NIH-funded research P01 program project

HIV aging, thinking skills, and everyday function in South Africa

Official title: Project 3 - Impairment and multimorbidity among people aging with HIV and ART in South Africa

Funded at Harvard University D/b/a Harvard School of Public Health · NIH-11399331 · Data updated 2026-11-12

A long-term study will help understand how aging with HIV and ART affects thinking, memory, physical abilities, and overall health in South Africa.

Quick facts

Grant typeP01 program project
Study typeNIH-funded research
Funding institutionHarvard University D/b/a Harvard School of Public Health
NIH-funded
Lab location1 site (Boston, United States)
Project startSeptember 15, 2013
Project endMay 31, 2028
Funding year2026
Award (this year)$129,379
NIH project number5P01AG041710-12
Project IDNIH-11399331 on NIH RePORTER

Who could benefit from this research

Could help

Adults living with HIV who are aging and receiving ART in South Africa or similar HIV-endemic settings.

Less likely to help

People without HIV or those not aging may not directly benefit from this study.

What this research studies

This project looks at how people living with HIV who are aging and on ART experience cognitive and physical changes, and how these changes relate to other health conditions. Researchers will use data from HAALSI to measure prevalence of cognitive impairment, dementia, and multimorbidity, and identify drivers in HIV-affected communities in South Africa. The study builds on existing partnerships to track health and social outcomes over time, with a focus on policy-relevant findings. Participation involves data collection from adults living with HIV in targeted communities, with attention to consent and confidentiality.

Why it matters

Potential benefit: If successful, it could inform policies and programs to support healthy aging in people living with HIV in Africa.

How similar studies have gone: Previous HAALSI projects have demonstrated the value of longitudinal data for understanding aging and health in HIV populations.

Where this research is happening

  • Harvard University D/b/a Harvard School of Public Health
    Boston, United States
    Active

Researchers

  • Principal investigator: Barnighausen, Till — Harvard University D/b/a Harvard School of Public Health
  • Study coordinator: Barnighausen, Till

Related research

Other NIH-funded projects on the same topics.

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.