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Clinical trial Recruiting at 1 site Observational Ages 18 and up

Portal hypertension with esophagogastric varices: endoscopic treatment vs. non-endoscopic care

Official title: Assessment of Treatment Outcomes for Esophageal and Gastric Varices Secondary to Portal Hypertension

Run by Shanghai Zhongshan Hospital · NCT07358663 · Data updated 2026-11-12

This study tests whether endoscopic treatment helps people with portal hypertension and varices compared to those who don’t get endoscopic therapy.

Quick facts

Study typeObservational
Ages18 Years and up
SexAll
Enrollment1384 (estimated)
SponsorShanghai Zhongshan Hospital
Academic / other
Drugs / interventionschemotherapy
Locations1 site (Shanghai)
StatusRecruiting
StartedJanuary 20, 2026
Main results expectedDecember 31, 2028
Study endsDecember 31, 2028
Registry record updatedMay 14, 2026
Trial IDNCT07358663 on ClinicalTrials.gov

Is this trial a fit for you?

Likely a good fit

Adults with clinical portal hypertension and esophagogastric varices who have undergone abdominal CT and gastroscopy.

Probably not a fit

Findings may not show a clear advantage of endoscopic treatment for certain etiologies or in patients with advanced liver disease or contraindications to endoscopic procedures.

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This is a single-center, prospective observational cohort that follows patients with portal hypertension and esophagogastric varices. Participants are grouped by whether they receive endoscopic treatment or not, and a range of data including clinical features, serum metabolites, CT imaging, endoscopic images, and liver biopsy pathology are collected for both groups. Patients are monitored for adverse events such as rebleeding, hepatic encephalopathy, ascites, subsequent procedures, and survival outcomes. The study will explore outcomes across different etiologies of portal hypertension and includes real-world treatment patterns and follow-up data. No interventional protocol is described beyond standard endoscopic and non-endoscopic management as observed in routine practice.

Why it matters

Potential benefit: If endoscopic treatment is beneficial, patients could experience reduced rebleeding risk and improved survival related to variceal bleeding.

How similar studies have gone: Prior research in this area has shown mixed results; this study adds real-world, multi-omics data to better understand outcomes.

Who can join: the full rules

Show full inclusion / exclusion criteria 
Inclusion Criteria:

* Clinical diagnosis of portal hypertension with esophagogastric varices.
* Underwent abdominal CT and gastroscopy examinations.

Exclusion Criteria:

* Presence of peptic ulcer, gastric tumor, or other causes of gastrointestinal bleeding confirmed by imaging or gastroscopy.
* CT images of inadequate quality or incomplete medical history data.

Where it's running

  • Zhongshan Hospital, Fudan University
    Shanghai, China     Recruiting

Study contacts

Similar studies

Other studies for the same condition or treatment. Recruiting studies are listed first.

How to take part

  1. Review the eligibility criteria above with your treating physician.
  2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
  3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.
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Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.