Measuring portal pressure in patients with advanced liver disease using endoscopic ultrasound

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This observational study aims to evaluate the effectiveness of endoscopic ultrasound-guided portal pressure gradient (EUS-PPG) measurements compared to traditional hepatic venous pressure gradient (HVPG) assessments in patients with advanced chronic liver disease and portal hypertension. The study will involve measuring portal pressure before and after treatment with non-selective beta blockers (NSBBs) to determine hemodynamic responses and identify factors influencing measurement accuracy. Additionally, the research will explore correlations between pressure measurements and the occurrence of liver-related complications, as well as changes in gut microbiota and elastography parameters. Follow-up visits will be conducted every 2-3 months to monitor patient outcomes.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Patients with newly diagnosed esophago-gastric varices or with high suspicion of CSPH at non-invasive tests (porto- systemic collaterals at imaging, platelet count \<150.000 x mm3, spleen size \>13 cm in the largest axis, alteration of elastography parameters of the liver or spleen)
* naïve to treatment with NSBBs,

Exclusion Criteria:

* Child Pugh \>A6
* Hepatocellular carcinoma
* Portal vein thrombosis

Where it's running

• Policlinico Gemelli IRCCS
  Roma, Italy Recruiting

Study contacts

• Principal investigator: Francesco Santopaolo, MD — Fondazione Policlinico A. Gemelli IRCCS, Rome
• Study coordinator: Francesco Santopaolo, MD
• Email: francesco.santopaolo@policlinicogemelli.it
• Phone: +393492754288

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.