Noninvasive evaluation of liver pressure and health using advanced imaging techniques
Official title: Noninvasive assessment of portal hypertension and hepatic interstitial pressure with advanced magnetic resonance elastography
Funded at Mayo Clinic Rochester · NIH-11059159 · Data updated 2026-11-12
This study is testing a new, painless way to check liver health and pressure using advanced imaging technology, which could help people with chronic liver disease get better and safer care without needing invasive procedures.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Mayo Clinic Rochester NIH-funded |
| Lab location | 1 site (Rochester, United States) |
| Project start | April 1, 2023 |
| Project end | January 31, 2027 |
| Funding year | 2025 |
| Award (this year) | $310,878 |
| NIH project number | 5R01DK132718-03 |
| Project ID | NIH-11059159 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with chronic liver disease, particularly those at risk for portal hypertension.
✕Less likely to help
Patients with non-liver related health issues or those without chronic liver disease may not benefit from this research.
What this research studies
This research focuses on developing a noninvasive method to assess portal hypertension and liver health using advanced magnetic resonance elastography (MRE). By utilizing a new 3D imaging technique, the study aims to provide a safer and more accessible alternative to the invasive procedures currently used to measure liver pressure. Patients with chronic liver disease will benefit from this innovative approach, which seeks to improve diagnosis and monitoring without the need for skilled operators. The research will systematically evaluate various liver parameters to enhance understanding of liver conditions.
Why it matters
Potential benefit: If successful, this research could lead to earlier and more accurate diagnosis of liver conditions, ultimately improving patient outcomes.
How similar studies have gone: Previous studies have shown promise in using magnetic resonance elastography for liver assessment, indicating that this approach may lead to significant advancements in noninvasive diagnostics.
Where this research is happening
-
Mayo Clinic Rochester
Rochester, United States Active
Researchers
- Principal investigator: Yin, Meng — Mayo Clinic Rochester
- Study coordinator: Yin, Meng
Related research
Other NIH-funded projects on the same topics.
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Noninvasive portal pressure estimation using ultrasound-based subharmonic signals
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-
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A noninvasive ultrasound technique called SHAPE could measure portal vein pressure in people with cirrhosis to help manage complications like variceal bleeding and ascites.
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Understanding how liver injury affects blood flow in portal hypertension
This study is looking into how liver damage affects blood flow in people with portal hypertension, focusing on certain proteins that help control blood flow, so we can better understand the condition and find new ways to treat it.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.