Understanding how brain circuits adapt in people with psychotic disorders
Official title: Neural Circuitry Resilience in Psychotic Disorders: A Multimodal Ultra-High Field Neuroimaging Study
Funded at Veterans Health Administration · NIH-10980516 · Data updated 2026-11-12
This study is looking at how the brains of people with schizophrenia change and adapt, especially in relation to thinking skills, to find new ways to help improve those skills.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project start | October 1, 2021 |
| Project end | September 30, 2026 |
| Funding year | 2025 |
| NIH project number | 5I01CX001855-04 |
| Project ID | NIH-10980516 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with schizophrenia who experience cognitive impairments.
✕Less likely to help
Patients with psychotic disorders other than schizophrenia or those without cognitive impairments may not benefit from this research.
What this research studies
This research investigates the brain's ability to adapt in individuals with schizophrenia, focusing on how changes in brain structure and connectivity relate to cognitive performance. Using advanced neuroimaging techniques, including ultra-high field magnetic resonance spectroscopy, the study aims to explore the relationship between brain circuitry and cognitive impairments that are often resistant to treatment. By comparing individuals with schizophrenia to healthy controls, the research seeks to identify potential targets for new therapeutic interventions that could improve cognitive outcomes.
Why it matters
Potential benefit: If successful, this research could lead to new treatment strategies that enhance cognitive function in individuals with schizophrenia.
How similar studies have gone: Previous research has shown promising results in understanding brain adaptability in various neurological conditions, suggesting potential for success in this novel approach.
Where this research is happening
-
Veterans Health Administration
Pittsburgh, United States Active
Researchers
- Principal investigator: Prasad, Konasale M — Veterans Health Administration
- Study coordinator: Prasad, Konasale M
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Neural Circuitry Resilience in Psychotic Disorders
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.