Chaplain-clinician PEACE spiritual care for people with advanced cancer
Official title: A Chaplain-clinician Led Spiritual Care (PEACE) Intervention on Spiritual/Religious Beliefs Related to Medical Care in Patients With Advanced Cancer: a Pilot Clinical Trial
Run by M.D. Anderson Cancer Center · NCT07246954 · Data updated 2026-11-12
This pilot will try a chaplain-clinician spiritual care program (PEACE) to see if it is feasible, acceptable, and can change how people with advanced cancer let their religious beliefs influence medical decisions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 60 (estimated) |
| Sponsor | M.D. Anderson Cancer Center Academic / other |
| Locations | 1 site (Houston, Texas) |
| Status | Recruiting |
| Started | December 22, 2025 |
| Main results expected | January 1, 2027 |
| Study ends | January 1, 2029 |
| Registry record updated | September 25, 2026 |
| Trial ID | NCT07246954 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are English-speaking adults with locally advanced, metastatic, recurrent, or incurable cancer seen by MD Anderson's supportive/palliative care mobile team who report that their faith strongly influences their willingness to accept medical treatments and have KPS ≥30% and intact cognition.
✕Probably not a fit
Patients unlikely to benefit include those without spiritual/religious concerns affecting care, non-English speakers, those with significant cognitive impairment, or those too ill to participate (very low performance status).
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This single-center pilot uses a chaplain-clinician delivered PEACE intervention (Perception, Exploring, Addressing, Compassionate Connection, Embracing) in patients with advanced cancer seen by the supportive/palliative care mobile team at MD Anderson. Phase 1 examines feasibility (≥70% participation in all sessions) and acceptability (≥70% satisfied and ≥70% would recommend) in a single-arm cohort. Phase 2 examines within-group change on a key Religious Beliefs in End-of-Life Medical Care (RBEC) item about accepting every possible medical treatment for faith reasons, comparing PEACE participants and usual care over a short follow-up (baseline to ~2 days post-intervention). Eligible participants are English-speaking adults with advanced cancer, Karnofsky performance status ≥30%, intact cognition, and who endorse religious beliefs that influence treatment decisions.
Why it matters
Potential benefit: If successful, the PEACE intervention could help patients feel more supported and less conflicted about medical decisions by aligning care with their spiritual and religious values.
How similar studies have gone: Prior chaplain- and spiritual-care interventions in palliative settings have shown some benefits for spiritual well-being and coping, but the specific chaplain-clinician PEACE model is novel and not yet extensively tested.
Who can join: the full rules
Show full inclusion / exclusion criteria
Eligibility Criteria 1. Participants with advanced cancer (locally advanced, metastatic, recurrent, or incurable) seen by the participant supportive/palliative care mobile team at MD Anderson Cancer Center. 2. Respond "somewhat to A great deal" to the question in the RBEC questionnaire "I will accept every possible medical treatment because my faith tells me to do everything I can to stay alive longer". 3. Participant s aged 18 years or over. 4. Karnofsky performance status ≥30% at time of inclusion into study. 5. Normal cognitive status as determined by the supportive care clinicians based on the ability to understand the nature of the study and consent process. 6. Only English-speaking, as determined by their ability to understand the informed consent, the intervention, and the assessment tools.
Where it's running
-
MD Anderson Cancer Center
Houston, Texas, United States Recruiting
Study contacts
- Principal investigator: Marvin Delgado Guay, MD — M.D. Anderson Cancer Center
- Study coordinator: Marvin Delgado Guay, MD
- Email: marvin.delgado@mdanderson.org
- Phone: 713-745-8190
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Concise coaching to guide decisions for advanced cancer patients considering palliative procedures
A coaching program delivered by lay providers will test whether it helps adults with advanced cancer make better, patient-aligned decisions about palliative surgeries or similar interventions.
-
Primary Palliative Care: A Feasibility Project for Family Health Units
This feasibility trial tests a GP training program plus a structured 12-week palliative-care visit plan to see if it can be carried out in primary care for adults with advanced illness.
-
Virtual Group Resilient Living for Advanced Cancer
A group-based online program tests whether seven weekly sessions can reduce anxiety and fatigue and improve quality of life for adults with advanced cancer.
-
IV contrast-enhanced CBCT with HyperSight for image guidance in advanced cancer radiotherapy
This study tests whether giving IV contrast during cone-beam CT helps doctors see the tumor better during radiotherapy in people with advanced cancer.
-
Single-session celiac plexus SBRT using a simulation-free adaptive workflow for cancer-related pain
A pilot test to see if a one-day, simulation-free adaptive radiotherapy process can safely deliver celiac plexus SBRT to adults with advanced pancreatic or other cancers.
-
UI-102 in advanced cancers (phase 1/2) first-in-human
A first-in-human study tests UI-102, given to adults with advanced solid tumors to see if it is safe and shows signs of benefit.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.