Evaluating outcomes in patients with moderate mixed aortic valve disease

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to assess the mortality rates of patients with moderate mixed aortic valve disease (MAVD) compared to those with isolated severe aortic stenosis (AS) and isolated severe aortic regurgitation (AR). The study will analyze clinical and echocardiographic characteristics to identify factors associated with increased mortality in this population. By examining a multi-center cohort, the research seeks to establish whether patients with moderate MAVD may benefit from aortic valve intervention, even in the absence of severe symptoms or left ventricular dysfunction.

Why it matters

Who can join: the full rules

Inclusion Criteria:

1. Patients with concomitant moderate AS and moderate AR
2. Patients with isolated severe AS
3. Patients with isolated severe AR

Exclusion Criteria:

1. Previous aortic valve surgery
2. Concomitant left valvular heart disease more than mild grade
3. Acute AR
4. Bad echocardiographic image quality

Where it's running

• Leiden University Medical Center
  Leiden, South Holland, Netherlands Recruiting

Study contacts

• Study coordinator: Nina Ajmone Marsan, MD, PhD
• Email: n.ajmone@lumc.nl
• Phone: 31715262020

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.