Improving How We Understand and Manage Multimorbidity in Multiple Myeloma
Official title: Advancing Research to Develop Improved Methods for Understanding and Managing Multimorbidity in Multiple Myeloma
Funded at Washington University · NIH-11313617 · Data updated 2026-11-12
Aims to use data science to understand how multiple health conditions together affect people with MGUS and multiple myeloma, and to improve care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project start | August 18, 2026 |
| Project end | July 31, 2030 |
| Funding year | 2026 |
| Award (this year) | $346,506 |
| NIH project number | 1R01CA309833-01 |
| Project ID | NIH-11313617 on NIH RePORTER |
Who could benefit from this research
✓Could help
Adults diagnosed with MGUS or multiple myeloma, especially those with obesity, high BMI, or multiple chronic conditions.
✕Less likely to help
Patients without MGUS or MM or without multimorbidity may not directly benefit from this study.
What this research studies
This project will analyze medical history data to see how having several chronic conditions and changes in body weight influence the progression from MGUS to multiple myeloma and survival. It will develop new data-driven methods to map when and how different illnesses occur together in patients over a long time, starting from young adulthood. The goal is to create better, more coordinated care strategies for people with MGUS and multiple myeloma by managing multimorbidity more effectively.
Why it matters
Potential benefit: Could lead to earlier, more personalized care plans that better manage multiple conditions in people at risk for or living with MM.
How similar studies have gone: Prior work suggests data-driven approaches can reveal patterns of multimorbidity that inform care, but this specific MGUS-MM context is relatively novel.
Where this research is happening
-
Washington University
Saint Louis, United States Active
Researchers
- Principal investigator: Chang, Su-Hsin — Washington University
- Study coordinator: Chang, Su-Hsin
Related research
Other NIH-funded projects on the same topics.
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Integrative study of multiple myeloma genetics and disease biology
A team at Dana-Farber and partners is pursuing a long-term project to understand the genetic and molecular drivers of multiple myeloma and how treatments interact with disease biology.
-
Comparative Modeling to Prevent, Detect Early, and Treat Multiple Myeloma
A research team will build and compare computer models to understand how multiple myeloma develops, can be detected earlier, and treated more effectively.
-
How LDL Affects Multiple Myeloma: New Pathways to Keep Remission
A new grant is studying how cholesterol from LDL particles fuels multiple myeloma and how this interaction influences the tumor environment and immune response, with goals to help patients stay in remission.
-
Therapy-induced senescence and immune activation in multiple myeloma
A study in people with multiple myeloma will explore how treatment-related senescence in cancer cells may stimulate the immune system and affect cancer return after standard frontline therapy.
-
BCMA CAR-T enteritis: understanding immune toxicities in multiple myeloma
A broad study to uncover why some CAR-T cell treatments targeting BCMA cause severe intestinal inflammation in people with multiple myeloma.
-
Understanding Drug-Resistant Multiple Myeloma to Stop Relapse
Researchers are studying why some myeloma cells resist treatment and how to create new therapies to prevent relapse.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.