Non-invasive method to estimate portal and hepatic vein pressure

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study aims to develop a non-invasive technique for estimating portal and hepatic vein pressure using advanced magnetic resonance imaging (MRI) methods. By employing four-dimensional flow MRI, the researchers seek to improve the accuracy of diagnosing portal hypertension, a serious complication of liver disease. The approach focuses on visualizing abdominal blood flow circulation and quantifying pressure gradients without the need for invasive procedures. This could lead to better prognostic and therapeutic strategies for patients with end-stage liver disease.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Eligible for liver transplantation (LT) screening (which excludes pregnancy).
* Age ≥ 18 years and ≤ 75 (since \>75 is a contraindication for LT).
* Written informed consent.

Exclusion Criteria:

* Exclusion criteria for MRI (claustrophobia, pacemaker, metal implants, etc.).
* A psychiatric, addictive or any other disorder that compromises the subjects ability to understand the study content and to give written informed consent for participation in the study.

Where it's running

• Leiden University Medical Center
  Leiden, South Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Hildo J Lamb, PhD, MD — Leiden University Medical Center
• Study coordinator: Hildo J Lamb, PhD, MD
• Email: h.j.lamb@lumc.nl
• Phone: 715269111

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.