Portal hypertension biobank for esophagogastric varices
Official title: Construction of a Biobank for a Specialized Cohort of Portal Hypertension
Run by Shanghai Zhongshan Hospital · NCT07419724 · Data updated 2026-11-12
This project will try to collect clinical data, CT images, and biological samples from people with portal hypertension and esophagogastric varices to support multi-omics studies and better-tailored care.
Quick facts
| Study type | Observational |
|---|---|
| Ages | 18 Years and up |
| Sex | All |
| Enrollment | 1000 (estimated) |
| Sponsor | Shanghai Zhongshan Hospital Academic / other |
| Locations | 1 site (Shanghai, Shanghai Municipality) |
| Status | Recruiting |
| Started | October 16, 2025 |
| Main results expected | December 31, 2028 |
| Study ends | December 31, 2031 |
| Registry record updated | February 19, 2026 |
| Trial ID | NCT07419724 on ClinicalTrials.gov |
Is this trial a fit for you?
✓Likely a good fit
Adults diagnosed with portal hypertension who have esophageal or gastric varices and have undergone adequate abdominal CT at Zhongshan Hospital are ideal candidates.
✕Probably not a fit
People without endoscopic or imaging evidence of varices, with poor-quality CT scans, or incomplete medical records are not eligible and unlikely to benefit.
A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.
What this trial studies
This observational biobank at Zhongshan Hospital will enroll patients with portal hypertension complicated by esophagogastric varices who have undergone abdominal CT. The program will link clinical records, endoscopic treatment data, radiology images, and biological samples for genomics, metabolomics, radiomics, and gut microbiota analysis. Patients without varices or with inadequate CT quality or incomplete records will be excluded to ensure data integrity. The goal is to enable more precise stratification and understanding of both cirrhotic and non-cirrhotic portal hypertension.
Why it matters
Potential benefit: If successful, the biobank could help develop personalized diagnostic tools and treatment strategies that reduce rebleeding and mortality from variceal bleeding.
How similar studies have gone: Endoscopic therapy has improved outcomes for variceal bleeding, but creating a multi-omics biobank to drive individualized management is relatively new and has limited published success to date.
Who can join: the full rules
Show full inclusion / exclusion criteria
Inclusion Criteria: 1. Clinically diagnosed with portal hypertension complicated by esophagogastric varices. 2. Underwent abdominal CT examination Exclusion Criteria: 1. Imaging or endoscopic evidence demonstrating absence of esophageal and/or gastric varices. 2. CT image quality not meeting requirements or incomplete medical history data.
Where it's running
-
Zhongshan Hospital, Fudan University
Shanghai, Shanghai Municipality, China Recruiting
Study contacts
- Study coordinator: Xiaoquan Huang, M.D.
- Email: huang.xiaoquan@zs-hospital.sh.cn
- Phone: 86-18801733835
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How to take part
- Review the eligibility criteria above with your treating physician.
- Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
- Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.