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Clinical trials and research at Leiden University Medical Center

• 63Clinical trials
• 2NIH research projects
• 1New in 30 days
• 28Countries

Newest trials

All recruiting trials (63)

• In-situ vs Ex-situ Liver Preservation for Transplants

  This trial tests whether in-situ aNRP preservation works better than ex-situ DHOPE (with or without COR-NMP) for livers from donors after circulatory death in people awaiting liver transplantation.

  Recruiting at 2 sites Leiden University Medical Center · Groningen and 2 other locations · NCT07899853

• Managing pasireotide-related high blood sugar in acromegaly with a ketogenic diet

  This study tests whether a very-low carbohydrate ketogenic diet can help lower HbA1c and fasting glucose in adults with acromegaly who develop high blood sugar while taking pasireotide.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07866846

• Combined e-Learning and Virtual Reality Training to Improve Rheumatology Provider Communication

  This trial tests whether a combined online course and VR training helps rheumatology providers communicate better with patients and whether patients rate their communication more highly after training.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07835256

• Low-Field MRI in Emergency Stroke Care

  This study tests whether a portable low-field MRI can help detect acute stroke in patients arriving with suspected stroke.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07702968

• Registry of Minimally Invasive Cancer Treatments Using Spectral Angio-CT Guidance

  This registry collects data from adults undergoing image-guided, minimally invasive cancer treatments to see if spectral angio-CT guidance helps predict outcomes and improve planning.

  Recruiting Leiden University Medical Center · Lyon, Auvergne-Rhône-Alpes and 2 other locations · NCT07636148

• Nerve surgery to treat painful amputation neuromas

  This study tests whether nerve-surgery techniques like fascicular split or targeted muscle reinnervation can relieve pain in adults with painful neuromas after an amputation.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07605754

• Laser speckle imaging to monitor leg perfusion before, during and after revascularization

  This study tries a non-invasive laser speckle imaging method to see if it can measure blood flow in the legs of people having lower-extremity revascularization.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07558174

• Belimumab to mobilize memory B cells to help delistings for highly sensitized kidney transplant candidates

  A short belimumab course is being tested to see if it can reveal memory B cells that target donor HLAs, helping to decide which donors to exclude and potentially speed up getting a transplant for highly sensitized patients.

  Recruiting Phase 2 Leiden University Medical Center · Leiden · NCT07539857

• Making Diabetes Care Fit for Young Adults With Type 1 Diabetes

  This study tests whether using the Making Care Fit tool with clinicians helps 18- to 30-year-olds with type 1 diabetes better align care with their daily lives compared to usual care.

  Recruiting at 2 sites Leiden University Medical Center · Leiden, South Holland and 1 other locations · NCT07498738

• Do abdominal aneurysms occur in people who had a ruptured brain aneurysm

  This study checks whether people who had a ruptured brain aneurysm also have an abdominal aortic aneurysm using an abdominal ultrasound.

  Recruiting Leiden University Medical Center · Leiden · NCT07312565

• ICU‑Recover Box 2.0: smart home monitoring for people after an ICU stay.

  This pilot tests whether a home ICU‑Recover Box with smart sensors can help people recovering from an ICU stay detect problems early and support recovery during the year after discharge.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT07162948

• Monitoring diaphragm electrical activity and breathing effort during ventilator weaning

  We will see if surface diaphragm EMG, esophageal pressure, and oxygen use measured during a spontaneous breathing trial can predict who will fail to wean from the ventilator in the ICU.

  Recruiting Leiden University Medical Center · Leiden · NCT07109570

• Objective measurement of skin pigmentation with colorimetry and multispectral imaging

  We will test whether non-invasive imaging (colorimetry, multispectral imaging, and line-field confocal OCT) can provide reliable, objective skin pigmentation measurements for adults with healthy skin or skin conditions.

  Recruiting Leiden University Medical Center · Leiden, Leiden · NCT07091604

• Taking cabozantinib on a skip-days schedule instead of lowering the daily dose

  This test tries whether taking cabozantinib on a skip-days schedule gives similar drug levels, side effects, and quality of life for adults with metastatic renal cell carcinoma who are already on 20–40 mg daily.

  Recruiting Phase 2 Leiden University Medical Center · Leiden, South Holland · NCT07077161

• Personalized cancer treatment using an integrated decision-making approach

  This study tests an Integrated Oncological Decision-making Model to see if combining treatment options, a patient's overall health, and their personal goals helps adults with cancer get more personalized treatment decisions.

  Recruiting at 4 sites Leiden University Medical Center · Groningen and 3 other locations · NCT07046884

• SKINERGY: deep biomarker profiling of immune-driven skin diseases in dermatology clinics

  This project will test whether detailed blood, tissue, imaging, and patient-reported biomarker profiles in adults with several immune-related skin conditions can find patterns that distinguish disease types and predict who responds to treatment.

  Recruiting Leiden University Medical Center · Nijmegen, Gelderland and 7 other locations · NCT07021495

• 18F-FAPI PET/CT and laparoscopy for staging advanced stomach cancer

  This trial tests whether an 18F-FAPI PET/CT scan, used with laparoscopy, can better find spread of advanced stomach cancer and help doctors avoid unnecessary surgery.

  Recruiting Phase 2/3 Leiden University Medical Center · Almelo and 9 other locations · NCT07018661

• Evaluating cardiac resynchronization therapy effects in adults with congenital heart disease

  This study is trying to see if cardiac resynchronization therapy can help adults with congenital heart disease feel better and improve their heart function.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06969924

• Impact of catheter replacement on urinary tract infections

  This study is testing if changing bladder catheters during treatment for urinary tract infections helps people avoid getting infections again compared to keeping their current catheters.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06936631

• Evaluating the effectiveness of SGLT2 inhibitors in adults with congenital heart disease

  This study is trying to see if a new type of diabetes medication can help adults with congenital heart disease feel better and manage their heart failure symptoms.

  Recruiting at 11 sites Leiden University Medical Center · Baltimore, Maryland and 10 other locations · NCT06932081

• Registry for patients with cardiac amyloidosis

  This study is collecting information from adults with cardiac amyloidosis to see how the disease progresses and to help improve treatment and care for patients.

  Recruiting at 6 sites Leiden University Medical Center · Bruges and 5 other locations · NCT06894290

• Comparing catheter-directed thrombectomy to thrombolysis for high-risk pulmonary embolism

  This study is testing if a new procedure called catheter-directed thrombectomy can help people with high-risk pulmonary embolism do better than the standard treatment of full-dose thrombolysis.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06833827

• Using avacopan for treating ANCA-associated vasculitis in real-world settings

  This study looks at how well avacopan works for treating people with ANCA-associated vasculitis in real-life situations across Europe.

  Recruiting Leiden University Medical Center · Leiden · NCT06794827

• Evaluating outcomes in patients with moderate mixed aortic valve disease

  This study is trying to see if patients with moderate mixed aortic valve disease have different death rates compared to those with severe aortic stenosis or regurgitation, and if they might benefit from treatment even if they don’t have severe symptoms.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06789211

• EMDR treatment for fear of cancer recurrence in familial melanoma patients

  This study is testing if EMDR therapy can help patients with familial melanoma feel less afraid of their cancer coming back.

  Recruiting at 2 sites Leiden University Medical Center · Leiden, South Holland and 1 other locations · NCT06767332

• Using smartphone recordings to assess symptoms of Myasthenia Gravis

  This study is testing if smartphone recordings can help track symptoms like speech problems and fatigue in people with Myasthenia Gravis.

  Recruiting Leiden University Medical Center · Leiden, South Holland and 1 other locations · NCT06743490

• Preventing pain after lower limb amputation using targeted muscle reinnervation

  This study is testing if a new technique called Targeted Muscle Reinnervation can help reduce pain after lower limb amputation compared to standard nerve handling.

  Recruiting Leiden University Medical Center · Amsterdam, North Holland and 6 other locations · NCT06719245

• Evaluating a new method to improve decision making in cancer care

  This study is testing a new approach called MetroMapping to see if it helps patients with breast, prostate, and melanoma cancers make better decisions about their treatment.

  Recruiting at 3 sites Leiden University Medical Center · Vejle and 2 other locations · NCT06685562

• Comparing two pacing methods for heart failure in patients with atrial fibrillation

  This study is testing whether a new pacing method for the heart can work better than the standard method for people with heart failure and atrial fibrillation.

  Recruiting Leiden University Medical Center · Aarhus N, Aarhus N and 1 other locations · NCT06620705

• Training program for children with anxiety and shyness

  This study is testing a program called 'Learn to Dare!' to help children aged 8 to 18 who feel anxious or shy build confidence and face their fears.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06609824

• Calibration of esophageal balloon catheter for patients on mechanical ventilation

  This study is testing how to better calibrate a special balloon used in the esophagus to measure pressure in patients on mechanical ventilation, to see if it helps improve their care.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06584604

• Personalized blood thinner treatment for hip and knee replacement patients

  This study is testing if personalized blood thinner treatments can better prevent blood clots and bleeding in patients getting hip or knee replacements compared to standard treatments.

  Recruiting at 12 sites Phase 4 Leiden University Medical Center · Apeldoorn, Gelderland and 12 other locations · NCT06581965

• Home microsampling to monitor cancer drug levels

  This tests whether tiny blood samples taken at home can reliably measure levels of certain oral and injectable cancer drugs in adults using those medicines.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06545292

• Helping patients stop smoking before spine surgery

  This study is testing whether helping patients quit smoking before spine surgery can lead to better recovery and results compared to those who keep smoking or don’t smoke at all.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06361459

• Optimizing stroke identification by ambulance paramedics

  This study is testing how well ambulance paramedics can identify strokes using different methods to see which one works best for patients.

  Recruiting Leiden University Medical Center · Leiden · NCT06332989

• Upfront dose-reduced chemotherapy for older patients with metastatic colorectal cancer

  This study is testing whether giving lower doses of chemotherapy can help older patients with advanced colorectal cancer live longer and feel better compared to the standard full doses.

  Recruiting at 10 sites Phase 3 Leiden University Medical Center · 's-Hertogenbosch and 35 other locations · NCT06275958

• New methods for diagnosing and preventing leprosy

  This study is testing new ways to find and prevent leprosy in people who have been close to someone diagnosed with it, using a single-dose antibiotic and a new test to spot the disease early.

  Recruiting Leiden University Medical Center · Nilphamari · NCT06222372

• Non-invasive method to estimate portal and hepatic vein pressure

  This study is testing a new, non-invasive MRI method to see if it can accurately measure blood pressure in the liver for people with serious liver disease.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06210178

• Using AI to improve treatment for liver tumors

  This study is testing whether using artificial intelligence can help doctors choose the best treatments and predict outcomes for patients with liver tumors undergoing thermal ablation.

  Recruiting Leiden University Medical Center · Leiden · NCT06179602

• Comparing two antibiotic treatments for joint infections caused by Staphylococcus

  This study tests whether a combination of two antibiotics can work better than just one to treat joint infections caused by Staphylococcus in adults with hip or knee infections.

  Recruiting at 11 sites Phase 4 Leiden University Medical Center · Leiden, Zuid Hollans and 12 other locations · NCT06172010

• Investigating how brain lithium levels affect treatment response in bipolar disorder

  This study is testing if measuring lithium levels in the brain can help predict how well adults with bipolar disorder will respond to lithium treatment.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT06134349

• Targeted therapy for BRAF-mutated anaplastic thyroid cancer

  This study is testing a new treatment using two targeted drugs to see if it helps patients with a specific type of thyroid cancer have better surgery outcomes.

  Recruiting Phase 2 Leiden University Medical Center · Leiden, South Holland · NCT06079333

• Investigating the relationship between white matter hyperintensity shape and brain clearance in dementia

  This study is trying to see how the shape of certain brain changes in older adults with small vessel disease relates to their thinking skills and dementia.

  Recruiting Leiden University Medical Center · Leiden · NCT06010511

• Fluorescence-guided surgery for pancreatic cancer

  This study is testing a special imaging technique to help surgeons see pancreatic tumors better during surgery for patients who have had treatment before their operation.

  Recruiting Phase 2 Leiden University Medical Center · Leiden · NCT05984810

• Using Denosumab to treat Fibrous Dysplasia and McCune-Albright Syndrome in adults

  This study is testing if Denosumab can help adults with Fibrous Dysplasia and McCune-Albright Syndrome feel less pain and improve their condition compared to a placebo.

  Recruiting Phase 4 Leiden University Medical Center · Leiden · NCT05966064

• Comparing diaphragm function measurement techniques in infants on respiratory support

  This study is testing two ways to measure how well the diaphragm works in infants on breathing support to see which method is more reliable for checking their readiness to breathe on their own.

  Recruiting Leiden University Medical Center · Leiden · NCT05965830

• Testing a new Shigella vaccine with an adjuvant in healthy adults

  This study is testing a new Shigella vaccine to see if it works better with a special booster in healthy adults.

  Recruiting Phase 1 Leiden University Medical Center · Leiden · NCT05961059

• Investigation of selective fetal growth restriction in monochorionic twins

  This study is trying to find better ways to understand and manage growth problems in one twin of monochorionic twins during pregnancy, while also checking how these issues affect the twins' development later on.

  Recruiting at 5 sites Leiden University Medical Center · Boston, Massachusetts and 5 other locations · NCT05952583

• Effect of tactile stimulation on oxygen levels in preterm infants

  This study tests if gently stroking the feet and back of preterm infants right after birth can help improve their oxygen levels.

  Recruiting at 42 sites Leiden University Medical Center · Graz and 42 other locations · NCT05942924

• Comparing Methylprednisolone Injections to Placebo for Treating Vertigo in Meniere's Disease

  This study is testing whether injections of a medication called methylprednisolone can help people with Meniere's disease feel less dizzy compared to a placebo.

  Recruiting Phase 3 Leiden University Medical Center · Leiden, South Holland · NCT05851508

• Using prednisolone to help women with unexplained recurrent miscarriages

  This study is testing if taking prednisolone can help women who have had multiple unexplained miscarriages have a successful pregnancy.

  Recruiting Phase 4 Leiden University Medical Center · Leiden, South Holland · NCT05725512

• Comparing surgery and IVF for treating colorectal endometriosis and subfertility

  This study is testing whether surgery for colorectal endometriosis helps women with fertility issues and severe pain have more babies compared to using IVF or ICSI.

  Recruiting at 10 sites Leiden University Medical Center · Eindhoven and 9 other locations · NCT05677269

• Adaptive Proton Therapy for Cervical Cancer

  This study is testing if a new type of radiation therapy called intensity modulated proton therapy can help women with advanced cervical cancer have fewer side effects and better outcomes compared to standard radiation treatments.

  Recruiting Leiden University Medical Center · Leiden and 1 other locations · NCT05406856

• Impact of Phlebotomy on Heart Rate in Patients with Polycythemia

  This study is testing how having blood drawn regularly affects heart rate and overall well-being in people with polycythemia.

  Recruiting Leiden University Medical Center · Leiden, South Holland · NCT05396170

• Comparing treatment strategies for advanced prostate cancer

  This study is testing if a personalized treatment plan that includes taking breaks from hormone therapy can help men with advanced prostate cancer live better and longer compared to taking the medication every day.

  Recruiting at 19 sites Phase 2 Leiden University Medical Center · Albury, New South Wales and 18 other locations · NCT05393791

• Repeated GON injections for chronic cluster headache relief

  This study is testing if repeated injections in the back of the head can help people with chronic cluster headaches have fewer headache attacks.

  Recruiting at 2 sites Phase 3 Leiden University Medical Center · Leiden and 1 other locations · NCT05324748

• Mapping blood vessel characteristics in brain tumors

  This study is testing a new MRI technique to see if it can help doctors understand the blood vessels in brain tumors without needing to do a biopsy.

  Recruiting Leiden University Medical Center · Leiden and 1 other locations · NCT05274919

• Comparing two antibiotic combinations for treating complicated MRSA carriage

  This study is testing whether a combination of doxycycline and rifampicin works better than trimethoprim and rifampicin to help adults get rid of complicated MRSA infections.

  Recruiting Leiden University Medical Center · Leiden · NCT05268120

• New treatments for endometrial cancer based on tumor genetics

  This study tests four different personalized treatments for endometrial cancer based on the genetic makeup of patients' tumors to see if they work better than standard therapies.

  Recruiting at 60 sites Phase 3 Leiden University Medical Center · Antwerp and 59 other locations · NCT05255653

• Using imaging to improve proton therapy for chordomas and chondrosarcomas

  This study is testing if using advanced imaging techniques can help improve proton therapy for patients with aggressive bone tumors called chordomas and chondrosarcomas by better targeting the tumors and protecting healthy tissue.

  Recruiting at 2 sites Leiden University Medical Center · Delft, South Holland and 1 other locations · NCT04832620

• Predicting success of epidural injections for sciatica treatment

  This study is trying to find out which factors can help predict how well epidural injections will work for people with sciatica caused by a herniated disc or spinal stenosis.

  Recruiting Leiden University Medical Center · Haarlem · NCT04540068

• Identifying immune markers in ovarian cancer patients

  This study is trying to find immune markers in women with ovarian cancer to see how they relate to treatment outcomes.

  Recruiting Leiden University Medical Center · Leiden · NCT03862677

• Comparing seizure treatments in glioma patients

  This study is testing which of two common seizure medications, levetiracetam or valproic acid, works better for people with glioma who have just had their first seizure.

  Recruiting at 4 sites Phase 4 Leiden University Medical Center · Amsterdam and 4 other locations · NCT03048084

NIH-funded research (2)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Why malaria vaccines work differently across communities

  Looking at how a person's environment and immune system affect whether a vaccine that targets the malaria parasite before it reaches the blood protects people living where malaria is common.

  NIH research Leiden University Medical Center · Leiden, Netherlands · NIH-11307568

• Understanding factors that affect malaria vaccine responses in different environments

  This study is looking at how different factors, like genetics and the environment, affect how well malaria vaccines work in various places, especially where malaria is common, to help improve vaccine effectiveness for everyone.

  NIH research Leiden University Medical Center · Leiden, Netherlands · NIH-11044113

Quick answers

How many clinical trials run by Leiden University Medical Center are recruiting right now?

63, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 28 countries. The most sites are in Netherlands (62 trials), Belgium (4 trials), Italy (3 trials), Germany (3 trials), Spain (3 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 5, Phase 4: 5, Phase 3: 4, Phase 1: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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