Evaluating the effectiveness of robotic-assisted bronchoscopy for lung nodule biopsy and staging
Official title: The SEQUENCE Trial: Should Endobronchial Ultrasound QUeue bEfore or eNsuing to robotiC-assisted Bronchoscopy for pEripheral Pulmonary Nodule Biopsy?
Run by Northwestern University · NCT06676956 · Data updated 2026-11-12
This study is testing if using robotic-assisted bronchoscopy with ultrasound helps doctors better and faster diagnose lung nodules to improve treatment outcomes.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 320 (estimated) |
| Sponsor | Northwestern University Academic / other |
| Locations | 5 sites (Sacramento, California and 4 other locations) |
| Status | Recruiting |
| Started | November 10, 2024 |
| Main results expected | August 2027 |
| Study ends | December 2027 |
| Registry record updated | August 25, 2026 |
| Trial ID | NCT06676956 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with peripheral pulmonary nodules who are scheduled for robotic-assisted bronchoscopy.
✕Probably not a fit
Patients with enlarged or PET avid lymph nodes prior to the procedure may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This trial investigates the diagnostic yield of robotic-assisted bronchoscopy (RaB) when combined with endobronchial ultrasound (EBUS) for staging pulmonary nodules. The study aims to determine whether performing EBUS first or second during the same procedure affects the accuracy and efficiency of diagnosing lung nodules. By utilizing advanced imaging techniques like cone-beam CT (CBCT), the trial seeks to enhance the precision of needle placement during biopsies. The goal is to streamline the process from nodule discovery to treatment while maintaining high diagnostic yields.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate diagnoses and quicker treatment for patients with pulmonary nodules.
How similar studies have gone: While there are no randomized trials directly comparing RaB and CBCT with other methods, retrospective studies have shown promising diagnostic yields.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Peripheral Pulmonary Nodule undergoing a robotic-assisted bronchoscopy Exclusion Criteria: * lymph nodes that are enlarged or PET avid on CT prior to procedure
Where it's running
-
University of California, Davis
Sacramento, California, United States Recruiting -
Northwestern University
Chicago, Illinois, United States Recruiting -
Johns Hopkins University
Baltimore, Maryland, United States Recruiting -
University of Michigan
Ann Arbor, Michigan, United States Recruiting -
University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States Recruiting
Study contacts
- Study coordinator: Chris Kapp Assistant professor of medicine, MD
- Email: christopher.kapp@nm.org
- Phone: 312-695-3800
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.