Clinical trial Recruiting at 1 site Interventional Ages 18 and up

Chaplain-clinician PEACE spiritual care for people with advanced cancer

Official title: A Chaplain-clinician Led Spiritual Care (PEACE) Intervention on Spiritual/Religious Beliefs Related to Medical Care in Patients With Advanced Cancer: a Pilot Clinical Trial

Run by M.D. Anderson Cancer Center · NCT07246954 · Data updated 2026-11-12

This pilot will try a chaplain-clinician spiritual care program (PEACE) to see if it is feasible, acceptable, and can change how people with advanced cancer let their religious beliefs influence medical decisions.

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Quick facts

Study typeInterventional
Ages18 Years and up
SexAll
Enrollment60 (estimated)
SponsorM.D. Anderson Cancer Center
Academic / other
Locations1 site (Houston, Texas)
StatusRecruiting
StartedDecember 22, 2025
Main results expectedJanuary 1, 2027
Study endsJanuary 1, 2029
Registry record updatedSeptember 25, 2026
Trial IDNCT07246954 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Ideal candidates are English-speaking adults with locally advanced, metastatic, recurrent, or incurable cancer seen by MD Anderson's supportive/palliative care mobile team who report that their faith strongly influences their willingness to accept medical treatments and have KPS ≥30% and intact cognition.

Probably not a fit

Patients unlikely to benefit include those without spiritual/religious concerns affecting care, non-English speakers, those with significant cognitive impairment, or those too ill to participate (very low performance status).

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This single-center pilot uses a chaplain-clinician delivered PEACE intervention (Perception, Exploring, Addressing, Compassionate Connection, Embracing) in patients with advanced cancer seen by the supportive/palliative care mobile team at MD Anderson. Phase 1 examines feasibility (≥70% participation in all sessions) and acceptability (≥70% satisfied and ≥70% would recommend) in a single-arm cohort. Phase 2 examines within-group change on a key Religious Beliefs in End-of-Life Medical Care (RBEC) item about accepting every possible medical treatment for faith reasons, comparing PEACE participants and usual care over a short follow-up (baseline to ~2 days post-intervention). Eligible participants are English-speaking adults with advanced cancer, Karnofsky performance status ≥30%, intact cognition, and who endorse religious beliefs that influence treatment decisions.

Why it matters

Potential benefit: If successful, the PEACE intervention could help patients feel more supported and less conflicted about medical decisions by aligning care with their spiritual and religious values.

How similar studies have gone: Prior chaplain- and spiritual-care interventions in palliative settings have shown some benefits for spiritual well-being and coping, but the specific chaplain-clinician PEACE model is novel and not yet extensively tested.

Who can join: the full rules

Show full inclusion / exclusion criteria
Eligibility Criteria

1. Participants with advanced cancer (locally advanced, metastatic, recurrent, or incurable) seen by the participant supportive/palliative care mobile team at MD Anderson Cancer Center.
2. Respond "somewhat to A great deal" to the question in the RBEC questionnaire "I will accept every possible medical treatment because my faith tells me to do everything I can to stay alive longer".
3. Participant s aged 18 years or over.
4. Karnofsky performance status ≥30% at time of inclusion into study.
5. Normal cognitive status as determined by the supportive care clinicians based on the ability to understand the nature of the study and consent process.
6. Only English-speaking, as determined by their ability to understand the informed consent, the intervention, and the assessment tools.

Where it's running

  • MD Anderson Cancer Center
    Houston, Texas, United States
    Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.