Nano-pulsed Field Ablation for Benign Thyroid Nodules

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study follows adults with biopsy-confirmed benign thyroid nodules undergoing ultrasound-guided nsPFA as part of routine care. It tracks changes in nodule volume over time and assesses patient quality of life after treatment. Ultrasound characteristics and any complications (minor or major) are recorded to understand safety and imaging correlates. No experimental interventions beyond standard clinical care are performed, and findings will inform future practice patterns.

Why it matters

Who can join: the full rules

Eligibility Criteria

* Scheduled to undergo ultrasound guided nsPFA as standard of care
* Age 18 to 80 years.
* Capable of providing independent consent.
* Presence of biopsy-confirmed benign thyroid nodule , defined as one of the following:

  * Benign FNA X 2 or
  * Benign US guided FNA X 1 + benign thyroid nodule ultrasound appearance (TI-RADS 2) or
  * Benign FNA X 1 and radiographic/laboratory evidence of functional nature
* Nodule measuring \>2cm in greatest dimension
* Presence of compressive symptoms reasonably attributable to thyroid nodule (i.e. pressure sensation, dysphagia, dysphonia, respiratory distress)
* No abnormal cervical lymph nodes during screening visit .

Exclusion Criteria

* Age \<18
* Patients considered unsuitable for nsPFA by the treating physician

Where it's running

• MD Anderson Cancer Center
  Houston, Texas, United States Recruiting

Study contacts

• Principal investigator: Victoria E Banuchi, MD — M.D. Anderson Cancer Center
• Study coordinator: Victoria E Banuchi, MD
• Email: vebanuchi@mdanderson.org
• Phone: 346-217-8668

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Factors Linked to Slow Heart Rate After Pulsed Field Ablation for Atrial Fibrillation

  This study looks for factors that might cause bradycardia during the hospital stay after AF ablation using pulsed field technology.

  Recruiting Wroclaw Medical University · Wroclaw, Lower Silesian Voivodeship · NCT07809347

• Pulsed Field Ablation Outcomes in Atrial Fibrillation: Randomized Comparison to Traditional Ablation

  This study tests pulsed field ablation versus conventional radiofrequency ablation in adults with atrial fibrillation to see which method better preserves heart rhythm.

  Recruiting China National Center for Cardiovascular Diseases · Beijing, Beijing Municipality · NCT07601763

• A New Ultrasound Probe for Thyroid Imaging with AI Analysis

  Researchers are testing a new ultrasound probe called Sound Blade to see if it helps image benign thyroid nodules during standard ultrasound exams.

  Recruiting Sound Blade Medical Inc. · Dartmouth, Nova Scotia · NCT07488585

• Thyroid artery embolization to relieve compressive goiters.

  This will see if blocking blood flow to the thyroid (thyroid artery embolization) can safely shrink nodular goiters and relieve breathing or swallowing problems in adults who are ineligible for or decline surgery.

  Recruiting Centre de recherche du Centre hospitalier universitaire de Sherbrooke · Sherbrooke, Quebec · NCT07360587

• Concomitant Pulsed Field Ablation and Left Atrial Appendage Closure in AF Patients

  In patients with atrial fibrillation who need both ablation and left atrial appendage closure, this study tests doing both procedures in a single intervention using FARAPULSE PFA and a WATCHMAN FLX device.

  Recruiting at 10 sites Boston Scientific Corporation · Aalst and 10 other locations · NCT07349121

• Lavender aromatherapy for anxiety and pain during awake ear, nose, and throat procedures

  This tests whether lavender aromatherapy used during awake ear, nose, and throat clinic procedures can reduce anxiety and pain in adults.

  Recruiting Cedars-Sinai Medical Center · Los Angeles, California · NCT07299474

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.