Condition

Multimorbidity clinical trials and research

• 10Clinical trials
• 49NIH research projects
• 1New in 30 days
• 8Countries

Newest Multimorbidity clinical trials

All recruiting trials (10)

• Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty

  This study tests whether higher burden of preoperative multimorbidity affects functional recovery after knee replacement in adults with knee osteoarthritis.

  Recruiting Balikesir Ataturk City Hospital · Balıkesir · NCT07882316

• Integrated care for older adults with major depression and multiple chronic conditions

  This program will test whether a coordinated, person-centered care approach called I-CONNECT helps older adults (65+) with depression or bipolar disorder and at least two long-term physical illnesses feel better and manage their care more easily.

  Recruiting KU Leuven · Leuven · NCT07211750

• Health and heart risk after a kidney transplant

  This project will follow adults who received a kidney transplant at Royal Derby Hospital to see how cardiovascular risk factors and other health conditions change over the first year.

  Recruiting University Hospitals of Derby and Burton NHS Foundation Trust · Derby, Derbyshire · NCT07205692

• Annual Wellness Visits with or without GRACE support for older adults with complex needs

  This project will see if adding the GRACE geriatric care approach to Medicare Annual Wellness Visits helps older adults with complex needs and their caregivers stay healthier and avoid hospital visits.

  Recruiting Massachusetts General Hospital · Derby, Connecticut and 3 other locations · NCT07166861

• Health Chat for lifestyle planning in people with multiple cardiometabolic conditions

  This program tests whether a 12-week face-to-face and WeChat-based Health Chat can help adults with two or more cardiometabolic conditions improve lifestyle habits and health.

  Recruiting at 3 sites The University of Hong Kong · Suzhou, Jiangsu and 2 other locations · NCT07158697

• Understanding the relationship between sleep disordered breathing and multiple health conditions

  This study is trying to see how sleep problems affect people's overall health and quality of life by looking at different health conditions in patients with sleep disordered breathing.

  Recruiting Xiangya Hospital of Central South University · Changsha · NCT06755840

• Fisetin for healthy young adults and older patients with multiple chronic conditions

  This pilot will test a short two-day course of the senolytic compound fisetin in healthy young volunteers and hospitalized older patients with multiple chronic diseases to see how it is absorbed and whether it is safe.

  Recruiting Phase 1/2 Hvidovre University Hospital · Hvidovre · NCT06431932

• Telerehabilitation program for veterans with complex health conditions

  This study tests a new online rehabilitation program for older veterans with multiple health issues to see if it helps them improve their physical activity and overall health better than standard education.

  Recruiting VA Office of Research and Development · Aurora, Colorado · NCT06288438

• Wearable activity signatures to spot risk of additional chronic conditions

  This project tests whether wearable sensors can find activity patterns that predict new chronic conditions in people who already have chronic diseases.

  Recruiting University Hospital, Clermont-Ferrand · Clermont-Ferrand · NCT05578495

• Improving medication management for patients with multiple long-term conditions

  This study is trying to improve how medications are managed for people with multiple health conditions when they leave the hospital, by working with patients, their families, and healthcare workers.

  Recruiting Oslo University College · Oslo · NCT05421143

NIH-funded research (newest 40 of 49)

Early-stage science funded by the US National Institutes of Health. Most of these projects don't enroll patients, but they show what is being worked on.

• Integrated Heart Health: A HEARTS-based approach to hypertension and diabetes in Guatemala

  A study tests a team-based, stepwise care model to improve blood pressure and blood sugar control for people with both hypertension and diabetes in Guatemala.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11637221

• M-CaRE: Mobile clinics and a smart heart-lung care tool for multimorbidity

  A mobile, multilingual tool plus community health workers will help screen and manage high blood pressure and COPD in diverse adult patients, especially in underserved areas.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11623182

• Alcohol and HIV interaction driving lung and liver damage through cell signals

  This program explores how alcohol worsens lung and liver problems in people with HIV by affecting cell signals that travel between organs.

  NIH research Emory University · Atlanta, United States · NIH-11617735

• Addressing heart disease risk with HIV care in Nigeria

  A plan to bring heart-disease prevention and treatment into HIV care for people living with HIV in Nigeria.

  NIH research New York University School of Medicine · New York, United States · NIH-11541966

• Understanding how care teams connect to better care for older adults with ADRD and multiple health problems

  This grant tests how the way clinicians work together (their network) affects care quality and outcomes for older adults with Alzheimer's or related dementias and multiple health issues.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11539223

• MADIVA: Using digital tools to study multimorbidity in Africa

  A hosted research program in Africa is building advanced data resources and language-model based tools to study how multiple diseases and aging affect people in rural South Africa and urban Kenya.

  NIH research Wits Health Consortium (Pty), LTD · Parktown, South Africa · NIH-11515025

• Communicating uncertainty in care for children with multiple health issues

  Aimed at helping families understand the uncertain risks and benefits of different treatments for kids with complex medical needs.

  NIH research Utah State Higher Education System--University of Utah · Salt Lake City, United States · NIH-11450812

• Medications for opioid use disorder in older adults with multiple health issues

  This project looks at how older adults living with opioid use disorder and multiple chronic conditions respond to medications for opioid use disorder.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11447399

• HIV aging, thinking skills, and everyday function in South Africa

  A long-term study will help understand how aging with HIV and ART affects thinking, memory, physical abilities, and overall health in South Africa.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11399331

• Digital tools to understand multiple health problems in African communities

  This project uses clinic records, long-term health surveys, and genetics to learn how people in African communities develop and live with multiple health conditions.

  NIH research Wits Health Consortium (Pty), LTD · Parktown, South Africa · NIH-11395803

• Caloric restriction in older adults with obesity: aging markers, frailty, and healthspan

  Aging adults who are obese may benefit from a carefully controlled reduction in calories to see if it improves aging biomarkers and overall health.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11366484

• Addressing heart disease risk in people with HIV in Nigeria

  A patient-friendly plan to help people living with HIV in Nigeria better manage heart disease risk by integrating diabetes and high blood pressure care into HIV clinics.

  NIH research New York University School of Medicine · New York, United States · NIH-11328379

• CAREZ: Bringing HIV and NCD Care Together in Zambia

  A patient-focused program uses community health workers and mobile teams to help people living with HIV in Zambia better manage heart disease and other chronic conditions using a simple, easy-to-follow care package.

  NIH research Centre for Infectious Disease Research · Lusaka, Zambia · NIH-11328299

• Integrated multimorbidity care platform for HIV and depression in Nigeria

  A patient-friendly program in Nigeria will help people living with HIV who also have depression by providing integrated care, support, and digital tools to improve ART adherence.

  NIH research Lagos State University College of Medicine · Lagos, Nigeria · NIH-11326567

• Improving How We Understand and Manage Multimorbidity in Multiple Myeloma

  Aims to use data science to understand how multiple health conditions together affect people with MGUS and multiple myeloma, and to improve care.

  NIH research Washington University · Saint Louis, United States · NIH-11313617

• Using pet dogs to spot household risks for memory and senses loss

  This project looks at whether health and exposure patterns in pet dogs can point to home-based chemical risks that speed up thinking and sensory decline in older adults.

  NIH research University of Wisconsin-Madison · Madison, United States · NIH-11311836

• How multiple health conditions change medicines' effects in older adults

  This project looks at how having multiple chronic illnesses changes the benefits and harms of heart and diabetes medicines for older adults using large Medicare records.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11289313

• M-CaRE: Mobile clinics and a smart care tool for heart and lung health

  A patient-friendly program uses mobile clinics and a simple digital tool to help prevent and treat high blood pressure and COPD for adults, especially in rural areas and underserved communities.

  NIH research Columbia University Health Sciences · New York, United States · NIH-11280593

• Integrating HEARTS care for hypertension and diabetes in Guatemala

  A global health project tests a proven HEARTS delivery model to improve blood pressure and blood sugar control for adults with hypertension and diabetes in Guatemala.

  NIH research University of Michigan at Ann Arbor · Ann Arbor, United States · NIH-11270979

• Improving health outcomes for older adults with osteoarthritis and multiple health conditions

  Aimed at helping adults over 21 with osteoarthritis and other chronic health issues improve how they feel and function through better activity, weight management, and overall care.

  NIH research Dartmouth-Hitchcock Clinic · Lebanon, United States · NIH-11265893

• Making home-based cardiac rehab easier for frail Veterans with heart disease

  A two-part program to help older Veterans with heart disease, multiple medical problems, or frailty start and stick with home-based cardiac rehabilitation.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-11260262

• Virtual peer support for Veterans with multiple chronic conditions

  This project offers virtual peer coaching to help Veterans who have two or more chronic health conditions better manage their care and feel healthier.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11216516

• Understanding the impact of multiple chronic illnesses from patient perspectives

  This study is looking for better ways to understand how living with multiple chronic illnesses affects both your body and mind, using insights from patients to create personalized tools that reflect your unique experiences, starting with pediatric cancer survivors and expanding to others like those with sickle cell dis

  NIH research St. Jude Children's Research Hospital · Memphis, United States · NIH-11146435

• Using data science to improve health management in Africa

  This study is all about helping nurses and clinic managers in South Africa and Kenya use easy-to-understand tools to track health data, so they can better manage patients with multiple health issues, even if they don't have a background in data science.

  NIH research Wits Health Consortium (Pty), LTD · Parktown, South Africa · NIH-11127794

• Understanding Immune Cells in Long-Term Inflammation and Multiple Health Conditions

  This research explores how specific immune cells called T helper cells contribute to long-term inflammation and the development of multiple health conditions in older adults.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-11126880

• Impairment and multiple health conditions in people aging with HIV on ART in South Africa

  Researchers will measure how aging and long-term HIV treatment relate to thinking, memory, movement, and other health problems in adults living with HIV in South Africa.

  NIH research Harvard University D/b/a Harvard School of Public Health · Boston, United States · NIH-11115832

• Primary care that matches Veterans' personal priorities and values

  This project will develop and try a VA primary care approach to help Veterans with multiple chronic conditions bring their personal values into medical decisions so care focuses on what matters most to them.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-11097199

• How alcohol affects lung and liver health in people with HIV

  This study is looking at how drinking alcohol might affect the health of people living with HIV, especially how it could make lung and liver problems worse, so we can find better ways to help manage their overall health.

  NIH research Emory University · Atlanta, United States · NIH-11085643

• A model to understand health challenges for older adults living with HIV

  This study is looking at the health issues older adults with HIV face, especially the risk of dementia, and aims to create a helpful model to find ways to improve their quality of life with personalized care strategies.

  NIH research Massachusetts General Hospital · Boston, United States · NIH-11057631

• Understanding the links between sepsis, aging, and healthcare access in the U.S.

  This study looks at how things like age, other health issues, and access to good healthcare can affect the risk of getting sepsis, with the hope of finding ways to help people stay healthier and get better care.

  NIH research University of Pittsburgh at Pittsburgh · Pittsburgh, United States · NIH-11055992

• Optimizing blood pressure medications to prevent age-related health issues.

  This study is looking at how social factors affect the safe use of blood pressure medications to help older adults stay healthy and possibly prevent issues like Alzheimer's and heart problems, so that patients can better understand how to use their medications effectively.

  NIH research University of Utah · Salt Lake City, United States · NIH-11017772

• Understanding how multiple health conditions affect medication in older adults

  This study looks at how having more than one health issue affects how well medications work and their safety for older adults, with the hope of finding better ways to treat them based on their individual health needs.

  NIH research Rutgers Biomedical and Health Sciences · Newark, UNITED STATES · NIH-11014351

• Investigating pain and medication interactions in older adults at risk for opioid issues

  This study is looking at how older adults with ongoing pain and other health issues might be at risk for problems with opioid use, and it aims to find ways to keep them safe while managing their pain.

  NIH research Ohio State University · Columbus, UNITED STATES · NIH-11012319

• Exploring how psychiatric conditions affect anticoagulation treatment in patients with atrial fibrillation

  This study is looking at how older adults with multiple mental health conditions manage their blood-thinning medication for heart issues, and it aims to understand their experiences and challenges to improve their care.

  NIH research Northeastern University · Boston, United States · NIH-11010781

• Improving access to cardiac rehabilitation for older veterans with multiple health issues

  This study is looking to help veterans with heart issues get better support for their recovery by creating a personalized plan that makes it easier for them to participate in heart rehab programs from home.

  NIH research Veterans Health Administration · Pittsburgh, United States · NIH-11007156

• Understanding how price transparency tools can help patients with multiple health conditions manage medication costs

  This study is looking at how tools that show medication prices can help doctors support older adults with multiple health issues in paying for their medicines, making it easier for them to stick to their treatment plans and stay healthy.

  NIH research Duke University · Durham, United States · NIH-11000274

• Improving care for people with both Medicare and Medicaid who have complex health needs.

  This study is looking at ways to make healthcare better for people who have both Medicare and Medicaid, especially those dealing with multiple health problems or conditions like dementia, by testing new care plans that help coordinate services and make things easier for patients.

  NIH research Harvard School of Public Health · Boston, United States · NIH-10944172

• Using telehealth to provide peer support for Veterans with multiple chronic conditions

  This study is all about helping Veterans with multiple health issues by connecting them with trained peers through online meetings, so they can get support and advice on managing their health and sticking to their treatments, making it easier for them to take care of themselves and feel better overall.

  NIH research VA Puget Sound Healthcare System · Seattle, United States · NIH-10942077

• Understanding and improving muscle recovery in older Veterans after hospital stays

  This study is looking at ways to help older Veterans who have trouble rebuilding their muscle strength after being in the hospital, by figuring out what causes muscle loss and finding early ways to keep their muscles healthy.

  NIH research VA Salt Lake City Healthcare System · Salt Lake City, United States · NIH-10917686

• The role of T helper cells in chronic inflammation and multiple diseases in older adults

  This study is looking at how certain immune cells called T helper cells can cause ongoing inflammation and contribute to health issues like heart disease, diabetes, cancer, and Alzheimer's in older adults, with the goal of finding better treatments to reduce inflammation.

  NIH research Wake Forest University Health Sciences · Winston-Salem, United States · NIH-10904014

Related topics

Quick answers

How many Multimorbidity clinical trials are recruiting right now?

10, as of November 12, 2026. 1 of them was first registered in the last 30 days. We update this list each time we refresh our data from ClinicalTrials.gov.

Where are these trials running?

In 8 countries. The most sites are in United States (2 trials), China (2 trials), Denmark (1 trial), Turkey (Türkiye) (1 trial), Norway (1 trial). Each study page lists its sites and which ones are recruiting.

What phases are they in?

Phase 1/2: 1. Trials with no phase listed are usually device, behavioural or observational studies.

How do I join one?

Open a study, check the "Is this trial a fit for you?" section, then contact the study team listed on the page. They will ask a few screening questions. Asking is free and does not commit you to anything. Talk it over with your doctor first.

Find the studies that fit you

A list is a starting point. Tell us your situation in your own words and we'll rank the studies that match and explain why. It's free and needs no account.

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