1066 to regular radiation therapy can help people with newly diagnosed glioblastoma live longer and feel better.
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HeartShare combines various data to improve heart failure treatment
This study is trying to see if using different types of health data can help doctors create better, personalized treatments for people with heart failure.
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Using advanced imaging to detect prostate cancer in men eligible for active surveillance
This study is testing a new type of imaging to see if it can better find serious prostate cancer in men who are being monitored for low-risk disease.
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Combining a topical treatment with radiation for skin lymphoma
This study is testing if using a skin cream along with radiation can help patients with a type of skin lymphoma that hasn't improved with regular treatments.
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AI-guided radiation therapy for lung tumors
This study is testing if using artificial intelligence to personalize radiation treatment can help people with lung tumors get better results and reduce the chance of their cancer coming back.
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Using Virtual Reality to Reduce Anxiety in Patients Getting Epidural Injections
This study tests if using virtual reality can help reduce anxiety for patients waiting to get cervical epidural steroid injections compared to standard care.
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CPI-613 combined with hydroxychloroquine and chemotherapy for advanced solid tumors
This study is testing a new combination of treatments, including CPI-613 and hydroxychloroquine, to see if it can help people with advanced solid tumors that haven't improved with other chemotherapy.
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Using Contingency Management to Treat Stimulant Use in Addiction Programs
This study is testing a new way to help people in opioid treatment programs reduce their stimulant use by using a reward system to see if it improves their care.
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Program to help cancer survivors improve health behaviors
This study is testing a new program to help cancer survivors improve their health habits, like losing weight and being more active, to see if it works better than regular care.
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Improving relationship education to reduce HIV rates among sexual and gender minorities
This study is testing a new relationship education program to see if it can help reduce HIV rates among gay, bisexual, queer, and transgender individuals who are in relationships with cisgender men.
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Registry for double lung transplants in patients with lung-limited cancers
This study is collecting information on patients with lung-limited cancers who are getting double lung transplants to see how well the procedure works for them.
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Using Dupilumab to Treat Itch in Genetic Skin Disorders
This study is testing if dupilumab can help reduce severe itching and improve quality of life for people with genetic skin disorders.
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Using beetroot juice to improve walking in patients with peripheral artery disease
This study is testing if drinking beetroot juice can help people with peripheral artery disease walk better.
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Using loop diuretics to improve same-day discharge after prostate surgery
This study is testing if giving a diuretic during prostate surgery can help men go home the same day by improving their recovery and reducing complications.
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TheraSphere and Systemic Therapy for High-Risk HCC
This study tests whether giving Yttrium-90 radiation followed by either immunotherapy or a tyrosine kinase inhibitor helps people with advanced liver cancer see more time without progression.
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Using Negative Pressure Wound Therapy to Heal Chronic Pressure Sores
This study tests if a special wound therapy can help heal serious pressure sores better than regular dressings for patients with deep wounds.
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Non-invasive monitoring of heart transplant recipients using MRI
This study is testing a new way to monitor heart transplant patients using MRI and artificial intelligence to see if it can help spot problems like rejection and improve their care.
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A tool for managing stress and improving quality of life in cancer patients
This study is testing an online program called My Wellbeing Guide to see if it can help cancer patients feel less depressed and improve their quality of life.
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Study on how lifestyle factors affect women's reproductive health before pregnancy
This study looks at how things like sleep, diet, and exercise can affect women's health and pregnancy outcomes before they become pregnant.
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Using intrathecal morphine to manage pain after lung surgery
This study is testing if a special type of morphine given directly into the spine can help reduce pain and the need for other pain medications after lung surgery.
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Improving sleep and skin symptoms in children with eczema using Dupilumab
This study is testing if the medication Dupilumab can help improve sleep and skin symptoms in children aged 6 to 17 with moderate to severe eczema.
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Testing cocoa flavanols for improving walking distance in patients with peripheral artery disease
This study is testing if cocoa flavanols can help older adults with peripheral artery disease walk farther and improve their overall mobility.
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Understanding how different parts of the human amygdala process smells
This study is trying to see how different parts of the brain help us process smells by testing various odors on people and looking at their brain activity.
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ctDNA as a biomarker to guide treatment for non-metastatic pancreatic cancer
This study tests whether measuring pancreatic cancer DNA in the blood can help doctors understand how patients respond to chemotherapy and surgery.
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Improving arm recovery after stroke using a computer interface and sleep techniques
This study is testing if combining computer training with sleep techniques can help stroke survivors improve their arm movement and recovery.
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Understanding Hearing Aid Outcomes in Older Adults with Alzheimer's Dementia
This study is testing how different hearing aid settings can help older adults with Alzheimer's dementia and memory issues understand speech better and have more successful conversations.
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Mobile app to help teens and young adults take their daily oral leukemia medicine
This project tests a smartphone app that sends tailored reminders and messages to help adolescents and young adults with acute lymphoblastic leukemia or lymphoblastic lymphoma take their daily 6-mercaptopurine during maintenance therapy.
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Exploring the microbiome in patients with cutaneous T cell lymphoma
This study looks at the gut bacteria of people with cutaneous T cell lymphoma to see how it compares to healthy individuals and if it can help us understand the disease better.
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Combining brain stimulation with cognitive training for mild traumatic brain injury
This study is testing whether combining brain stimulation with attention training can help people with mild traumatic brain injury and PTSD improve their focus and attention.
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Examining the gut and skin microbiome in vitiligo patients
This study looks at the gut and skin bacteria in people with vitiligo to see if their microbiomes are different from those without the condition.
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Using a wearable device to improve arm movement after stroke
This study is testing a special device that helps stroke survivors improve their arm movement at home to see if it works better than a fake device.
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Monitoring liver transplant recipients for early detection of complications
This study is testing if checking blood, urine, and tissue samples from liver transplant patients can help spot early signs of kidney problems, organ rejection, and Hepatitis C to improve their treatment and health outcomes.
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Monitoring kidney transplant recipients for rejection and damage
This study is trying to find better ways to monitor kidney transplant patients for signs of rejection and damage by collecting blood, urine, and biopsy samples.
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Tissue collection during breast cancer surgery
This project collects and stores tumor tissue from women having surgery for breast cancer so researchers can use the samples in future lab studies.
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Understanding language changes in primary progressive aphasia
This study is trying to understand how language skills change in people with primary progressive aphasia to help raise awareness and support future treatments.
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Collecting specimens and data for early detection and prevention of ovarian cancer
This study is trying to find better ways to detect and prevent ovarian cancer early by collecting blood and tissue samples from people at high risk.
NIH-funded research (newest 40 of 968)
Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.
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Understanding how language and social communication work in FMR1-related autism risks
A small, patient-friendly study looks at why people with FMR1 gene changes may have pragmatic language difficulties, which are common in autism and related conditions.
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Transformative patient navigation interventions for cancer care in diverse communities
A nationwide cancer center is testing new, community-driven ways to help people with cancer navigate care and information, especially where access is challenging.
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Microbial Dysbiosis and Its Role in Pancreatic Cancer
A doctor-researcher team at Northwestern University is studying how gut bacteria influence pancreatic cancer and its response to immunotherapy to find new ways to help patients.
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Point-of-care AQP4 antibody test to diagnose NMO in low-resource settings
A low-cost, mail-in dried-blood-spot test is being studied to diagnose neuromyelitis optica in people who live far from big labs or in low-income countries.
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Supercomputer models to understand how human motor signals reach muscles
A computer-based effort uses human motoneuron models to figure out the exact mix of inputs that control muscle activity.
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Negotiation training to help Alzheimer’s caregivers communicate with care teams
A program called NegotiAge helps families caring for people with Alzheimer’s disease learn better negotiation skills to talk with doctors, insurers, and other caregivers.
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Brain gene organization in development and neuron wiring
A study in mice looks at how large genome regions inside neuron nuclei help shape brain connections during development.
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Whisker system brain signals: making 3D models to understand how touch is coded
A project to build user-friendly 3D software that models how whisker movements in rodents are translated into neural signals in the trigeminal system, helping us understand tactile sensing.
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Understanding why some kids can’t understand what they read even when they can sound out words
A short project aims to learn why some children struggle with reading comprehension despite having normal decoding skills, with the goal of finding ways to help them.
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Mobile safety planning for at-risk young adults
A digital, text-based safety planning program for young adults (ages 18–24) to help prevent suicide and stay connected to support.
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Intracellular Vitamin D to Protect Islet Transplants from IBMIR
A tiny vitamin D–based therapy is being tested to protect transplanted islets in people with type 1 diabetes by reducing inflammation and blood clotting that can kill the graft.
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HIV Implementation Science Coordination Initiative
A national effort to speed up and spread through communities proven HIV interventions so people who are most affected can get better care and prevention.
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Melanoma vaccine built from tiny spherical nucleic acids
A new kind of cancer vaccine using tiny spherical nucleic acids to help the immune system fight advanced melanoma.
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Multiplex imaging of brain activity and plasticity with optimized sensors
A study to build and test red fluorescent sensors that let scientists see brain signals and molecular changes at the same time in living mice.
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Advanced imaging sensors to watch brain plasticity in living animals
Researchers are building highly sensitive red fluorescent sensors to visualize real-time brain signaling and structural changes in living mice.
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Liver Cirrhosis Network: Coordinating Data for Better Care
A national effort is coordinating data to improve care for people with advanced liver disease and its complications.
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A new online brain-scan-style tool to spot early psychosis risk
A new online-based set of tasks and a computer model aims to identify people at high risk for developing psychosis earlier and more accurately.
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Cortical roots of a noninvasive brain signal for speech processing
A study at Northwestern University aims to understand how the cortex shapes a noninvasive brain signal (FFR) used to assess speech processing in people.
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Food allergy outcomes by race/ethnicity from infancy through adolescence
This study follows children with food allergies over time to understand how race and ethnicity relate to allergy management, outcomes, and quality of life.
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NU-CoFAR Clinical Research Center: advancing food allergy care
A new NUCoFAR center at Northwestern will enroll children and adults with food allergies (and pregnant women/infants for prevention) to study how allergies develop, how severe reactions can be predicted, and how to improve access to care.
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Harnessing caregiver coaching in early intervention to help young children with developmental delays
This grant tests whether coaching caregivers can help children under 3 with developmental delays get high-quality, frequent early intervention in their home environment.
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VEGF-mimetic nanoparticles to help spinocerebellar ataxia type 1
A new, patient-friendly approach is being developed to deliver a VEGF-like therapy using tiny particles that could protect brain cells in spinocerebellar ataxia type 1.
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Understanding PACS1 Syndrome to help brain development
Researchers are studying how a specific PACS1 gene change affects brain development in people with neurodevelopmental differences, with the goal of guiding future therapies.
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Portable heart scans with AI could help aging adults living with HIV
A small NIH grant is testing an AI-augmented handheld heart ultrasound to detect early heart problems in older adults living with HIV in Tanzania.
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Spatial metabolism mapping in cancer cachexia tissues
Aims to map where and how metabolism changes in tissues affected by cancer cachexia using advanced imaging technology.
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West Africa Self-Sampling HPV Program for WLWHA
Aiming to help women living with HIV in West Africa screen for cervical cancer safely at home using self-sampling HPV tests and connect them to follow-up care.
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West Africa self-sampling HPV program for women living with HIV/AIDS
A U01 grant to test a self-sampling HPV screening approach for women living with HIV/AIDS in West Africa to help catch cervical cancer earlier.
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Reagentless sensors for continuous heart-failure biomarker monitoring
A wearable, self-generating sensor system aims to continuously track heart failure biomarkers in at-risk adults without any reagents.
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Active HCV diagnosis to help curb liver cancer in Africa
A project to develop and validate a rapid HCV test on the DASH platform to improve diagnosis and prevent liver cancer in sub-Saharan Africa, especially Nigeria and other LMIC settings.
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Active HCV diagnosis to prevent liver cancer in Africa with a new DASH test
A National Institute of Health-funded project aims to develop and validate a simpler HCV diagnostic test to help people in Sub-Saharan Africa get timely treatment and reduce liver cancer risk.
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Active HCV diagnosis to help prevent liver cancer in low-resource regions
A project to improve how doctors diagnose hepatitis C in sub-Saharan Africa, with a focus on Nigeria, to prevent liver cancer and save lives.
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Personalized hearing aid settings to help with your hearing
A study at Northwestern University will try customized hearing aid processing to see if people hear better when the device matches their abilities.
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Understanding how the cerebellum guides movement and learning
A research project at Northwestern University looks at how brain signals in the cerebellum help coordinate movement and adapt to new motor tasks in mice and zebrafish.
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HeartShare DeCODE-HF: A data hub to link omics, deep phenotyping, and EHRs for heart failure subtypes
A data-sharing center is being created to combine genetics and clinical data from many people with heart failure to help identify different subtypes and possible treatment targets.
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CHICAGO-HF: Next-Gen Omics and Deep Phenotyping to Understand Heart Failure
A nationwide effort to deeply profile people with a type of heart failure called HFpEF so doctors can tailor better treatments.
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Nutrition for Precision Health in the All of Us program
A large NIH grant aims to study how people respond to a DASH-style diet to personalize nutrition advice, using All of Us participants and real-time data.
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Dysregulated ovarian debris clearance driving aging and inflammation in the ovary
A study at Northwestern University looks at why the aging ovary accumulates waste and inflammation, and how this affects fertility and hormone function.
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Healthy Brain and Child Development: a large study tracking how early life experiences shape child brain growth
This project follows thousands of mothers and infants to map how genes, environments, and early experiences influence brain development over the first 10 years.
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Why some blood stem cells take over with age
Researchers are looking at whether infections and chronic inflammation help p53‑mutant blood stem cells expand and raise the risk of pre‑cancerous blood disorders in older adults.
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Mapping how proteins fold and misfold in natural and engineered proteins
The team is building a fast way to map hidden protein shapes to help people affected by protein-clumping diseases and those who use protein medicines.
Quick answers
How many clinical trials run by Northwestern University are recruiting right now?
147, as of November 12, 2026. 3 of them were first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 4 countries. The most sites are in United States (146 trials), Nigeria (1 trial), Thailand (1 trial), Ukraine (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 19, Early Phase 1: 8, Phase 4: 7, Phase 3: 5. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.