Low-Field MRI in Emergency Stroke Care
Official title: Validation of Low Field MRI in Patients With Stroke Symptoms Less Than 12 Hours
Run by Leiden University Medical Center · NCT07702968 · Data updated 2026-11-12
This study tests whether a portable low-field MRI can help detect acute stroke in patients arriving with suspected stroke.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 80 (estimated) |
| Sponsor | Leiden University Medical Center Academic / other |
| Locations | 1 site (Leiden, South Holland) |
| Status | Recruiting |
| Started | April 20, 2026 |
| Main results expected | April 1, 2027 |
| Study ends | August 1, 2027 |
| Registry record updated | July 16, 2026 |
| Trial ID | NCT07702968 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults (18+) with suspected acute stroke presenting to LUMC within 12 hours of symptom onset and undergoing standard head CT.
✕Probably not a fit
Patients with conditions that prevent MRI or where MRI would not change management may not benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
In this observational study, adult patients with suspected acute stroke who are getting standard CT exams will also receive a portable low-field MRI (Hyperfine). The scans will be compared to the routine CT results and the final clinical diagnosis to see if the low-field MRI reliably detects ischemic stroke, hemorrhagic stroke, or stroke mimics. Secondary outcomes include scan time, completion rate, patient satisfaction, and any adverse events. The study takes place at Leiden University Medical Center and includes only patients presenting within 12 hours of symptom onset and who can provide informed consent.
Why it matters
Potential benefit: If successful, portable low-field MRI could provide rapid additional imaging at the bedside, potentially speeding diagnosis and treatment decisions.
How similar studies have gone: Previous work with low-field MRI in acute settings shows feasibility and potential for stroke detection, but results vary and further validation is needed.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Age ≥ 18 years * Presentation with suspected acute stroke (stroke code activation by ambulance paramedics) * Symptom onset \< 12 hours prior to presentation * Admission to the emergency department of the Leiden University Medical Center (LUMC) during office hours * Undergoing standard-of-care head CT imaging at the emergency department * Ability to provide informed consent (written or verbal in the acute setting, with deferred written consent if applicable) Exclusion Criteria: * Imminent death * Severe claustrophobia preventing MRI * Presence of MRI-incompatible implanted devices (e.g., pacemaker, cochlear implant, insulin pump) * Known intra-ocular metallic foreign body or intracranial metallic clip/device identified on admission CT * Pregnancy * Acute life-threatening or disabling condition requiring immediate intervention that precludes study procedures * Any study-related delay that could interfere with time-critical stroke treatments (intravenous thrombolysis or endovascular thrombectomy)
Where it's running
-
Leiden University Medical Center
Leiden, South Holland, Netherlands Recruiting
Study contacts
- Study coordinator: Nyika Kruyt, MD, PhD
- Email: n.d.kruyt@lumc.nl
- Phone: +31 71 526 9111
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.