Jeeejaculatory-Sparing HoLEP for Uprating Ejaculation During Prostate Surgery
Official title: Ejaculatory-sparing Holmium Laser Enucleation of the Prostate (HoLEP) vs Standard HoLEP: a Randomized Controlled Trial
Run by Northwestern University · NCT07631286 · Data updated 2026-11-12
A new ejaculatory-sparing HoLEP procedure is being tested to see if it can preserve ejaculation while treating enlarged prostate with urinary symptoms.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | Men only |
| Enrollment | 48 (estimated) |
| Sponsor | Northwestern University Academic / other |
| Locations | 1 site (Chicago, Illinois) |
| Status | Recruiting |
| Started | June 15, 2026 |
| Main results expected | May 2027 |
| Study ends | May 2028 |
| Registry record updated | August 20, 2026 |
| Trial ID | NCT07631286 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Men with enlarged prostate and bothersome urinary symptoms who are sexually active and currently have antegrade ejaculation, and who are candidates for HoLEP.
✕Probably not a fit
Patients who are not sexually active, have pre-existing retrograde ejaculation, or have conditions or circumstances that affect ejaculation or reading English may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This interventional study compares a novel ejaculatory-sparing HoLEP technique to standard HoLEP in men undergoing surgery for benign prostatic hyperplasia with bothersome urinary symptoms. The trial focuses on preserving antegrade ejaculation while achieving effective urinary outcomes. Participants are sexually active men without pre-existing retrograde ejaculation who require HoLEP and can read/speak English. The primary goal is to determine the efficacy of ES-HoLEP in maintaining ejaculation, with secondary assessment of urinary function post-surgery. Northwestern University leads the study at its Chicago site, with no listed collaborators.
Why it matters
Potential benefit: If successful, ES-HoLEP could help men preserve ejaculation after prostate surgery while still relieving urinary symptoms.
How similar studies have gone: Limited prior data on ejaculatory-sparing prostate procedures exist; this study explores a relatively novel approach in a well-defined surgical population.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: \- Patients who are sexually active with antegrade ejaculation who are undergoing HoLEP for the treatment of bothersome lower urinary tract symptoms. Exclusion Criteria: * Patients with pre-existing retrograde ejaculation * Patients who are not sexually active * Patients with indwelling urinary catheter prior to surgery, neurological disease, or history of prior prostatic/urethral surgery that may impact ejaculation * Patients who lack decisional capacity * Patients unable to read/speak English
Where it's running
-
Northwestern University
Chicago, Illinois, United States Recruiting
Study contacts
- Principal investigator: Amy E Krambeck, MD — Northwestern University
- Study coordinator: Alyssa McDonald, MPH
- Email: alyssa.mcdonald@northwestern.edu
- Phone: 312-695-8146
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.