Understanding how different parts of the human amygdala process smells
Official title: Characterization of Human Olfactory Amygdala Subregions
Run by Northwestern University · NCT04699799 · Data updated 2026-11-12
This study is trying to see how different parts of the brain help us process smells by testing various odors on people and looking at their brain activity.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 100 (estimated) |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | January 1, 2022 |
| Main results expected | April 1, 2027 |
| Study ends | April 1, 2027 |
| Registry record updated | May 12, 2026 |
| Trial ID | NCT04699799 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are adults over the age of 18 who are interested in participating in olfactory research.
✕Probably not a fit
Patients with olfactory dysfunction or those under 18 years of age may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This study aims to explore the specific subregions of the human amygdala that receive direct input from the olfactory bulb, which is crucial for processing smells. By presenting various odors to participants and recording their brain activity, researchers hope to uncover the distinct roles these amygdala subregions play in olfactory processing. The study addresses a gap in current knowledge, as most previous research has focused on rodent models or has not differentiated between amygdala subregions in humans. The findings could enhance our understanding of how the brain processes olfactory information and its implications for behavior.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of olfactory processing in humans, potentially informing treatments for conditions related to smell.
How similar studies have gone: While there have been successful studies on olfactory processing in rodents, this approach focusing on human amygdala subregions is relatively novel and less explored.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * older than 18 years of age Exclusion Criteria: \-
Where it's running
-
Northwestern human olfaction lab
Chicago, Illinois, United States Recruiting
Study contacts
- Study coordinator: Christina Zelano, PhD
- Email: c-zelano@northwestern.edu
- Phone: 312-503-4437
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.