Neural Circuitry Resilience in Psychotic Disorders
Official title: Neural Circuitry Resilience in Psychotic Disorders: A Multimodal Ultra-High Field Neuroimaging Study
Funded at Veterans Health Administration · NIH-11563768 · Data updated 2026-11-12
Researchers are using ultra-high-field brain scans to understand how brain networks in people with schizophrenia adapt over time, with the goal of finding new ways to improve thinking and daily functioning.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2027 |
| Funding year | 2027 |
| NIH project number | 5I01CX001855-06 |
| Project ID | NIH-11563768 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with schizophrenia and healthy controls who can undergo 7 Tesla MRI and related assessments.
✕Less likely to help
Individuals unable to have high-field MRI or who do not fit the study’s imaging requirements may not benefit from participation.
What this research studies
This project will compare brain connections and the tissue environment in people with schizophrenia to healthy individuals using advanced 7 Tesla MRI and phosphorus spectroscopy. By examining how cortical networks and white matter change together, it aims to identify mechanisms that support cognitive performance. The study will look for patterns of neural adaptation that correlate with better or worse cognitive outcomes, which could guide future treatments. Participants may undergo high-resolution imaging and related assessments to map brain structure and function. The work is designed to inform new strategies to help people living with schizophrenia improve long-term outcomes.
Why it matters
Potential benefit: In the best case, findings could lead to new brain-based targets for therapies that improve cognition and daily functioning in schizophrenia.
How similar studies have gone: Previous studies using advanced neuroimaging have shown that brain networks can adapt in schizophrenia, supporting potential for new interventions.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Prasad, Konasale M — Veterans Health Administration
- Study coordinator: Prasad, Konasale M
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.