Personalized cancer treatment using an integrated decision-making approach
Official title: Improving Personalized Treatment in Oncology: Effects of Integrated Oncological Decision-making
Run by Leiden University Medical Center · NCT07046884 · Data updated 2026-11-12
This study tests an Integrated Oncological Decision-making Model to see if combining treatment options, a patient's overall health, and their personal goals helps adults with cancer get more personalized treatment decisions.
Quick facts
| Study type | Interventional |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 400 (estimated) |
| Sponsor | Leiden University Medical Center Academic / other |
| Locations | 4 sites (Groningen and 3 other locations) |
| Status | Recruiting |
| Started | March 25, 2024 |
| Main results expected | March 2026 |
| Study ends | March 2026 |
| Registry record updated | July 2, 2025 |
| Trial ID | NCT07046884 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) who are enrolled in one of the participating oncological care paths, do not yet have a treatment plan, can read and speak Dutch, and are able to participate in the decision-making process.
✕Probably not a fit
Patients who already have a finalized treatment plan, cannot give informed consent, or cannot read/speak Dutch or participate in decision-making are unlikely to benefit from this intervention.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
The trial uses a stepped-wedge cluster randomized design across eight oncological care paths in four Dutch medical centers, enrolling about 400 adult patients. Care paths will transition from usual guideline-based decision-making to the Integrated Oncological Decision-making Model (IODM) in randomized steps so all clusters eventually use the IODM. The intervention integrates three elements—available oncological treatment options, the patient’s general health status, and the patient's goals and preferences—into local care processes. Primary measures include the discordance between guideline-based recommendations and final treatment decisions and whether such discordance reflects more personalized decision-making, alongside a detailed process evaluation of implementation.
Why it matters
Potential benefit: If successful, the IODM could produce treatment plans that better match patients' health and personal goals, improving the personalization of care and potentially patient satisfaction and outcomes.
How similar studies have gone: Shared decision-making and personalization approaches have shown benefits in other oncology settings, but applying the specific IODM across multiple care paths with a stepped-wedge implementation is relatively novel.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Patient's age = 18+ * Patient is included in participating oncological care path * Patient does not yet have a treatment plan * Patient, partner, or caregiver who reads and speaks Dutch sufficiently to understand the research material and to complete the questionnaires * Patient must be able to participate in the decision-making process Exclusion Criteria: • Patient, partner, or caregiver cannot give informed consent
Where it's running
-
University Medical Center Groningen (UMCG)
Groningen, Netherlands Recruiting -
Leiden University Medical Center (LUMC)
Leiden, Netherlands Recruiting -
Maastricht University Medical Center
Maastricht, Netherlands Recruiting -
Zuyderland MC
Sittard, Netherlands Recruiting
Study contacts
- Principal investigator: Lieke Welling, MD PhD (Dr) — Department of Surgery
- Study coordinator: Lieke Welling, MD PhD (Dr)
- Email: L.welling@lumc.nl
- Phone: +31647140968
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.