Condition

Aneurysm clinical trials and research

• 13Clinical trials
• 103NIH research projects
• 14Countries

Newest Aneurysm clinical trials

All recruiting trials (13)

• Individual patient data analysis of Gore Iliac Branched Endoprosthesis patients

  This project tests how well the Gore Iliac Branched Endoprosthesis works by pooling detailed patient data from published studies to see patterns in outcomes.

  Recruiting Rijnstate Hospital · Arnhem, Gelderland · NCT07704671

• Endovascular repair of intracranial aneurysms with the Surpass Elite plus GUARDian flow diverter

  This trial tests whether the Surpass Elite with GUARDian flow diverter safely and effectively treats unruptured wide‑neck saccular or fusiform aneurysms on the internal carotid artery or its branches in adults.

  Recruiting at 20 sites Stryker Neurovascular · Tucson, Arizona and 19 other locations · NCT06872684

• Pipeline Flex with Shield flow-diverter for wide‑neck intracranial aneurysms

  The Pipeline Flex Embolization Device with Shield Technology will be tested in adults 22 and older who have wide‑necked intracranial aneurysms in specified parts of the internal carotid artery.

  Recruiting Jacobs institute · Buffalo, New York · NCT06793059

• Collection of data and samples linked to the French Register of Intracranial Aneurysms

  This study is trying to gather information and samples to help understand different types of brain aneurysms and see if genetics can help predict their risk of bursting.

  Recruiting at 10 sites Nantes University Hospital · Nantes, Loire-Atlantique and 25 other locations · NCT06689410

• Assessing postoperative recovery and adverse events in neurosurgery using a smartphone app

  This study is testing a smartphone app to see how well it can track recovery and any problems after brain surgery for patients.

  Recruiting Cantonal Hospital of St. Gallen · Sankt Gallen, St.Gallen · NCT06352710

• Study of aortic arch anatomical variations

  This study looks at the different shapes of the aortic arch in people with and without aneurysms to see how a common variation might relate to heart problems.

  Recruiting IRCCS San Raffaele · Milan, Italy · NCT06235619

• Using whole-body MRI to identify significant health issues in the general population

  This study is testing if whole-body MRI scans can help find serious health problems like cancer and heart issues in people aged 18 and older.

  Recruiting Hercules · Watertown, Massachusetts · NCT06212479

• Follow-up on the Lifetech Cera Vascular Plug System

  This study is looking to see how well the Lifetech Cera Vascular Plug System works and if it’s safe for people who need treatment for blood vessel issues.

  Recruiting at 9 sites Lifetech Scientific (Shenzhen) Co., Ltd. · Bad Hersfeld and 8 other locations · NCT06099015

• Global registry for treating wide neck intracranial aneurysms with the SEAL™ System

  This study is testing the SEAL™ System to see if it safely helps people with wide neck brain aneurysms, whether they are new or have burst, and will track their recovery over five years.

  Recruiting at 4 sites Galaxy Therapeutics INC · Itagüi, Medellín and 3 other locations · NCT05880680

• Combining tocilizumab and tofacitinib for treating vascular Behçet's syndrome

  This study is testing if combining two newer medications, tocilizumab and tofacitinib, with steroids can help people with vascular Behçet's syndrome feel better compared to the usual treatment.

  Recruiting Phase 2 Peking Union Medical College Hospital · Beijing, Beijing Municipality · NCT05845723

• Registry collecting data on Terumo Aortic grafts and patches

  This study is collecting information on the safety and effectiveness of Terumo Aortic grafts and patches used in heart procedures to help improve patient care.

  Recruiting at 26 sites Vascutek Ltd. · Aurora, Colorado and 29 other locations · NCT04545502

• Long-term follow-up for patients after brain aneurysm embolization

  This study is tracking over 2,000 patients who had brain aneurysms treated to see how well the treatment works over time and if they need any more procedures.

  Recruiting Fondation Ophtalmologique Adolphe de Rothschild · Paris · NCT02878967

• Infliximab treatment for dolichoectatic vertebrobasilar aneurysms

  This trial will test whether infliximab, a TNFα blocker, can slow aneurysm growth or reduce complications in adults with dolichoectatic vertebrobasilar aneurysms who are not candidates for surgery.

  Recruiting Phase 1/2 University of California, San Francisco · San Francisco, California · NCT02638701

NIH-funded research (newest 40 of 103)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• WARRIORS: Should women with small abdominal aortic aneurysms get early repair or stay under surveillance?

  A large international study is testing whether women with small abdominal aortic aneurysms should have early repair or watchful waiting, to see if earlier treatment improves survival and quality of life.

  NIH research Stanford University · Stanford, United States · NIH-11599311

• Biomarker clues from animal and computer models to predict when the ascending aorta could fail

  Researchers will combine animal studies and computer models to find biological clues that help predict dangerous changes in the ascending aorta for people with aortic aneurysm.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11465647

• How the small regulator miR-146a affects abdominal aortic aneurysm

  This project aims to see if boosting a natural genetic regulator called miR-146a can help slow or prevent growth and rupture of abdominal aortic aneurysms in people with this condition.

  NIH research University of Nebraska Medical Center · Omaha, United States · NIH-11453518

• MOF’s role in weakening the aorta and stopping aneurysm growth

  Scientists are studying how a molecule called MOF and inflammatory signals affect abdominal aortic aneurysms to find ways to slow or stop their enlargement.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11424572

• WARRIORS: Early repair or observation for women with small abdominal aortic aneurysms

  This research test asks whether women with small, asymptomatic abdominal aortic aneurysms should have early repair or continued surveillance to improve survival and quality of life.

  NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11415182

• Endovascular Suturing Device to Improve Endograft Fixation in Abdominal Aortic Aneurysm

  A new device aims to better secure endografts during EVAR for abdominal aortic aneurysm to reduce future repairs.

  NIH research Vesteck, INC · Malvern, UNITED STATES · NIH-11414951

• Sexual differences in thoracic aortic aneurysm biology

  A study to understand why men and women experience thoracic aortic aneurysms differently, with a focus on human tissue and biology.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11406202

• Understanding how brain aneurysm walls and shape change over time

  This project studies how small brain aneurysms grow and whether MRI features of the aneurysm wall and its shape can predict growth so doctors can better decide when treatment is needed.

  NIH research University of Washington · Seattle, United States · NIH-11396260

• Triglyceride-rich lipoproteins and abdominal aortic aneurysm growth

  A study exploring how fats in the blood (TRLs) influence the growth of abdominal aortic aneurysms to find non-surgical ways to protect against rupture, especially in people aged 65 and older.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11389655

• Computational modeling of platelets and blood flow to predict cerebral aneurysm treatment outcomes

  A researchers at UW are using computer models of blood flow and platelets to better predict whether an aneurysm treatment will work.

  NIH research University of Washington · Seattle, United States · NIH-11385494

• Using genetics to uncover how abdominal aortic aneurysms develop

  A research team will study how genetic differences influence abdominal aortic aneurysm to help with earlier prevention and better treatment.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11382092

• Phospholipid-based nanotherapies to treat abdominal aortic aneurysm

  A new nanoparticle treatment is being developed to slow or stop the growth of abdominal aortic aneurysms in adults.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11374518

• Vascular smooth muscle cell ferroptosis and abdominal aortic aneurysm

  A study to understand how a specific type of cell death in blood vessel walls may drive abdominal aortic aneurysm and if new targets could prevent rupture.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11373578

• Targeting the Mineralocorticoid Receptor in Blood Vessel Cells to Fight Abdominal Aortic Aneurysm in Women

  Researchers are testing a potential treatment strategy that targets a hormone receptor in blood vessels to slow or prevent abdominal aortic aneurysm in women.

  NIH research University of Kentucky · Lexington, United States · NIH-11364929

• Predicting brain aneurysm growth with advanced 4D MRI and tensor math

  A research project uses 4D flow MRI and new math models to predict how brain aneurysms grow over time, helping doctors decide on safer treatments for people with UIAs.

  NIH research University of California, San Francisco · San Francisco, United States · NIH-11357552

• PERK-blocking treatments to slow or stop abdominal aortic aneurysm progression

  Finding out whether medicines that block a cell stress pathway called PERK can protect the aorta in people with abdominal aortic aneurysm.

  NIH research University of Virginia · Charlottesville, United States · NIH-11348188

• New tiny drugs to keep the aorta strong in Marfan syndrome

  A small study tests new compounds that could keep the aorta from dilating and prevent serious complications in people with Marfan syndrome.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11337519

• PAR2 role in abdominal aortic aneurysm development

  Researchers are studying how a specific receptor (PAR2) in blood vessels might contribute to the development and progression of abdominal aortic aneurysms, with potential pathways to new treatments for people with the condition.

  NIH research University of Cincinnati · Cincinnati, United States · NIH-11332797

• Could vaping increase abdominal aortic aneurysm risk across generations

  This project looks at whether parents' vaping or nicotine exposure can cause biological changes that make their children more likely to develop abdominal aortic aneurysms.

  NIH research Palo Alto Veterans Instit for Research · Palo Alto, United States · NIH-11332766

• Enhanced biochemical monitoring for aortic aneurysm disease

  A new approach uses blood-based biomarkers to diagnose, locate, and track aortic aneurysms so doctors can better time treatment.

  NIH research Univ of North Carolina Chapel Hill · Chapel Hill, United States · NIH-11330287

• Oxidative changes and aortic aneurysms in Marfan syndrome

  This work looks at whether reversing a chemical modification that turns off the enzyme Sirt1 in aortic wall cells can help prevent dangerous aortic enlargement in people with Marfan syndrome.

  NIH research Boston University Medical Campus · Boston, United States · NIH-11328829

• Understanding how protein quality control affects abdominal aortic aneurysm (AAA)

  Researchers are studying how the cell’s protein-cleanup system may drive or protect against abdominal aortic aneurysm, with the goal of finding new ways to prevent progression.

  NIH research Augusta University · Augusta, United States · NIH-11318959

• Biocompatible coating to improve aneurysm devices

  A new biocompatible polymer coating for aneurysm treatment devices is being developed to reduce clotting and improve healing without heavy drug therapy.

  NIH research Aneuvas Technologies, INC. · Flagstaff, UNITED STATES · NIH-11316546

• Deciding when to stop yearly CT scans after repair of an abdominal aortic aneurysm

  This project compares keeping yearly CT scans versus less frequent imaging to help Veterans who had endovascular aortic aneurysm repair avoid unnecessary risks.

  NIH research White River Junction VA Medical Center · White River Junction, UNITED STATES · NIH-11311794

• PCSK9 inhibitors and abdominal aortic aneurysm growth

  A new study asks whether lowering LDL cholesterol with PCSK9 inhibitors can slow the growth of abdominal aortic aneurysms in older adults.

  NIH research University of Pennsylvania · Philadelphia, United States · NIH-11309600

• How aging and aged (senescent) cells may cause brain aneurysm rupture

  This research tests whether removing aging 'senescent' cells can lower the chance that a brain aneurysm will burst for people with intracranial aneurysms.

  NIH research St. Joseph's Hospital and Medical Center · Phoenix, United States · NIH-11308268

• GCN2 and amino acid restriction in abdominal aortic aneurysm

  This project looks at how a cellular stress pathway called GCN2, activated by limiting amino acids, might help slow or prevent abdominal aortic aneurysm in people at risk.

  NIH research Northwestern University · Chicago, United States · NIH-11295475

• Targeted treatments to slow or prevent abdominal aortic aneurysm growth

  Looks at whether blocking a protein called BRD4 in artery muscle cells and delivering therapy directly to the aorta can slow or prevent abdominal aortic aneurysm in people at risk.

  NIH research University of Virginia · Charlottesville, United States · NIH-11295470

• What makes abdominal aortic aneurysms grow and weaken

  Researchers are looking at why the wall of the belly artery weakens and can burst in people with abdominal aortic aneurysms by studying cell survival and the artery's outer layer.

  NIH research University of Missouri-Columbia · Columbia, United States · NIH-11289478

• Gene editing to stop aortic aneurysms in Marfan syndrome

  This project uses precise gene-editing to fix or compensate for faulty FBN1 genes in adults with Marfan syndrome to help prevent dangerous aortic enlargement and tearing.

  NIH research Johns Hopkins University · Baltimore, United States · NIH-11282721

• Using AI and 3D CT scans to predict rupture risk for thoracic aortic aneurysms

  This project uses machine learning plus 3D CT scans to help identify adults with thoracic aortic aneurysms—especially smaller ones—who may be at higher risk of rupture.

  NIH research University of Miami Coral Gables · Coral Gables, United States · NIH-11260144

• Reprogramming blood-vessel lining cells in inherited brain aneurysms

  This project aims to find out whether fixing gene-related changes in the cells that line brain arteries can lower aneurysm risk in people with a family history.

  NIH research Yale University · New Haven, United States · NIH-11258496

• How tiny cell structures (podosomes) may weaken brain arteries and cause aneurysms

  Testing whether podosomes — small structures inside blood vessel cells — make brain arteries weaker and raise the risk of aneurysm rupture for people with or at risk of brain aneurysms.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11252802

• How cells' cleanup of vessel attachments may affect brain aneurysms

  This project looks at whether a cellular cleanup process in blood‑vessel lining cells weakens brain arteries and contributes to aneurysms in people at risk for intracranial aneurysm.

  NIH research University of Texas Hlth Sci Ctr Houston · Houston, United States · NIH-11251817

• Which brain aneurysms are likely to grow or burst

  This project looks at whether differences in artery wall strength and blood flow can point to which people with brain aneurysms are at higher risk of rupture.

  NIH research University of Minnesota · Minneapolis, United States · NIH-11247598

• Cell mechanics and gene switches in thoracic aortic aneurysm

  This project looks at how changes in the way aorta cells sense force and control genes can lead to dangerous enlargement of the chest aorta, aiming to help people with or at risk for thoracic aortic aneurysms.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11245710

• Improved MRI methods to find small brain aneurysms likely to grow

  Using improved MRI scans to find inflammation and shape changes that show which small brain aneurysms may grow in people with unruptured aneurysms.

  NIH research University of Washington · Seattle, United States · NIH-11175416

• Genes behind abdominal aortic aneurysm

  Researchers will use large-scale genetic and tissue data to find genes and biological signals that could help prevent or treat abdominal aortic aneurysms in people at risk.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11161577

• Sex differences in aortic aneurysm and dissection risk and protection

  This project looks at how biological sex and sex hormones affect risk and protection for people with or at risk for aortic aneurysms and dissections using animal models and tissue analyses.

  NIH research Cedars-Sinai Medical Center · Los Angeles, United States · NIH-11159759

• Modeling clotting and blood flow in brain aneurysm treatment

  This project uses computer models of blood flow and platelets to predict clotting and treatment outcomes for people treated for brain aneurysms.

  NIH research University of Washington · Seattle, United States · NIH-11146635

Related topics

Quick answers

How many Aneurysm clinical trials are recruiting right now?

13, as of November 12, 2026. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 14 countries. The most sites are in United States (5 trials), France (3 trials), Germany (2 trials), Netherlands (2 trials), Italy (2 trials). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1, Phase 2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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