Comparing two antibiotic combinations for treating complicated MRSA carriage

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This multicenter open-label cluster randomized controlled trial aims to determine whether doxycycline-rifampicin is more effective than trimethoprim-rifampicin for decolonizing patients with complicated MRSA carriage. The study will involve adult patients who meet specific criteria for complicated MRSA carriage and will compare the success rates of the two antibiotic regimens over a 7-day treatment period. The trial is designed to provide robust evidence to guide treatment recommendations for MRSA decolonization.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age ≥18 years
* Complicated MRSA carriership. Complicated carriership is defined as having one of the following features: (i) the presence of MRSA located at another site than the nose, (ii) an active infection with MRSA, (iii) in vitro resistance for mupirocin, (iv) active skin lesions, (v) foreign material that connects an internal body site with the outside (e.g., urine catheter, external fixation material), (vi) previously failure of decolonization treatment.

In case of none of the previously mentioned features, this is considered uncomplicated carriership.

\- The ability to provide informed consent for the use of their data.

Exclusion Criteria:

* \- Presence of any iv-access, urinary catheters or drains (because of high risk of treatment failure)
* Failure of previous decolonization attempt of complicated MRSA carriage
* Allergy or other contra-indication to either doxycycline, rifampicin or trimethoprim (these patients will participate in the observational arm)
* Previous participation in this study (every patient can only participate once)
* Pregnancy

Where it's running

• Lumc
  Leiden, Netherlands Recruiting

Study contacts

• Principal investigator: Merel Lambregts, MD PhD — Leiden University Medical Center
• Study coordinator: Annette Westgeest, MD
• Email: a.c.westgeest@lumc.nl
• Phone: +3171 5262613

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.