Evaluating the effectiveness of robotic-assisted bronchoscopy for lung nodule biopsy and staging
The SEQUENCE Trial: Should Endobronchial Ultrasound QUeue bEfore or eNsuing to robotiC-assisted Bronchoscopy for pEripheral Pulmonary Nodule Biopsy? A Patient Randomized Control Trial Assessing the Effect of the Ordering of Robotic-assisted Bronchoscopy and Linear EBUS During the Same Anesthesia Event on Diagnostic Yield From Peripheral Pulmonary Nodule Biopsy
This study is testing if using robotic-assisted bronchoscopy with ultrasound helps doctors better and faster diagnose lung nodules to improve treatment outcomes.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 320 (estimated) |
| Ages | 18 Years and up |
| Sex | All |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Trial ID | NCT06676956 on ClinicalTrials.gov |
What this trial studies
This trial investigates the diagnostic yield of robotic-assisted bronchoscopy (RaB) when combined with endobronchial ultrasound (EBUS) for staging pulmonary nodules. The study aims to determine whether performing EBUS first or second during the same procedure affects the accuracy and efficiency of diagnosing lung nodules. By utilizing advanced imaging techniques like cone-beam CT (CBCT), the trial seeks to enhance the precision of needle placement during biopsies. The goal is to streamline the process from nodule discovery to treatment while maintaining high diagnostic yields.
Who should consider this trial
Good fit: Ideal candidates are patients with peripheral pulmonary nodules who are scheduled for robotic-assisted bronchoscopy.
Not a fit: Patients with enlarged or PET avid lymph nodes prior to the procedure may not benefit from this study.
Why it matters
Potential benefit: If successful, this approach could lead to more accurate diagnoses and quicker treatment for patients with pulmonary nodules.
How similar studies have performed: While there are no randomized trials directly comparing RaB and CBCT with other methods, retrospective studies have shown promising diagnostic yields.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Peripheral Pulmonary Nodule undergoing a robotic-assisted bronchoscopy Exclusion Criteria: * lymph nodes that are enlarged or PET avid on CT prior to procedure
Where this trial is running
Chicago, Illinois
- Northwestern University — Chicago, Illinois, United States (Recruiting)
Study contacts
- Study coordinator: Chris Kapp Assistant professor of medicine, MD
- Email: christopher.kapp@nm.org
- Phone: 312-695-3800
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.