Shared decision tool to help choose the levonorgestrel IUD for preventing endometrial cancer

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study uses a two-phase, mixed-methods approach to build and test a personalized shared decision-making tool focused on the levonorgestrel-releasing intrauterine system (LNG-IUS) for primary prevention of endometrial cancer. Phase 1 will use interviews and surveys with unaffected and affected women plus clinicians to identify decisional needs, values, and preferences. Phase 2 will develop an English and Spanish web-based tool that includes a personalized endometrial cancer risk calculator and will be field-tested with the target users. The tool is designed to prepare patients for clinician conversations and will not replace clinical consultations.

Why it matters

Who can join: the full rules

This study will include participants from three categories: Unaffected women, Affected women, and Healthcare Providers. The eligibility criteria for each group are listed below:

Inclusion Criteria:

1. Unaffected women

   1. Must be at least 18 years old
   2. Must read and speak English or Spanish
   3. Must be premenopausal
   4. Must not have a prior history of EC or complex atypical hyperplasia
   5. Must provide written, informed consent
   6. No physical, psychological, or cognitive impairments that would preclude participation in an interview as determined by the PI or study team member
2. Affected women

   1. Must be at least 18 years old
   2. Must read and speak English or Spanish
   3. Must have a prior history of EC or complex atypical hyperplasia
   4. Must provide written, informed consent
   5. No physical, psychological, or cognitive impairments that would preclude participation in an interview as determined by the PI or study team member
3. Healthcare Providers

   1. Physicians or advanced practice providers (physician assistants, nurse practitioners) from Family Medicine, Obstetrics \& Gynecology, Internal Medicine, or Endocrinology
   2. Must be at least 18 years old
   3. Must read and speak English or Spanish
   4. Must provide written, informed consent for qualitative interviews

Exclusion Criteria:

* N/A

Where it's running

• The Harris Health System (LBJ)
  Houston, Texas, United States Recruiting
• MD Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Larissa A Meyer, MD — M.D. Anderson Cancer Center
• Study coordinator: Larissa A Meyer, MD
• Email: lmeyer@mdanderson.org
• Phone: 713-745-0973

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Personalized navigation to support rural and Black women with endometrial cancer

  This pilot tests a tailored patient-navigation program to help rural and Black patients with endometrial cancer access care and services.

  Recruiting UNC Lineberger Comprehensive Cancer Center · Chapel Hill, North Carolina · NCT07927244

• CR-002 study in adults with advanced solid tumors

  This trial tests CR-002 as a single therapy to see if it is safe and tolerable in adults with locally advanced or metastatic solid tumors

  Recruiting at 3 sites Phase 1/2 Crescent Biopharma, Inc. · Austin, Texas and 2 other locations · NCT07909031

• Methylation markers in self-samples to help detect gynecological cancers

  This study tests whether self-collected urine and vaginal samples can reveal DNA methylation or other genetic markers that indicate endometrial, ovarian, vulvar, or vaginal cancers in women who are at risk or have postmenopausal bleeding.

  Recruiting Universiteit Antwerpen · Edegem, Antwerp · NCT07902375

• One-Finger Technique to identify the left upper ureter during para-aortic lymphadenectomy

  This study tests a new surgical method to help surgeons find the left upper ureter during open para-aortic lymphadenectomy in women with gynecologic cancers.

  Recruiting Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University · Guangzhou, Guangdong · NCT07895212

• Liquid biopsy screening for early endometrial cancer in regional China

  A non-invasive blood test using cell-free DNA is being tested to see if it can detect early endometrial cancer and tell apart benign from malignant uterine lesions.

  Recruiting Guizhou Provincial People's Hospital · Guiyang, Guizhou · NCT07892755

• Radiotherapy for gynecologic cancer with up to 10 metastatic sites

  This registry follows adults with gynecologic cancer who have 1 to 10 active metastatic lesions and are treated with radiotherapy as part of routine care to see how such treatments work in real-world settings.

  Recruiting Affidea Nu-med Center of Oncological DIagnostics and Therapy · Zamość · NCT07883798

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.