Using imaging to improve proton therapy for chordomas and chondrosarcomas

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This study focuses on patients with chordomas and chondrosarcomas located in the axial skeleton, which are aggressive bone tumors. It aims to optimize proton radiation therapy by utilizing advanced imaging techniques, such as MRI and PET-CT, to identify viable tumor components. The study will include patients who are histologically diagnosed with these tumors and are accepted for standard proton beam therapy. The goal is to enhance treatment outcomes by better targeting the tumor while minimizing damage to surrounding critical structures.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Histologically diagnosed with primary or recurrent chordoma or chondrosarcoma in the axial skeleton (clivus, spine and sacrum)
* Accepted for standard proton beam therapy

Exclusion Criteria:

* Diagnosis other than chordoma or chondrosarcoma is made.
* Patient refuses (parts) of the standard treatment protocol.
* Patient refuses MRI due to claustrophobia.
* Patient not suitable for MRI due to the presence of MRI incompatible implants.
* Incapacitated patients.
* Patient doesn't allow coded data to be used for analysis.
* Patient is under 50 years of age.
* Lesion size less than 1cm.
* Patients with WHO 3 and higher.

Where it's running

• HollandPTC
  Delft, South Holland, Netherlands Recruiting
• Lumc
  Leiden, South Holland, Netherlands Recruiting

Study contacts

• Principal investigator: Stijn Krol, MD PhD — LUMC/HollandPTC
• Study coordinator: Stijn Krol, dr. PhD
• Email: A.D.G.Krol@lumc.nl
• Phone: +31624539398

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Other studies for the same condition or treatment. Recruiting studies are listed first.

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.