CHICAGO-HF: Next-Gen Omics and Deep Phenotyping to Understand Heart Failure
Official title: CHIcago Center for Accelerating nextGen Omics, deep phenotyping, and data science in Heart Failure (CHICAGO-HF)
Funded at Northwestern University · NIH-11529021 · Data updated 2026-11-12
A nationwide effort to deeply profile people with a type of heart failure called HFpEF so doctors can tailor better treatments.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Northwestern University NIH-funded |
| Lab location | 1 site (Chicago, United States) |
| Project start | September 10, 2021 |
| Project end | January 31, 2028 |
| Funding year | 2026 |
| Award (this year) | $424,338 |
| NIH project number | 3U01HL160279-05S1 |
| Project ID | NIH-11529021 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults with heart failure, particularly HFpEF, who can undergo advanced imaging and tissue sampling as part of a comprehensive phenotyping effort.
✕Less likely to help
People who cannot undergo imaging or biopsy procedures, or whose condition makes participation unsafe, may not benefit.
What this research studies
This project creates a multicenter program to map the biology of HFpEF using cutting-edge imaging, tissue samples, and data science. It will gather detailed heart and body-wide information from participants to identify distinct HFpEF subtypes. The goal is to use these insights to guide precision medicine approaches and future targeted therapies. Participants will contribute MRI data, possible biopsy samples, and health information to a large, collaborative database.
Why it matters
Potential benefit: If successful, patients with HFpEF could receive more personalized care and more effective treatment strategies.
How similar studies have gone: Previous large-scale phenotyping efforts have started to reveal HFpEF subtypes, with ongoing work showing promise for precision approaches.
Where this research is happening
-
Northwestern University
Chicago, United States Active
Researchers
- Principal investigator: Khan, Sadiya Sana — Northwestern University
- Study coordinator: Khan, Sadiya Sana
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.