Sponsor or institution
Clinical trials and research at M.D. Anderson Cancer Center
As of November 12, 2026, Find a Trial lists 509 clinical trials run by M.D. Anderson Cancer Center that are recruiting, at sites in 18 countries (most in United States (509), Canada (2), Colombia (1)). 1 was first registered in the last 30 days. By phase: Phase 2 (156), Phase 1 (75), Phase 1/2 (49), Early Phase 1 (7). Every study is explained in plain English. Data from ClinicalTrials.gov and NIH RePORTER, updated November 12, 2026.
- 509Clinical trials
- 1New in 30 days
- 18Countries
Newest trials
All recruiting trials (newest 150 of 509)
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Preventing heart problems in overweight/obese young sarcoma survivors with tirzepatide
This feasibility study tests whether tirzepatide can be safely given to overweight or obese young adults (18–39) who have completed doxorubicin for soft tissue or bone sarcoma to see if it’s feasible to use in the first year after therapy.
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Predicting lymphedema risk in inflammatory breast cancer patients using preoperative body impedance analysis
This study tests whether a preoperative bioimpedance test can help identify IBC patients who are at risk for developing lymphedema.
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Precision genomic testing to guide first-line LBCL treatment readiness
Doctors will see if a tumor genomic test can help tailor first-line treatment for adults with LBCL by the start of the second cycle of standard therapy.
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Using Apple Vision Pro in image-guided procedures
This study tests whether the Apple Vision Pro can be used during CT-guided biopsy procedures to help with imaging and guidance.
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Geniculate Artery Embolization for Knee Osteoarthritis in Cancer Patients
This study tests whether blocking knee blood vessels with a standard care procedure can help reduce pain and improve function in people with knee osteoarthritis who also have cancer.
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Urothelial Carcinoma Biospecimen Collection and Data Study
This project tests collecting and storing tissue, blood, and imaging data from adults with urothelial carcinoma to support translational research.
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Chatbot support for informed consent in research
A chatbot named CoCo is tested to see if it can help patients understand and feel satisfied with the consent process for research studies.
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Bone Marrow Imaging and Outcomes Across Blood C cancers and Related Conditions
This observational study follows patients undergoing bone marrow imaging to see how imaging features relate to treatments and outcomes over time.
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Gemcitabine, Docetaxel, Melphalan, and Carboplatin with a Second Transplant in Young Patients with Relapsed Germ Cell Tumors
This study tests whether a tandem autologous stem cell transplant with GemDMC, followed by CE, can help children and teens with relapsed or refractory germ cell tumors.
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Omitting brain metastasis radiation after tumor removal when CNS-active therapy is used
This pilot study tests whether patients with resected brain metastases from melanoma or NSCLC can skip post-operative brain radiation while receiving CNS-active systemic therapy.
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Ivonescimab in advanced cutaneous angiosarcoma: a first look
This Phase 2 pilot tests ivonescimab in adults with advanced or metastatic cutaneous angiosarcoma who have already had taxane-based chemotherapy.
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G207 with 5 Gy Radiation for pediatric high-grade glioma
This study tests whether injecting G207 into a brain tumor plus a single 5 Gy radiation dose is safe and could help extend survival for children with recurrent or progressive high-grade gliomas.
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Ropeginterferon Alfa-2b added to azacitidine in TP53-mutant MDS/AML
This study tests whether adding ropeginterferon alfa-2b to azacitidine helps people with TP53-mutant MDS/AML, by finding an effective dose and looking for tumor response.
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REC-617 treatment in RB1-negative leiomyosarcoma for adults who have had prior therapy
This study tests REC-617 to see if it can help control RB1-negative leiomyosarcoma in adults who have already received prior systemic treatment.
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Increase representation of minority patients in prostate cancer trials at LBJ Hospital
This project tests a multi-pronged approach, including a culturally tailored video, provider education, and nurse navigation, to see if it increases enrollment of minority patients on prostate cancer trials at LBJ Hospital.
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Navlimetostat with Pumitamig in MTAP-Deficient Advanced NSCLC
This study tests if navlimetostat plus pumitamig can be given safely to adults with MTAP-deficient advanced non-small cell lung cancer to see if the combo works against their disease.
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Engineered NK Cells with dual CARs for recurrent glioblastoma
This study tests whether delivering specially engineered natural killer (NK) cells to glioblastoma patients is safe and helps fight the tumor, using three different administration routes to find the best approach.
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Baseline anxiety patterns in children receiving radiation therapy
This project will track how anxiety changes during radiation treatment in children ages 2–12 to see if specific visits or conditions make anxiety worse.
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Phase 2 test of mosunetuzumab for CLL patients with detectable MRD
This study tests whether adding mosunetuzumab to ongoing BTKi therapy can eliminate detectable minimal residual disease in adults with chronic lymphocytic leukemia who still have MRD after BTKi treatment.
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LNK001 CAR T therapy in advanced clear cell kidney cancer
This study tests a CAR T-cell therapy called LNK001 to see if it can help people with advanced clear cell renal cell carcinoma after other treatments.
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Nivolumab plus AVD for newly diagnosed early-stage non-bulky classical Hodgkin lymphoma in young patients
This study tests whether nivolumab added to AVD can help children, teens, and young adults with newly diagnosed early-stage non-bulky Hodgkin lymphoma.
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Peer support community for people with neuroendocrine cervical cancer
This project will test whether joining a technology-based peer support community helps adults with neuroendocrine cervical cancer feel less isolated and improve emotional well-being and illness perception.
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Zanzalintinib for Recurrent or Metastatic Olfactory Neuroblastoma
This study tests whether zanzalintinib can help control recurrent or metastatic olfactory neuroblastoma and whether it is safe.
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A combination therapy for teens and young adults with relapsed or refractory T-ALL/T-LBL
This phase 1 study tests a four-drug regimen (venetoclax, dexamethasone, bortezomib, and daratumumab) in adolescents and young adults whose T-cell ALL or T-cell lymphoblastic lymphoma has come back or not responded.
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Intermittent fasting in people at high risk for pancreatic cancer
This study tests whether intermittent fasting is tolerable and feasible for people at high risk of pancreatic cancer and whether it changes biological markers like metabolism, inflammation, microbiome, and imaging signals.
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TROP2 CAR/IL-15 TGFBR2 KO NK cells for stomach cancer that has spread to the peritoneum
Researchers are testing a special cell therapy delivered into the abdomen to see if it is safe and can help people with stomach cancer that has spread to the lining of the abdomen.
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BTK degrader plus BCL-2 inhibitor in untreated CLL/SLL
This phase 2 study tests whether the BTK degrader BGB-16673 together with sonrotoclax can help people with newly diagnosed CLL/SLL.
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Azacitidine with APG1252 in high-risk AML (Phase 1b/2)
This study tests whether adding APG1252 to azacitidine is safe and helps some patients with high-risk AML feel better or respond to treatment.
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SAR445877 with FOLFOX6 and bevacizumab as first-line treatment for MSS metastatic colorectal cancer
This study tests whether giving SAR445877 together with FOLFOX6 and bevacizumab is safe and tolerable as a first-line treatment for adults with MSS metastatic colorectal cancer.
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Radiofrequency ablation treatment for recurrent parathyroid cancer in the neck
This trial will try ultrasound-guided radiofrequency ablation in adults with recurrent parathyroid carcinoma and uncontrolled high blood calcium to see if it lowers their calcium and parathyroid hormone (PTH) levels.
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Intracranial Venous Blood Sampling for Brain Tumor Liquid Biopsy
This study tests whether taking blood from veins inside the brain can safely and reliably reveal molecular information about high-grade gliomas using a liquid biopsy.
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Pressure-enabled delivery for liver tumors using TriNav: see how it changes tumor-to-normal liver contrast
This trial tests whether the TriNav infusion system changes how a liver tumor looks on CT compared with normal liver tissue during Y90 treatment in adults with unresectable liver tumors.
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CAR27/IL-15 NK cells with TGFBR2 KO for relapsed or refractory lymphoid cancers
This phase 1 basket trial tests a modified natural killer cell therapy (CAR27/IL‑15 NK cells with TGFBR2 knocked out) in adults with relapsed or refractory B-cell lymphomas, Hodgkin lymphoma, T-cell lymphomas, or B-ALL after lymphodepletion.
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Pazopanib added to a multi-drug regimen for kids and young adults with recurrent soft tissue sarcomas
This study tests whether adding pazopanib to a regimen of trabectedin, ipilimumab, and nivolumab is safe and possibly beneficial for children and young adults with recurrent soft tissue sarcomas.
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DNX-2401 for melanoma that has spread to the brain or elsewhere
This study tests different dose levels and injection schedules of DNX-2401 to see if it can be safely given to adults with metastatic melanoma that has both brain and/or other sites.
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Sacituzumab Tirumotecan in SMARCB1-Deficient Renal Medullary Carcinoma
Aims to see if sacituzumab tirumotecan can help control advanced SMARCB1-deficient renal medullary carcinoma in patients whose disease has progressed after prior therapy.
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Optimizing gadopiclenol MRI to detect early leptomeningeal disease
This study tests whether using gadopiclenol during brain MRI can improve early detection of leptomeningeal disease in adults with solid cancers.
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Lorlatinib with local consolidation therapy for ALK-positive advanced non-small cell lung cancer
This trial will test whether adding local consolidation treatments to lorlatinib helps people with ALK-positive advanced non-small cell lung cancer stay progression-free longer.
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TROP2‑targeted CAR‑NK cells given into the abdomen and vein for colorectal cancer spread to the peritoneum
We will test whether giving TROP2‑directed CAR‑NK cells both into the abdominal cavity and into a vein, together with cetuximab, is safe and what dose is best for adults with colorectal cancer that has spread to the peritoneum.
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Adjunct Therapy De-escalation in Early HER2+ and TNBC After Neoadjuvant Response
This phase 2 trial tests stopping certain post-surgery immunotherapy and targeted therapies early in people with early HER2+ or triple-negative breast cancer who have no detectable cancer DNA after neoadjuvant treatment and surgery.
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HC-7366 plus nivolumab with or without ipilimumab for advanced clear-cell kidney cancer (SHARK)
This trial tests whether adding HC-7366 to nivolumab, with or without ipilimumab, can help control advanced clear-cell kidney cancer.
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JV-394 CAR T therapy for relapsed or refractory CD94-positive T/NK-cell cancers
This trial will test whether using a patient’s own modified immune cells (JV-394 CAR T) is safe and find the best dose for adults with relapsed or refractory CD94-positive T/NK-cell lymphoma.
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Separating heart side effects from cancer benefit of immunotherapy
This project will try to find which adults starting immune checkpoint inhibitors are likely to have heart problems versus cancer benefit by testing blood markers like metabolomics, CHIP, and epigenetic aging.
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Low-dose radiation to boost elranatamab for relapsed/refractory multiple myeloma with extramedullary or paramedullary disease
We will test whether low-dose radiation given before elranatamab helps people with relapsed or refractory multiple myeloma that has grown outside the bone or into surrounding tissue respond better to treatment.
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Izalontamab Brengitecan plus Adagrasib in KRAS G12C NSCLC
This study tests whether the drug combo iza-bren and adagrasib can help adults with advanced KRAS G12C-mutant non-small cell lung cancer that has progressed after KRAS G12C inhibitors fail.
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Shared decision tool to help choose the levonorgestrel IUD for preventing endometrial cancer
This project will try a web-based decision tool in English and Spanish to help women at risk of endometrial cancer and their healthcare providers consider using a levonorgestrel-releasing IUD for prevention.
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Lung cancer screening decision aid adapted for patients at a safety-net health system
This project will test whether English and Spanish video and written decision aids help Harris Health patients who are current or recent smokers make clearer choices about lung cancer screening.
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BMS-986504 with olaparib for advanced solid tumors that have MTAP loss
This study tests whether combining BMS-986504 with olaparib is safe and has anti-tumor activity in adults with advanced solid tumors that have MTAP loss.
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Decision support to help germline genetic testing for men with prostate cancer
A tool is being tested to help men with prostate cancer decide about germline genetic testing and see if it increases testing completion.
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Reducing pain and emotional distress during gynecologic brachytherapy applicator removal
This project will see if women who receive gynecologic brachytherapy develop PTSD and whether pain, anxiety, or use of propofol during applicator removal are linked to it.
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4‑FN PET/CT scans to detect and track chronic graft‑versus‑host disease in joints
This pilot will test whether a PET/CT scan using the tracer 4‑[18F]Fluoro‑1‑naphthol (4FN) is safe and can detect or predict chronic graft‑versus‑host disease manifestations in adults.
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ASCEND-CRC: Testing personalized drug combinations for metastatic colorectal cancer
We’re testing whether giving targeted drug combinations based on each patient’s tumor features can help control metastatic colorectal cancer.
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Avutometinib, Defactinib, and Everolimus for RAS-pathway Mutant Endometrial Cancer
This study tests a three-drug combination to see if it’s safe and how it works in patients with recurrent endometrial cancer that has RAS pathway mutations.
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Lisocabtagene maraleucel to prevent recurrence of large B‑cell lymphoma after first-line therapy
This trial tests whether a CAR T-cell treatment called liso-cel can prevent return of large B‑cell lymphoma in adults who are in complete remission after first-line chemoimmunotherapy but still have detectable lymphoma DNA.
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Combination therapy with ruxolitinib, cladribine, and venetoclax in relapsed/refractory T-cell prolymphocytic leukemia
This study tests whether a three-drug combo can control relapsed or refractory T-PLL in adults.
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Computer-assisted vacuum thrombectomy for intermediate-risk pulmonary embolism in cancer patients
This study will try computer-assisted vacuum thrombectomy in adults with current or prior cancer and intermediate-risk pulmonary embolism to see if it is safe and improves quality of life.
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Handheld mass spectrometry to tell MPNST, neurofibroma, and normal nerve tissue during surgery
This study will test whether a handheld mass spectrometry device can quickly tell malignant peripheral nerve sheath tumors (MPNST) from neurofibromas and normal nerve tissue during surgery for patients having tumor removal.
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Zanzalintinib plus pembrolizumab for select advanced soft-tissue sarcomas
This trial will test whether combining zanzalintinib with pembrolizumab can help control certain advanced or metastatic soft-tissue sarcomas in adults.
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BMS-986504 plus chemotherapy for MTAP-deleted pancreatic cancer
This trial tests whether adding BMS-986504 to standard chemotherapy (and surgery when appropriate) can help control MTAP-deleted pancreatic cancer in adults.
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NK cell therapy with epcoritamab and tafasitamab for relapsed or treatment‑resistant B‑cell lymphoma
This trial will try whether adding donor-derived ONC-PluReceptor NK cells to the antibodies epcoritamab and tafasitamab helps control relapsed or refractory CD19/CD20-positive B‑cell non‑Hodgkin lymphoma.
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Bringing DIGEST™ swallow-grading into cancer clinics
This project tests two ways of training clinics so they can use the DIGEST™ method to grade swallowing problems in cancer patients having Modified Barium Swallow tests.
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Dasatinib plus ropeginterferon for newly diagnosed chronic myeloid leukemia in chronic phase
This study tests whether the drug combination dasatinib and ropeginterferon can help control chronic myeloid leukemia in adults with newly diagnosed disease.
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BTKi‑rituximab induction followed by glofitamab consolidation for high‑risk newly diagnosed mantle cell lymphoma
This will test whether giving glofitamab after initial BTKi plus rituximab helps control high‑risk, newly diagnosed mantle cell lymphoma.
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Chaplain-clinician PEACE spiritual care for people with advanced cancer
This pilot will try a chaplain-clinician spiritual care program (PEACE) to see if it is feasible, acceptable, and can change how people with advanced cancer let their religious beliefs influence medical decisions.
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Ivonescimab for metastatic endocrine-refractory invasive lobular carcinoma (HR+ HER2− or triple-negative)
This trial will test whether the experimental antibody ivonescimab can control tumor growth in adults with metastatic invasive lobular breast cancer that is endocrine-refractory and either HR-positive/HER2-negative or triple-negative.
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Nano-pulsed Field Ablation for Benign Thyroid Nodules
This study tests whether nsPFA treatment for benign thyroid nodules helps reduce nodule size and improve symptoms in adults receiving standard care.
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NBTXR3 with radiation for locally advanced non-small cell lung cancer
This study will test whether adding NBTXR3 to radiation helps people with stage I–III non-small cell lung cancer who cannot have chemotherapy or surgery.
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Young-onset lung cancer registry and dedicated care program impact on patient experience
This project will see if enrolling adults under 50 with non-small cell lung cancer in a dedicated care program and peer support networks improves their satisfaction, quality of life, and related outcomes.
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Collection of extra lung samples during clinical pulmonary procedures
This project will collect extra samples from lung procedures—like bronchoalveolar lavage, pleural fluid, and blood—from adult patients at MD Anderson to build a biobank for research into pulmonary problems and treatment-related lung toxicity.
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Nanosecond pulsed field ablation for small papillary thyroid cancer
This will test whether ultrasound-guided nanosecond pulsed field ablation can shrink or remove small (≤1.5 cm) papillary thyroid cancers in patients without spread.
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Aerobic exercise during immune checkpoint inhibitor therapy for early-stage triple-negative breast cancer
This study will test whether a supervised aerobic exercise program helps people with early-stage triple-negative breast cancer who are receiving immune checkpoint inhibitor therapy before surgery.
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Financial burden after surgery for bone and soft tissue sarcoma
This project will see how much financial stress people who have surgery for bone or soft tissue sarcoma face and how that stress affects their quality of life.
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Zanzalintinib for advanced or metastatic bone sarcomas (ZAMBONE)
This study will see if zanzalintinib can slow disease progression in adults with advanced or metastatic bone sarcomas.
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Bone metastasis in clear cell kidney cancer: cabozantinib plus nivolumab feasibility and bone microenvironment study
This study tests whether cabozantinib with nivolumab can be given safely to people with clear cell renal cell carcinoma that has spread to bone and helps us see how bone immune cells respond.
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Neoadjuvant belzutifan, pembrolizumab, or both for clear cell kidney cancer
We will see if giving belzutifan alone, pembrolizumab alone, or both before kidney surgery helps shrink locally advanced clear cell kidney cancer.
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RISE‑YA tele‑exercise to reduce fatigue in young adult brain tumor survivors
This project will test whether a supervised tele‑exercise program called RISE‑YA helps reduce cancer‑related fatigue in young adults who survived brain tumors.
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Group-based Comprehensive Lifestyle Program for Women With Metastatic Breast Cancer
A lifestyle program is tried to see if women with stable HR+/HER2- metastatic breast cancer can take part and stay in an 8-week online or mixed-format intervention.
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Personalized Lu-177 PSMA (Pluvicto) dosing for people with reduced kidney or bone marrow function
This trial will try personalized dosing and imaging to see how much Pluvicto (Lu-177 PSMA) radiation reaches tumors and organs in people with prostate cancer who have reduced kidney or bone marrow function.
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Family-centered lifestyle program for Black prostate cancer survivors and their caregivers
This trial tests whether a family-centered lifestyle program helps Black prostate cancer survivors and their caregivers increase physical activity and improve diet, physical functioning, quality of life, and family health climate compared with survivor-only and control groups.
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Puxitatug Samrotecan (P‑Sam) for advanced, recurrent, or metastatic aggressive ACC‑I
This test sees if Puxitatug Samrotecan (P‑Sam) can shrink tumors or slow disease in adults with aggressive, recurrent, or metastatic ACC‑I, especially tumors with NOTCH mutations or low p63 expression.
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Virtual meaning-centered group therapy for adults with a history of cancer
This program will test whether a virtual meaning-centered group therapy helps adults with a history of cancer reduce anxiety and depression and improve quality of life and sense of meaning.
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Culturally adapted Spanish educational materials for Latino/a people with medullary thyroid cancer
This project will co-develop and test Spanish-language educational materials to help Latino/a adults with medullary thyroid cancer and their caregivers understand the disease and treatment options.
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Radiofrequency ablation for benign or indeterminate thyroid nodules and low‑risk papillary thyroid cancer
This project sees if radiofrequency ablation shrinks benign or indeterminate thyroid nodules and controls low‑risk papillary thyroid cancer in adults, and how the treatment affects patients' quality of life.
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Phase 2 testing of SAR445877, an immune‑modulating treatment for NSCLC that progressed after immunotherapy
This will try the drug SAR445877 to see if it can control advanced non‑small cell lung cancer in people whose tumors progressed after prior immune checkpoint inhibitor therapy.
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Axatilimab plus ruxolitinib for people with myelofibrosis or CMML
This trial tests whether adding axatilimab, an antibody that targets CSF1R, to ruxolitinib can help control disease and symptoms in adults with myelofibrosis or chronic myelomonocytic leukemia (CMML).
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How whole versus crushed belumosudil tablets behave in people with chronic GVHD
This will test whether taking belumosudil as whole tablets or crushed tablets suspended in water changes how the drug is absorbed in adults with chronic graft-versus-host disease.
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Using 18F-FSPG PET and ctDNA to guide Y90 treatment for hepatocellular carcinoma
This will test whether a special PET scan (18F-FSPG) plus blood ctDNA can predict and detect response to Y90 radioembolization in people with hepatocellular carcinoma.
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Focused Acceptance and Commitment Therapy (FACT) for people with advanced cancer
This program will try a short therapy called Focused Acceptance and Commitment Therapy (FACT) to see if it reduces worries about dying in people with advanced cancer.
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CAR-TROP2/IL-15 engineered cord-blood NK cell therapy with or without radiation for advanced head and neck cancer
This trial tests whether specially engineered cord-blood natural killer (NK) cells that target TROP2, make IL-15, and resist TGF-β, given with or without short-course radiation, are safe and possibly helpful for people with advanced or unresectable TROP2-positive head and neck cancer.
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Patient views on physician compassion, communication, and professionalism when EHR is used during visits
This study tests how patients perceive a physician's compassion, communication, and professionalism when an EHR is used during a visit, compared to a traditional visit without EHR.
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Intratumoral M032 (IL-12-expressing engineered HSV-1) for newly diagnosed diffuse midline glioma after radiation
This will test whether injecting M032, a modified herpes virus that produces IL-12, directly into the tumor is safe and how it affects children and adults with newly diagnosed diffuse midline glioma after they finish radiation.
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Shorter regional nodal radiation after lumpectomy or mastectomy for node-positive and high-risk node-negative invasive breast cancer
This trial tests whether shorter courses of regional nodal radiation after lumpectomy or mastectomy work as well and cause similar side effects for adults with node-positive or high-risk node-negative invasive breast cancer.
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Phase II decentralized adjuvant doxorubicin plus trabectedin for uterine leiomyosarcoma
This trial will try whether six cycles of doxorubicin plus trabectedin after surgery can prolong the time patients with stage 1b or 2 uterine leiomyosarcoma remain cancer-free.
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Allogeneic TGFBR2‑knockout CD70 CAR NK cell therapy for refractory clear cell renal cell carcinoma
This will test donor-derived TGFBR2‑knockout CD70 CAR NK cells given after lymphodepleting chemotherapy in adults with metastatic or unresectable clear cell renal cell carcinoma who progressed after immune checkpoint inhibitors and tyrosine kinase inhibitors.
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Regorafenib and lorigerlimab once radiographic MRD after colorectal cancer therapy
This study tests whether the drug combo regorafenib plus lorigerlimab can clear ctDNA-detected residual cancer after standard colorectal cancer therapy in high-risk patients.
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Obecabtagene autoleucel consolidation for newly diagnosed high-risk B-cell acute lymphoblastic leukemia
This trial will test whether a single infusion of the CAR‑T therapy obecabtagene autoleucel can help keep adults with newly diagnosed high‑risk B‑cell ALL in remission when given after initial chemotherapy.
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Surgery or LITT followed by a second focused radiosurgery versus close monitoring for recurrent brain metastases
This trial tests whether giving a second course of stereotactic radiosurgery after surgery or LITT helps people with recurrent brain metastases keep the tumor from coming back compared with close monitoring.
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Neoadjuvant atezolizumab and doxorubicin with preoperative radiation and adjuvant atezolizumab for high‑risk resectable limb and trunk soft tissue sarcoma
This will test whether adding the immunotherapy atezolizumab to doxorubicin chemotherapy before surgery, with radiation before surgery and more atezolizumab after surgery, can delay relapse in adults with high‑risk, resectable soft tissue sarcoma of the arms, legs, or trunk.
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Olutasidenib combined with targeted agents for relapsed IDH1‑mutated myeloid cancers with activated signaling mutations
This trial tests whether adding olutasidenib to targeted drugs or low‑intensity chemotherapy helps adults with relapsed or refractory IDH1‑mutated myeloid malignancies that also have an activated signaling mutation.
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Belzutifan vs active surveillance for indolent metastatic clear cell RCC
This study tests whether belzutifan can help control disease in adults with metastatic clear cell RCC who are candidates for active surveillance and have not had prior systemic therapy.
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Naxitamab plus sacituzumab govitecan for metastatic triple-negative breast cancer
This trial will test whether combining naxitamab with sacituzumab govitecan helps adults with metastatic triple-negative breast cancer.
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Website to teach people how to prevent liver cancer
This project will test a website that teaches adults at risk about liver cancer prevention and lets them get a personal risk summary.
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TA-DA: a patient decision tool to help with treatment choices after second-line therapy
This project will test a patient decision aid (TA-DA) to help adults with advanced cancer who have already received at least two lines of palliative systemic therapy talk with their clinicians about third-line or later treatment options.
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Personalized brain treatments for smokers using rTMS
This study is testing if personalized brain treatments using rTMS can help smokers reduce their nicotine cravings by looking at how their brains respond to emotions.
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Preventing lymphedema through immediate lymphatic reconstruction during surgery
This study is testing if a new surgery technique called immediate lymphatic reconstruction can help prevent lymphedema in patients with invasive breast cancer after they have lymph nodes removed.
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Compare two post-transplant drug combinations to prevent graft-versus-host disease
This phase 2 trial will test whether giving ruxolitinib instead of mycophenolate mofetil, together with cyclophosphamide and sirolimus after a stem cell transplant, better prevents graft-versus-host disease in older adults with AML or related blood cancers.
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Time-limited combination of pirtobrutinib, venetoclax and obinutuzumab for relapsed CLL/SLL
This trial will test whether a time-limited combination of pirtobrutinib, venetoclax, and obinutuzumab can control relapsed CLL/SLL in adults who have had prior therapy.
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Registry for patients with inflammatory breast cancer and MRD testing
This study is looking at patients with inflammatory breast cancer to see how often they test positive for minimal residual disease before surgery and how this affects their treatment and quality of life.
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Ivonescimab (anti-PD-1/VEGF bispecific) for previously treated metastatic colorectal cancer
This trial will test whether ivonescimab can help control metastatic colorectal cancer in adults whose disease has progressed after prior treatments.
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Zanzalintinib before surgery for advanced thyroid cancer
This will try zanzalintinib before surgery in adults with advanced or locally invasive thyroid cancers to shrink tumors and make surgery safer and less complex.
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Ivonescimab for previously treated advanced clear cell kidney cancer
This tests whether ivonescimab can shrink or control advanced clear cell kidney cancer in people whose disease progressed after at least one prior systemic treatment.
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CAR.70 and IL-15 modified cord blood NK cell therapy with TGFBR2 knockout plus chemotherapy for relapsed or refractory myeloid cancers
This will test a one-time infusion of genetically modified cord blood NK cells given after lymphodepleting chemotherapy to see if it helps adults with relapsed or refractory AML, MDS, or CMML.
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Chronic Loose Stools After Right-Sided Colectomy: How Bile Acids and Gut Bacteria Might Link to Symptoms
This study tests whether bile acid metabolism and small intestinal bacteria relate to chronic loose stools in patients after right-sided colectomy or total colectomy.
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Yoga app for patients receiving chest radiation and their family caregivers
This test tries a mobile app that delivers an unsupervised yoga program for people getting thoracic radiation and their family caregivers to see if it is usable and acceptable.
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MySnackTracker snack-only tracking versus full food tracking
This tests whether a simplified snack-only app (MySnackTracker) helps adults with BMI 28–40 stick with and enjoy diet tracking more than traditional full food logging.
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Reversing radiotherapy-related fibrosis and lymphedema in head and neck cancer survivors
This trial will test whether adding one of several drugs (pravastatin, pentoxifylline, ketoprofen, or pirfenidone) to standard care can prevent or reduce radiation-related fibrosis and lymphedema in people treated for head and neck cancer.
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Hyperpolarized xenon-129 MRI to monitor radiation response and lung toxicity in lung cancer
This trial will try inhaled hyperpolarized xenon-129 MRI scans to see if they can detect and predict radiation-related lung side effects in adults receiving radiation for lung cancer.
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Physical activity program for cancer survivors in Acres Homes
This study is testing a special exercise program for cancer survivors in Acres Homes to see if it helps them feel stronger and improve their quality of life.
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NovoTTF-200M and NovoTTF-200A devices to treat refractory spinal metastasis
This Phase I effort will test whether tumor‑treating fields delivered by the NovoTTF-200M or NovoTTF-200A devices are safe in adults with spinal metastases that have stopped responding to radiation, given alone or with standard systemic therapy.
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Radiation instead of hormone therapy after lumpectomy for older people with early ER+ breast cancer
This trial tests whether giving radiotherapy alone after lumpectomy—while skipping endocrine (hormone) therapy—works for people aged 60 and older with early, low-risk ER+ breast cancer.
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Immediate Lymphatic Repair at Lymph Node Surgery for Melanoma Patients
This study tests whether doing a lymphovenous bypass during lymph node removal for melanoma can help prevent lymphedema and improve recovery.
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Black Breast Cancer Survivors' Support and Wellness Course (BBCSI)
This project will test whether a community-based, peer-led BBCSI course can improve quality of life for Black women with stage 0–III breast cancer who are within four years of diagnosis.
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Mucormycosis Clinical Core for the MUCOR-ADVANCE P01 Project
This study collects and stores blood, tissue, BAL fluid, and related data from adults with cancer who have or are at risk for mucormycosis or other fungal infections to help understand the disease.
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Precision-MRD: biomarker-guided targeted treatment for colorectal cancer with minimal residual disease
This study will see if standard biomarker-directed cancer drugs change ctDNA levels in adults with colorectal cancer who have minimal residual disease.
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Evaluating stress levels in surgeons and musicians using various assessments
This study is trying to see how stress affects surgeons and musicians by measuring their anxiety and hormone levels before and after they perform their jobs.
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Understanding patient experiences with lung cancer screening
This study is trying to understand what makes it hard for people to get lung cancer screenings and how their experiences with scheduling these screenings can be improved.
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Systemic therapy with or without targeted liver radiation for advanced intrahepatic cholangiocarcinoma
This trial tests whether adding liver-directed radiation to standard chemotherapy plus durvalumab helps people with advanced intrahepatic cholangiocarcinoma live longer.
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DeepDOF imaging for cervical tissue at point-of-care
This study tests a new DeepDOF digital microscope to see if its cervical biopsy and LEEP images can match standard pathology in women with cervical lesions, including those living with HIV.
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Easier cervical cancer screening with self-collected HPV tests at safety-net clinics
This project will test whether offering primary high-risk HPV testing with self-collected samples increases cervical cancer screening for people aged 25–65 who get care at participating Texas safety-net clinics.
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Robotic bronchoscopic ablation for small peripheral lung tumors
This registry collects information on people with primary or metastatic peripheral lung tumors who have robotic-assisted bronchoscopic ablation to see how safe the procedure is and how well it controls tumors.
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Surgical techniques for treating pain after cancer-related amputations
This study is testing two different surgical methods to see if they can help cancer patients who have had amputations feel less pain in their residual limbs and reduce phantom limb pain.
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REGN5678 with cemiplimab for metastatic castration-resistant prostate cancer
This trial tests whether combining REGN5678 (a PSMAxCD28 bispecific antibody) with cemiplimab (an anti‑PD‑1 drug) is safe and shows signs of activity in men with metastatic castration‑resistant prostate cancer who have progressed after prior therapies.
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Olverembatinib monotherapy for adults with newly diagnosed chronic-phase CML
We are testing whether olverembatinib can control disease and produce deep molecular responses in adults newly diagnosed with chronic-phase CML.
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Detoxifying metals during therapy for acute myeloid leukemia
This study is testing if using metal detox treatments along with standard therapy can help people with acute myeloid leukemia live longer and have better treatment results.
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Optimized cord blood transplantation for high-risk blood cancer patients needing a second transplant
This study is testing a new approach using cord blood transplants for patients with high-risk blood cancers who need a second transplant to see if it helps them live longer and have better outcomes.
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Ustekinumab for immune checkpoint inhibitor-related diarrhea and colitis in cancer patients
This will test whether ustekinumab can control immune-related diarrhea and colitis in adults receiving immune checkpoint inhibitors for solid tumors.
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Psilocybin-assisted psychotherapy for depression and anxiety in cancer survivors
This trial tests whether psilocybin-assisted psychotherapy can help cancer survivors who are dealing with depression and/or anxiety.
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Helping older men with prostate cancer make decisions about surveillance
This study tests a new educational tool to help older men with localized prostate cancer decide if they should keep or change their active surveillance plan.
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Ziftomenib plus quizartinib dose-finding for relapsed/refractory AML with NPM1, KMT2A, or NUP98 alterations
This trial tests an all-oral combination of ziftomenib and quizartinib in adults with relapsed or refractory AML that has NPM1 mutations, KMT2A rearrangements, or NUP98 rearrangements.
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Clinic-based food farmacy and digital cooking program for cancer survivors
This program will test a clinic-linked food farmacy plus a digital culinary medicine course to try to improve diet and food security for food-insecure cancer survivors.
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Pre-surgery tirzepatide weight loss for overweight or obese men with intermediate-risk prostate cancer
This will try tirzepatide to help men with intermediate-risk prostate cancer lose weight before prostate removal surgery.
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Topical capsaicin for pain and walking problems from chemotherapy-related peripheral neuropathy
This will try an 8% capsaicin patch on adults with chemotherapy-related peripheral neuropathy to see if it lowers pain and improves walking.
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New tool to help lung cancer patients understand their illness better
This study tests a new tool to help lung cancer patients better understand their illness and treatment options compared to regular care.
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CHOICES: How different ways of explaining treatment options affect care planning for advanced cancer
This project will test different ways of explaining risks, benefits, time commitment, prognosis, doctors' recommendations, and costs to people with advanced cancer to see if that information changes their preference for palliative systemic therapy.
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Patient-specific 3D-printed breast molds for shaping tissue during autologous reconstruction
This project will test whether 3D-printed, patient-specific breast molds help surgeons shape tissue faster and more consistently during autologous breast reconstruction for adults after mastectomy.
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Tofacitinib cream for treating early-stage Cutaneous T-cell Lymphoma
This study is testing if a new cream can help people with early-stage Cutaneous T-cell Lymphoma feel better and improve their skin after 12 weeks of treatment.
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Program for early detection and management of side effects in metastatic cancer patients
This study tests a smartphone program that helps people with metastatic cancer spot and manage side effects from their treatment early on to see if it reduces the chances of stopping therapy due to these issues.
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Triplet combination of Relatlimab, Nivolumab, and Ipilimumab in first-line metastatic melanoma
A first-line trial tests whether a three-drug combo can help people with metastatic melanoma, starting at a recommended dose.
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Testing ivonescimab for recurrent glioblastoma
This study is testing a new treatment called ivonescimab to see if it can help adults with recurrent glioblastoma feel better and manage their disease after other treatments have failed.
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Using olutasidenib as maintenance therapy after stem cell transplant for patients with IDH1-mutated myeloid malignancies
This study is testing if olutasidenib can help prevent relapse in patients with IDH1-mutated myeloid cancers after they have had a stem cell transplant.
Showing recruiting studies first, then the newest. Describe your situation to find the ones that fit you.
Quick answers
How many clinical trials run by M.D. Anderson Cancer Center are recruiting right now?
509, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.
Where are these trials running?
In 18 countries. The most sites are in United States (509 trials), Canada (2 trials), Colombia (1 trial), Spain (1 trial), Italy (1 trial). Each study page lists its sites and which ones are recruiting.
What phases are they in?
Phase 2: 156, Phase 1: 75, Phase 1/2: 49, Early Phase 1: 7. Trials with no phase listed are usually device, behavioural or observational studies.
How do I join one?
Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.
Find the studies that fit you
A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.