Study on how lifestyle factors affect women's reproductive health before pregnancy
Official title: The PROMISE Study: PROspective Study of Mothers' and Infants' Social and Epidemiologic Determinants of Health
Run by Northwestern University · NCT05358483 · Data updated 2026-11-12
This study looks at how things like sleep, diet, and exercise can affect women's health and pregnancy outcomes before they become pregnant.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 44 Years |
| Sex | Women only |
| Enrollment | 1000 (estimated) |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | September 7, 2021 |
| Main results expected | December 2046 |
| Study ends | December 2046 |
| Registry record updated | June 16, 2026 |
| Trial ID | NCT05358483 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates for this study are women aged 18-44 who are actively seeking pregnancy and have not undergone prior IVF cycles.
✕Probably not a fit
Patients using donor oocytes or gestational carriers, or those unable to provide informed consent, may not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The PROMISE study aims to explore the impact of pre-conception lifestyle factors such as sleep, nutrition, and physical activity on reproductive outcomes for women and their children. By focusing on women aged 18-44 who are seeking pregnancy, the study seeks to gather data on social and epidemiologic determinants of health before conception. This observational study will utilize validated surveys to collect information on modifiable lifestyle factors, with the goal of identifying actionable interventions that could improve long-term health outcomes. The study will follow participants for up to 25 years, allowing for a comprehensive analysis of health trends over time.
Why it matters
Potential benefit: If successful, this study could lead to improved reproductive health outcomes for women and their children by identifying effective pre-conception interventions.
How similar studies have gone: While there is existing research on maternal and child health, this study's focus on pre-conception factors is relatively novel and has not been extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Women ages 18-44 seeking pregnancy at Northwestern Fertility and Reproductive Medicine (FRM) who agree to 1. Be followed for a period for up to 25 years 2. Share information regarding their child's health * No prior IVF cycles Exclusion Criteria: * Women using donor oocytes or gestational carriers * Inability or unwillingness to provide informed consent for any aspects of the study
Where it's running
-
Northwestern Medicine Fertility and Reproductive Medicine
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Emily Jungheim, MD, MCSI — Division Chief of Reproductive Endocrinology and Infertility
- Study coordinator: Emily Jungheim, MD, MSCI
- Email: Emily.Jungheim@nm.org
- Phone: 312-926-6643
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.