Understanding factors that affect malaria vaccine responses in different environments
Official title: Baseline host and environmental factors that impact pre-erythrocytic malaria vaccine (hypo)responsiveness in endemic regions
Funded at Leiden University Medical Center · NIH-11044113 · Data updated 2026-11-12
This study is looking at how different factors, like genetics and the environment, affect how well malaria vaccines work in various places, especially where malaria is common, to help improve vaccine effectiveness for everyone.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Leiden University Medical Center NIH-funded |
| Lab location | 1 site (Leiden, Netherlands) |
| Project start | March 8, 2022 |
| Project end | February 28, 2027 |
| Funding year | 2025 |
| Award (this year) | $650,010 |
| NIH project number | 5U01AI165745-04 |
| Project ID | NIH-11044113 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals living in malaria-endemic regions, particularly those who have been vaccinated or are eligible for vaccination.
✕Less likely to help
Patients living in non-endemic regions or those who are not eligible for malaria vaccination may not benefit from this research.
What this research studies
This research investigates how various host and environmental factors influence the effectiveness of malaria vaccines in different populations, particularly in endemic regions. By examining immune responses through advanced 'omics' technologies, the study aims to identify why vaccine efficacy varies significantly across different countries and settings. The research will analyze both genetic and environmental influences on immune profiles to better understand their impact on vaccine responsiveness. This comprehensive approach seeks to develop a harmonized method for assessing immunological reactions to malaria vaccines.
Why it matters
Potential benefit: If successful, this research could lead to more effective malaria vaccines tailored to specific populations and environments, ultimately reducing the burden of malaria.
How similar studies have gone: Previous research has shown varying success in understanding vaccine responses through similar immunological approaches, indicating potential for breakthroughs in malaria vaccine efficacy.
Where this research is happening
-
Leiden University Medical Center
Leiden, Netherlands Active
Researchers
- Principal investigator: Yazdanbakhsh, Maria — Leiden University Medical Center
- Study coordinator: Yazdanbakhsh, Maria
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.