Understanding how immune cells affect high blood pressure in the liver
Regulation of portal hypertension through neutrophil-platelet interactions in liver sinusoids
This study is looking at how certain immune cells in the liver might be causing high blood pressure in the portal vein, which can happen in people with chronic liver disease, and it hopes to find new ways to help lower that pressure and improve treatment options for patients.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project ID | NIH-10814212 on NIH RePORTER |
What this research studies
This research investigates the role of neutrophils and platelets in causing portal hypertension, a serious condition related to chronic liver disease. By studying how these immune cells interact within the liver's blood vessels, the researchers aim to uncover new therapeutic strategies to lower portal pressure. The approach involves examining cellular signaling and the formation of structures that contribute to this condition, using advanced laboratory techniques and animal models. Patients with liver disease may benefit from insights gained through this research, potentially leading to new treatments.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals suffering from chronic liver disease who experience portal hypertension.
Not a fit: Patients without liver disease or those not experiencing portal hypertension may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapies that effectively reduce portal hypertension in patients with liver disease.
How similar studies have performed: Previous research has shown promising results in understanding the role of immune cells in liver conditions, suggesting that this approach may lead to significant advancements.
Where this research is happening
Rochester, United States
- Mayo Clinic Rochester — Rochester, United States (Active)
Researchers
- Principal investigator: Hilscher, Moira B — Mayo Clinic Rochester
- Study coordinator: Hilscher, Moira B
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.