Non-invasive evaluation for patients with portal hypertension receiving TIPS
Official title: Non-invasive Evaluation of Prognostic Parameters for Patients With Transjugular Intrahepatic Portosystemic Shunt (TIPS) Using a Structured Follow up Protocol 2
Run by University Hospital, Bonn · NCT04393519 · Data updated 2026-11-12
This study is testing new ways to monitor patients with portal hypertension who are getting a TIPS procedure to see how well they do afterward.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years to 100 Years |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | University Hospital, Bonn Academic / other |
| Locations | 1 site (Bonn) |
| Status | Recruiting |
| Started | May 12, 2020 |
| Main results expected | December 31, 2030 |
| Study ends | December 31, 2030 |
| Registry record updated | October 5, 2021 |
| Trial ID | NCT04393519 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Ideal candidates are patients with liver cirrhosis who are eligible for TIPS insertion according to established guidelines.
✕Probably not a fit
Patients with contraindications for TIPS will not benefit from this study.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This program evaluates non-invasive prognostic parameters in patients undergoing transjugular intrahepatic portosystemic shunt (TIPS) due to complications from portal hypertension. Patients will be monitored through a structured follow-up program at the University Hospital Bonn, where clinical and laboratory data will be collected and analyzed for their prognostic value. The study aims to enhance understanding of patient outcomes following TIPS procedures using advanced imaging techniques such as echocardiography, CT scans, and MRIs.
Why it matters
Potential benefit: If successful, this study could improve the management and outcomes of patients with portal hypertension undergoing TIPS.
How similar studies have gone: While there have been studies on TIPS, this specific non-invasive evaluation approach is novel and may provide new insights into patient management.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: * Insertion of TIPS according to guidelines Exclusion Criteria: * Contraindication for TIPS
Where it's running
-
University Hospital Bonn
Bonn, Germany Recruiting
Study contacts
- Principal investigator: Michael Praktiknjo, MD — University of Bonn
- Study coordinator: Michael Praktiknjo, MD
- Email: michael.praktiknjo@ukbonn.de
- Phone: +49(0)228-287 15770
Similar studies
Other studies for the same condition or treatment. Recruiting studies are listed first.
-
Endohepatology-based reclassification of treatment indication in high-risk MASLD
This study tests whether an endohepatology assessment can change treatment decisions for adults with high-risk MASLD.
-
Coil-assisted small-diameter stent shunt reduction for refractory HE after TIPS
A coil-assisted, small-diameter covered-stent technique is being tested to see if it can safely and effectively reduce shunt flow and lessen recurrent hepatic encephalopathy in people with a prior TIPS.
-
Austrian PBC Registry
This registry follows adults with primary biliary cholangitis in Austrian centers to see how the disease develops over time and how biomarkers relate to complications and symptoms.
-
4D-Flow MRI to see portal hypertension and TIPS outcomes in cirrhosis
This study tests a noninvasive 4D-Flow MRI method to see if it can safely and reliably reflect portal hypertension and predict outcomes for people with cirrhosis, including those needing a TIPS procedure.
-
Apixaban plus carvedilol to prevent portal-hypertension complications in cirrhosis
This will test whether adding apixaban to carvedilol can help prevent variceal bleeding, portal vein thrombosis, and other portal-hypertension complications in adults with Child-Pugh B cirrhosis.
-
Blood clotting and portal vein changes during TIPS placement in cirrhosis
This project will see how blood clotting in the body and in the portal vein changes in adults with cirrhosis who are having a TIPS placed.
How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.