Magneto 150 vs MOSES 2.0 for HoLEP in Benign Prostatic Hyperplasia
Official title: MOSES 2.0 vs Quanta Magneto 150 Holmium Laser for Holmium Laser Enucleation of the prostate-a Randomized Controlled Trial
Run by Northwestern University · NCT07632742 · Data updated 2026-11-12
This trial tests whether the Magneto 150 holmium laser can shorten intraoperative bleeding time compared with MOSES 2.0 during HoLEP for enlarged prostate.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | Men only |
| Enrollment | 180 (estimated) |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | May 29, 2026 |
| Main results expected | June 2027 |
| Study ends | June 2028 |
| Registry record updated | October 15, 2026 |
| Trial ID | NCT07632742 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults with bothersome lower urinary tract symptoms due to enlarged prostate scheduled for HoLEP and able to complete online postoperative surveys.
✕Probably not a fit
Patients on anticoagulation therapy, those without internet access, or those unable to complete English-language surveys may not benefit from this approach.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This randomized trial compares two holmium laser technologies used during HoLEP for benign prostatic hyperplasia. Participants undergo HoLEP with either the Magneto 150 laser or the MOSES 2.0 laser, with the primary focus on intraoperative hemostasis time. The study also examines safety and feasibility, leveraging patient-reported postoperative surveys to assess recovery and outcomes. Northwestern University leads the study with Cook Group Incorporated as a collaborator, at a single site in Chicago, IL. Eligibility requires undergoing HoLEP, internet access for surveys, and English literacy, with exclusions for anticoagulation and decisional incapacity.
Why it matters
Potential benefit: If successful, the Magneto 150 may reduce bleeding during HoLEP and improve perioperative efficiency.
How similar studies have gone: Prior laser technologies with pulse-modulation have shown potential gains; this study tests a novel Magneto setting in a randomized design to confirm benefits.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Undergoing HoLEP for the treatment of bothersome lower urinary tract symptoms * Internet access and a device to complete postoperative questionnaires (smartphone, tablet, laptop or desktop computer) Exclusion Criteria: * Patients who lack decisional capacity * Patients unable to read/speak English * Patients who are on a blood thinner (anticoagulation medication) * Patients who do not have internet access to complete postoperative surveys
Where it's running
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Northwestern University
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Perry Xu, MD — Northwestern University
- Study coordinator: Alyssa McDonald, MPH
- Email: alyssa.mcdonald@northwestern.edu
- Phone: 312-695-8146
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.