Home microsampling to monitor cancer drug levels

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

The study clinically validates an analytical method using dried blood spot microsampling to measure concentrations of a panel of oral targeted therapies and several monoclonal antibodies. It also tests the feasibility of patients collecting capillary samples at home for therapeutic drug monitoring. The rationale is that many oral oncolytics show large between-patient variability in blood levels, which can lead to under- or overdosing, and that convenient home sampling could reduce clinic burden and support personalized dosing. Microsampling of immune checkpoint inhibitors remains exploratory within this protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Willing and able to provide informed consent;
* 18 years of age or older;
* Using one or more of the following drugs: Cabozantinib, Pazopanib, Sunitinib, Lenvatinib, Imatinib, Abiraterone, Enzalutamide, Nivolumab, Ipilimumab, Pembrolizumab, Atezolizumab, Bevacizumab or Enfortumab vedotin

Exclusion Criteria:

* Not able to sample themselves using a finger prick

Where it's running

• Leiden University Medical Center
  Leiden, South Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Tom Van Der Hulle, MD PhD
• Email: t.van_der_hulle@lumc.nl
• Phone: 0031715263464

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.