Condition

Aggression clinical trials and research

• 15Clinical trials
• 51NIH research projects
• 9Countries

Newest Aggression clinical trials

All recruiting trials (15)

• Just-in-Time Coping Prompts for College Students

  We’re testing whether sending brief coping tips at moments of emotional shift can influence how college students react online, drink, or eat when feelings spike.

  Recruiting University of Florida · Gainesville, Florida · NCT07789314

• Momentary Coping Prompts and Hair Steroids in College Students

  This trial tests whether sending brief coping prompts at moments of emotional volatility helps college students respond to emotions, while collecting hair samples to see if long-term stress hormones relate to those responses.

  Recruiting University of Florida · Gainesville, Florida · NCT07782398

• Virtual reality program to reduce aggression in young offenders

  This program will test whether adding virtual reality to a four-session intervention helps reduce aggressive behavior in 12–18-year-old juvenile offenders more than the same intervention without VR or their usual treatment.

  Recruiting Universidad Francisco de Vitoria · Pozuelo de Alarcón, Cominity of Madrid · NCT07484919

• Virtual reality mindfulness for reducing aggression in schizophrenia

  We will test whether a virtual reality mindfulness program can help people with schizophrenia or schizoaffective disorder reduce impulsive aggression.

  Recruiting at 2 sites Manhattan Psychiatric Center · New York, New York and 1 other locations · NCT07434479

• Propranolol for aggression, self-injury, and severe disruptive behaviors in adolescents and adults with autism

  This trial will test whether propranolol can reduce aggression, self-injury, and other severe disruptive behaviors in people with autism aged 12 to 40.

  Recruiting at 2 sites Phase 2 New York State Psychiatric Institute · Staten Island, New York and 1 other locations · NCT07091279

• Step-by-Step: Stepped care for children with defiant or aggressive behavior

  This project tests a stepped care program for families of 8–16-year-olds with defiant or aggressive behavior, starting with an online parenting course and adding virtual-reality–assisted CBT for the child or parent or usual clinic care if more help is needed.

  Recruiting Karolinska Institutet · Solna · NCT06902649

• Treatment for anger and aggression in military personnel after betrayal

  This study tests a new treatment program to help active duty service members and veterans manage anger and aggression caused by feelings of betrayal in the military.

  Recruiting The University of Texas Health Science Center at San Antonio · Fort Cavazos, Texas · NCT06609330

• Effects of Cool Roofs on Health and Indoor Environments

  This study is testing if special cool roofs that reflect sunlight can help people living in hot urban areas feel better and stay healthier by reducing heat exposure.

  Recruiting University of Auckland, New Zealand · Ouagadougou and 4 other locations · NCT06579950

• Assessment and treatment model for challenging behavior in children

  This study is testing a new guide to help kids aged 3 to 17 with challenging behaviors, like aggression and self-injury, to see if it can improve their treatment and support.

  Recruiting Rutgers, The State University of New Jersey · Somerset, New Jersey · NCT05928247

• Evaluating the effects of extinction bursts in children with problem behaviors

  This study tests how different ways of rewarding kids aged 3 to 17 with problem behaviors can help reduce the increase in bad behavior that sometimes happens when treatment starts.

  Recruiting Rutgers, The State University of New Jersey · Somerset, New Jersey · NCT05925101

• Program to prevent youth gun violence in Washington D.C.

  This study is testing a summer job program in Washington D.C. to see if it helps young people change their behavior and attitudes about gun violence.

  Recruiting University of Michigan · Ann Arbor, Michigan · NCT05887973

• Evaluating a new approach to reduce problem behaviors in children

  This study is testing a new way to help children aged 3 to 17 with serious problem behaviors, like aggression and self-injury, by alternating between sessions where they get what they want and sessions where they don’t, to see if it helps reduce those behaviors.

  Recruiting Rutgers, The State University of New Jersey · Somerset, New Jersey · NCT05537610

• Using brain stimulation to reduce aggression in adults with developmental disabilities

  This study is testing if a brain stimulation technique can help reduce impulsivity and aggression in adults with developmental disabilities.

  Recruiting Queen's University · Kingston, Ontario · NCT04732052

• Cognitive training for improving mental health in forensic patients

  This study is testing if a special brain training program can help improve thinking skills and mental health for people in a secure facility.

  Recruiting The Royal Ottawa Mental Health Centre · Ottawa, Ontario · NCT04610697

• Improving Functional Communication Training for Children with Problem Behaviors

  This study is testing new ways to improve communication training for children with aggressive or self-harming behaviors to see if it helps them behave better in different situations.

  Recruiting Rutgers, The State University of New Jersey · Somerset, New Jersey · NCT04045600

NIH-funded research (newest 40 of 51)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• How sex differences affect the rewarding feel of aggression in the brain

  This grant explores why aggressive experiences feel more rewarding in females and how specific brain circuits and chemical signals shape this in both sexes.

  NIH research Pennsylvania State University, the · University Park, United States · NIH-11515869

• Metabolic therapy to reduce aggression and improve sociability in Alzheimer’s disease models

  A ketogenic diet and adenosine biology are explored to see if they can lessen aggression and improve social behavior in models related to Alzheimer’s disease.

  NIH research Trinity College · Hartford, United States · NIH-11444976

• Genomic keys to juvenile aggression in kids and animals

  A study using a novel animal model to uncover genomic factors that influence violent aggression in young individuals, with potential insights for understanding and preventing harmful behavior.

  NIH research University of California at Davis · Davis, United States · NIH-11380064

• Men's drinking and sexual risk behaviors: alcohol, aggression, and emotions

  A study with 21–30 year old men who drink and have condom-use challenges will look at how alcohol, aggression history, and emotions relate to risky sexual behavior.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11378982

• Sex differences in brain circuits that control aggression

  This project looks at how brain networks that drive aggressive behavior may differ between sexes, with the goal of understanding why aggression patterns differ and how they might be treated.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11378527

• Understanding how genes and environment influence aggressive behavior in teens and young adults

  A study looks at how genetic factors and experiences during childhood interact to shape aggressive behavior in adolescents and young adults, with potential implications for better treatments.

  NIH research University of Florida · Gainesville, United States · NIH-11375728

• Neural markers that predict how kids with ADHD respond to CNS stimulants

  This project looks at brain signals to see if they can predict which children with ADHD and aggression will benefit from stimulant medications.

  NIH research Pennsylvania State Univ Hershey Med Ctr · Hershey, United States · NIH-11370254

• Virtual reality mindfulness to reduce aggression in schizophrenia

  A VR mindfulness program is being tested to help reduce aggressive outbursts in people with schizophrenia.

  NIH research Nathan S. Kline Institute for Psych Res · Orangeburg, United States · NIH-11369803

• Epigenetic control of aggression study in fruit flies

  Researchers are studying how epigenetic changes influence aggressive behavior in fruit flies to uncover basic biology that could inform human aggression understanding.

  NIH research Baylor College of Medicine · Houston, United States · NIH-11368257

• How childhood trauma can change brain connections and lead to impulsive aggression

  This project looks at whether changes in a specific brain circuit after early-life trauma cause attention problems and impulsive aggression in people who experienced childhood abuse or neglect.

  NIH research Virginia Polytechnic Inst and St Univ · Blacksburg, United States · NIH-11360714

• Long-term study on how threat exposure links to emotional reactions and self-harm thoughts in youth

  This project follows young people to understand how scary or threatening experiences might shape emotional responses and the risk of self-injury thoughts or behaviors over time.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11360221

• How stress changes the amygdala to increase aggression

  This project looks at how stress alters specific amygdala brain cells that can drive aggressive behavior, aiming to help people who develop anger or PTSD after trauma.

  NIH research Tufts University Boston · Boston, United States · NIH-11332982

• Seasonal switch in brain chemicals that control aggression

  A new NIH grant looks at how seasonal changes in hormones influence aggressive behavior and could help people with mood and anxiety disorders that involve aggression.

  NIH research Trustees of Indiana University · Bloomington, United States · NIH-11332581

• Integrated treatment for alcohol use and aggressive behavior

  This project tests a combined therapy to help people who drink heavily and also struggle with anger or aggressive behavior.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11324548

• Moderators and mediators of within-person risk for sexual aggression in college men

  This grant tests how daily alcohol use, arousal, and protective strategies relate to sexually aggressive behavior in college men, to inform better prevention.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11319688

• Does short-term inflammation increase anger and aggression?

  Researchers will give a mild, short-lived immune challenge to people with and without histories of aggression to find out if inflammation makes anger and aggressive behavior worse.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11309150

• Brain circuits that control aggression

  Researchers are mapping brain cells and circuits in mice that decide when and toward whom aggression is directed to help explain misdirected aggression seen in conditions like bipolar disorder.

  NIH research New York University School of Medicine · New York, United States · NIH-11285324

• How the front part of the brain controls aggression caused by social isolation

  This project looks at how specific brain cells in the front of the brain may cause aggressive behavior after long periods of social isolation, aiming to inform future ways to help people affected by loneliness-related aggression.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11283990

• Investigating how stress affects aggression in the brain

  This study is looking at how certain brain cells might make people more aggressive after they've experienced trauma, and it hopes to find new ways to help those who struggle with this issue.

  NIH research Tufts University Boston · Boston, United States · NIH-11269353

• Exploring how inflammation affects human aggression

  This study is looking at how inflammation in the body might affect how we act and feel, especially when it comes to aggressive behavior, and it's for anyone interested in understanding more about what drives aggression and its causes.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11233543

• How early life stress affects aggression through brain circuitry

  This study is looking at how tough experiences in childhood, like feeling alone or going through trauma, can affect the brain and lead to aggressive behavior in adults, with the hope of finding better ways to help people manage their anger.

  NIH research Southern Illinois University Carbondale · Carbondale, United States · NIH-11178837

• How couples' social networks relate to alcohol-related partner aggression in low-income communities

  This project looks at whether couples' in-person and online social connections change the link between drinking and partner aggression for couples from low-income communities.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11170509

• Understanding the genetic factors behind aggressive behavior in children

  This study is looking at what causes aggressive behavior in kids by using a special type of frog that shows a lot of aggression, and it aims to help us understand how both genes and the environment play a role in this behavior and its effects on everyone involved.

  NIH research University of California at Davis · Davis, United States · NIH-11167278

• Understanding how alcohol, aggression, and feelings affect sexual health choices in men

  This project explores how alcohol, past aggressive actions, and emotions influence young men's decisions about safe sex, aiming to help prevent risky behaviors.

  NIH research Arizona State University-Tempe Campus · Scottsdale, United States · NIH-11146524

• Understanding why young children might hurt themselves

  This project looks at how stressful experiences and strong emotions in young children connect to thoughts and actions of self-harm.

  NIH research Research Triangle Institute · Research Triangle Park, United States · NIH-11145811

• Understanding Aggression in the Brain

  This research aims to uncover how brain circuits contribute to aggressive behaviors, hoping to find new ways to help people struggling with aggression.

  NIH research Icahn School of Medicine at Mount Sinai · New York, United States · NIH-11140982

• How inflammation affects aggression in humans

  This study is looking at how inflammation might affect feelings of anger and aggressive behavior in people, especially those with mood or anxiety issues, by giving some participants a substance that causes inflammation and comparing their reactions to those who receive a harmless placebo.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11136950

• Understanding the genetics behind aggression in fish

  This study looks at how genetic differences affect aggressive behavior by using blind Mexican cavefish, and it aims to find out which genes are linked to aggression, which could help us understand similar traits in other animals, including people.

  NIH research Lehigh University · Bethlehem, United States · NIH-11135763

• Understanding how seasonal changes affect aggression in humans

  This study is looking at how the hormone melatonin affects aggressive behavior and how it interacts with other hormones, hoping to find new ways to help people with conditions like ADHD, autism, and mood disorders.

  NIH research Trustees of Indiana University · Bloomington, United States · NIH-11108521

• Understanding how aggressive behavior affects suicide risk in veterans

  This study is looking at how reacting aggressively when provoked might be connected to thoughts and actions related to suicide in veterans who are at higher risk, with the goal of finding better ways to help and support them.

  NIH research Olin Teague Veterans Center · Temple, United States · NIH-11072056

• Creating a new treatment for alcohol use disorder and aggression

  This study is testing a new program to help people who have trouble with alcohol and also struggle with anger, using friendly techniques to reduce both drinking and aggressive behavior.

  NIH research Temple Univ of the Commonwealth · Philadelphia, United States · NIH-11051885

• Creating personalized models to predict aggressive behavior

  This study is looking to understand what causes aggressive behavior in young adults by using smartphones to collect real-time information about their daily lives, and it aims to create personalized tools that could help prevent such behavior in the future.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11051796

• How observing aggression affects behavior in children

  This study looks at how kids might learn to be aggressive by watching others, using mice to understand how their brains work when they see someone being aggressive, and it hopes to find ways to help prevent aggressive behavior in children who witness violence.

  NIH research Southern Illinois University Carbondale · Carbondale, United States · NIH-11051313

• Understanding how brain activity influences social aggression

  This study is looking at how brain cells work together when it comes to social aggression, using special technology to see and change brain activity in real-time, and it hopes to find new ways to help people with aggression-related issues.

  NIH research Duke University · Durham, United States · NIH-11044099

• Understanding how the brain controls aggression

  This study is looking at how certain experiences can change the brain and lead to ongoing aggressive behavior, which could help us understand why some people with conditions like autism and bipolar disorder struggle with aggression.

  NIH research Princeton University · Princeton, UNITED STATES · NIH-11020966

• How gut bacteria affect sleep and aggression in blind cavefish

  This study is looking at how the tiny bacteria in the guts of blind Mexican cavefish might affect their sleep and aggression, and it could help us understand how gut health relates to behavior in people too!

  NIH research University of Puerto Rico Med Sciences · San Juan, United States · NIH-11019162

• Understanding how social isolation affects aggression in the brain

  This study looks at how being socially isolated can lead to increased aggression and aims to understand how a specific part of the brain helps control this behavior, especially for older adults who may be feeling lonely.

  NIH research University of Utah · Salt Lake City, United States · NIH-11010824

• Understanding how sex differences affect aggression and its rewards

  This study is looking at how the brain works differently in men and women when it comes to aggression, especially how certain brain areas respond to aggressive experiences and how a hormone called oxytocin might play a role in this, with the hope of finding better treatments for people dealing with aggression-related m

  NIH research University of Minnesota · Minneapolis, United States · NIH-10993652

• Preventing peer aggression and dating violence in preteens with mental health challenges

  This study is testing a supportive program designed to help preteens aged 11 to 13, who have faced tough experiences and are getting mental health help, learn how to handle conflicts better and build healthier friendships, all while reducing bullying and dating violence.

  NIH research Rhode Island Hospital · Providence, United States · NIH-10992953

• How social networks and alcohol use affect aggression in couples from low-income communities

  This study is looking at how drinking alcohol and social connections can affect arguments and aggression between partners in low-income communities, and it’s for couples who want to understand how their friendships and social circles might play a role in their relationship dynamics.

  NIH research Arizona State University-Tempe Campus · Tempe, United States · NIH-10950581

Related topics

Quick answers

How many Aggression clinical trials are recruiting right now?

15, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 9 countries. The most sites are in United States (10 trials), Canada (2 trials), Spain (1 trial), Burkina Faso (1 trial), Fiji (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

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