Predicting success of epidural injections for sciatica treatment

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to develop a predictive model for treatment success following transforaminal epidural injections (TEI) in patients with lumbar radiculopathy due to lumbar disc herniation or spinal stenosis. It will collect demographic, clinical, and radiological data to identify factors that correlate with positive treatment outcomes. Additionally, the study will assess the short-term efficacy of TEI based on pain relief, functionality, and patient-reported recovery scores, as well as the rates of subsequent treatments and surgeries. The findings could help tailor treatment plans for better patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Diagnosis of unilateral lumbar radiculopathy secondary to LDH or one-level spinal stenosis
* Diagnosis supported by magnetic resonance imaging (MRI) findings
* Scheduled appointment for TEI
* Access to e-mail
* Signed informed consent

Exclusion Criteria:

* Diagnosis of unilateral lumbar radiculopathy secondary to LDH or one-level spinal stenosis
* Age under 18 years
* Severe multisegmental spinal disease
* Anatomical abnormalities that may complicate the procedure technically (e.g. severe scoliosis)
* Active malignancy or infectious disease
* Use of immunosuppressive drugs
* Use of systemic corticosteroids in preceding 3 months
* Previous treatment with TEI for current episode of lumbar radiculopathy
* History of lower back surgery at the same lumbar level
* Circumstances that prevent treatment with TEI (e.g. use of anticoagulants that cannot be temporarily discontinued, allergy against steroids or local anaesthetic)
* Pregnancy
* Major language barrier

Where it's running

• Spaarne Gasthuis
  Haarlem, Netherlands Recruiting

Study contacts

• Principal investigator: Carmen LA Vleggeert-Lankamp, MD, PhD — Leiden University Medical Centre / Spaarne Gasthuis
• Study coordinator: Eduard JA Verheijen, MD
• Email: e.j.a.verheijen@lumc.nl
• Phone: +3171526746

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

• Using regional anesthesia to reduce opioid use in spine surgery

  This study is testing if a special pain management technique can help people having spine surgery use less opioid medication after their operation.

  Recruiting Phase 4 Rush University Medical Center · Chicago, Illinois · NCT05029726

• Effect of Irrigation Pressure on Postoperative Complications and Surgical Field Clarity in Unilateral Biportal Endoscopic Spine Surgery

  This study tests whether the height of the irrigation fluid bag and the direction of the surgical cut affect fluid pressure, visibility, and early recovery in adults undergoing unilateral biportal endoscopic spine surgery.

  Recruiting First Affiliated Hospital of Kunming Medical University · Kunming, Yunnan · NCT07837427

• High-Intensity Laser Therapy vs Epidural Injection for Chronic Lumbar Disc Herniation Pain

  This trial tests whether high-intensity laser therapy can relieve chronic low back and leg pain as well as a transforaminal epidural steroid injection in adults with lumbar disc herniation.

  Recruiting Ankara City Hospital Bilkent · Ankara · NCT07688915

• Impact of muscle degeneration on chronic low back pain after surgery

  This study looks at how muscle loss affects ongoing back pain in people who have surgery for spine problems, to help improve recovery and predict results.

  Recruiting Hospital Israelita Albert Einstein · São Paulo, São Paulo · NCT04273828

• Mulligan leg raise vs spinal mobilization with leg movement for lumbar radiculopathy

  This trial tests whether Mulligan leg raise traction or spinal mobilization with leg movement helps people with lumbar radiculopathy feel better.

  Recruiting Foundation University Islamabad · Islamabad, Punjab Province · NCT07887685

• Prone lumbar disc surgery: how breathing and brain oxygen relate

  This study will observe whether changes in breathing mechanics during prone lumbar disc surgery relate to brain oxygen levels in adults.

  Recruiting Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital · Istanbul, Istanbul · NCT07862257

How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.