Geniculate Artery Embolization for Knee Osteoarthritis in Cancer Patients

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a prospective observational study evaluating the change in knee pain and disability after geniculate artery embolization (GAE) in cancer patients with symptomatic knee osteoarthritis. Participants will be followed annually to observe trajectories, healthcare use, and barriers to care, with deliberate oversampling of cancer survivors over 10 years. The primary objective is to measure mean change in the total WOMAC score from baseline to 12 months after receiving standard-of-care GAE. Eligible participants are adults aged 40 and older with radiographically confirmed Kellgren-Lawrence grade 2-4 OA, chronic knee pain despite conservative treatments, and an active cancer diagnosis at MD Anderson.

Why it matters

Who can join: the full rules

Inclusion Criteria

1. Age ≥40 years with no upper age restriction, provided performance status permits procedural candidacy
2. Symptomatic mild-to-severe knee osteoarthritis (Kellgren-Lawrence grade 2-4) on radiographs within 6 months of enrollment
3. Chronic knee pain (NRS ≥4/10) for ≥3 months despite conservative treatment including steroid injections, physical therapy, and/or analgesic medications
4. Inadequate candidate for or refusal of surgical intervention (e.g., total knee arthroplasty) due to cancer-related comorbidities, ongoing treatment, or participants preference
5. Active cancer diagnosis (solid tumor or hematologic malignancy) confirmed at MD Anderson Cancer Center

Exclusion Criteria

* Active joint infection or suspected septic arthritis
* Life expectancy \<6 months
* Prior knee arthroplasty in the index knee
* Coagulopathy or contraindications to angiography
* GFR \<30 mL/min/1.73m²
* Peripheral artery disease with stenosis or occlusion of lower extremity vasculature (relative contraindication per SIR standards, given geniculate artery collateral perfusion role)
* Radiographically normal knee joint (KL grade 0-1) - alternative etiologies should be sought
* Known active autoimmune/inflammatory arthropathy (e.g., rheumatoid arthritis, psoriatic arthritis)
* Any medical condition or clinical abnormality that, per investigator judgment, precludes safe participation in and completion of the study

Where it's running

• UT MD Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Nicolas J Cardenas, MD — UT MD Anderson Cancer Center
• Study coordinator: Nicolas J Cardenas, MD
• Email: NJCardenas@mdanderson.org
• Phone: 713-794-4404

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.