Impairment and multiple health conditions in people aging with HIV on ART in South Africa
Official title: Project 3 - Impairment and multimorbidity among people aging with HIV and ART in South Africa
Funded at Harvard University D/b/a Harvard School of Public Health · NIH-11115832 · Data updated 2026-11-12
Researchers will measure how aging and long-term HIV treatment relate to thinking, memory, movement, and other health problems in adults living with HIV in South Africa.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Harvard University D/b/a Harvard School of Public Health NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 15, 2013 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $96,687 |
| NIH project number | 5P01AG041710-11 |
| Project ID | NIH-11115832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates are adults (21 years and older) in South Africa who are living with HIV and receiving antiretroviral therapy, especially older adults in high-HIV-prevalence communities.
✕Less likely to help
People without HIV, children, or individuals not on ART are unlikely to directly benefit from participation in this project.
What this research studies
You would be part of a long-term effort to see how HIV and years on antiretroviral therapy affect thinking, physical ability, and other chronic health conditions as people grow older. The team will collect medical histories, cognitive and physical tests, and biological markers and link these with population data to estimate how common different problems are. They will compare people living with HIV to those without HIV to learn which issues are tied to infection or treatment. This work builds on prior HAALSI research in South African communities and follows participants over time to track changes.
Why it matters
Potential benefit: If successful, the results could help clinicians and health systems detect and manage cognitive, physical, and other age-related problems earlier for people aging with HIV in South Africa.
How similar studies have gone: Previous cohort studies have linked HIV and aging to cognitive and physical decline, but large population-level data from South Africa are limited, so parts of this work are novel.
Where this research is happening
-
Harvard University D/b/a Harvard School of Public Health
Boston, United States Active
Researchers
- Principal investigator: Barnighausen, Till — Harvard University D/b/a Harvard School of Public Health
- Study coordinator: Barnighausen, Till
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.