Non-invasive method to estimate portal and hepatic vein pressure
Non-Invasive Portal and Hepatic Vein Pressure Estimation: MRI-Guided Diagnostics for Chronic Liver Disease
This study is testing a new, non-invasive MRI method to see if it can accurately measure blood pressure in the liver for people with serious liver disease.
Quick facts
| Phase | Not applicable |
|---|---|
| Study type | Interventional |
| Enrollment | 50 (estimated) |
| Ages | 18 Years to 75 Years |
| Sex | All |
| Sponsor | Leiden University Medical Center Academic / other |
| Locations | 1 site (Leiden, South Holland) |
| Trial ID | NCT06210178 on ClinicalTrials.gov |
What this trial studies
This study aims to develop a non-invasive technique for estimating portal and hepatic vein pressure using advanced magnetic resonance imaging (MRI) methods. By employing four-dimensional flow MRI, the researchers seek to improve the accuracy of diagnosing portal hypertension, a serious complication of liver disease. The approach focuses on visualizing abdominal blood flow circulation and quantifying pressure gradients without the need for invasive procedures. This could lead to better prognostic and therapeutic strategies for patients with end-stage liver disease.
Who should consider this trial
Good fit: Ideal candidates for this study are adults aged 18 to 75 who are eligible for liver transplantation screening.
Not a fit: Patients with contraindications for MRI, such as claustrophobia or certain medical implants, may not benefit from this study.
Why it matters
Potential benefit: If successful, this method could provide a safer and more accurate way to diagnose portal hypertension, improving patient management and outcomes.
How similar studies have performed: While the use of advanced MRI techniques is gaining traction, this specific non-invasive approach for estimating portal and hepatic vein pressure is novel and has not been extensively tested in prior studies.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Eligible for liver transplantation (LT) screening (which excludes pregnancy). * Age ≥ 18 years and ≤ 75 (since \>75 is a contraindication for LT). * Written informed consent. Exclusion Criteria: * Exclusion criteria for MRI (claustrophobia, pacemaker, metal implants, etc.). * A psychiatric, addictive or any other disorder that compromises the subjects ability to understand the study content and to give written informed consent for participation in the study.
Where this trial is running
Leiden, South Holland
- Leiden University Medical Center — Leiden, South Holland, Netherlands (Recruiting)
Study contacts
- Principal investigator: Hildo J Lamb, PhD, MD — Leiden University Medical Center
- Study coordinator: Hildo J Lamb, PhD, MD
- Email: h.j.lamb@lumc.nl
- Phone: 715269111
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.