Impact of a DASH diet on kidney stone risk factors
Effect of a DASH-Style Diet on Urinary Risk Factors for Kidney Stone Disease: A Randomized Controlled Trial (CARDIA Ancillary Study)
NA · University of Alabama at Birmingham · NCT06210009
This study tests if following a DASH-style diet can lower the risk of kidney stones in people who have already had them.
Quick facts
| Phase | NA |
|---|---|
| Study type | Interventional |
| Enrollment | 48 (estimated) |
| Ages | 19 Years to 89 Years |
| Sex | All |
| Sponsor | University of Alabama at Birmingham (other) |
| Locations | 1 site (Birmingham, Alabama) |
| Trial ID | NCT06210009 on ClinicalTrials.gov |
What this trial studies
This study aims to evaluate how a DASH-style diet influences urinary risk factors associated with kidney stone disease. Participants diagnosed with kidney stones will be randomized to follow either a DASH-style diet or a Western-style diet for one week, with all meals provided by the Bionutrition Unit. The primary goal is to measure changes in 24-hour urine stone risk parameters, establishing a benchmark for future dietary interventions in kidney stone prevention. This is the first controlled study specifically assessing the DASH dietary pattern in this context.
Who should consider this trial
Good fit: Ideal candidates include individuals aged 19-89 from the Birmingham, AL area with a documented history of kidney stone disease.
Not a fit: Patients currently on dialysis, kidney transplant recipients, or those with certain metabolic disorders may not benefit from this study.
Why it matters
Potential benefit: If successful, this study could provide a dietary intervention that significantly reduces the risk of kidney stone formation.
How similar studies have performed: While dietary interventions for kidney stone prevention have been explored, this specific approach using the DASH diet is novel and has not been previously tested in a controlled setting.
Eligibility criteria
Show full inclusion / exclusion criteria
Inclusion Criteria: * Birmingham, AL area participants of the Coronary Artery Risk Development in Young Adults (CARDIA) study OR patients of the University of Alabama at Birmingham/Kirklin Clinic * Self-reported, documented, and/or prior imaging-based diagnosis of kidney stone disease * Age 19-89 * Any sex * Any race * Able to provide informed consent * Willing to perform 24-hour urine collections * Willing to consume meals prepared by Bionutrition Unit * No food allergies/intolerance to any of the foods in the study menus * Willing to stop for 7 days before and during study: Multivitamins and/or Dietary supplements (including calcium and vitamin C) Exclusion Criteria: * Dialysis * Kidney transplant recipient * Estimated glomerular filtration rate (eGFR) \<60 ml/min/1.73m2 based on historical laboratory measurements * Renal tubular acidosis * Current use of acetazolamide, topiramate, or zonisamide * Primary hyperparathyroidism or history of parathyroidectomy * Hyperthyroidism * Sarcoidosis * Primary hyperoxaluria * Cystinuria * Nephrotic syndrome * Malabsorptive conditions including inflammatory bowel disease or history of malabsorptive surgery (e.g., Roux-en-Y gastric bypass, small bowel resection) * Urinary retention requiring catheterization * Urinary diversion * Pregnancy * Breastfeeding * Malignancy treated in the past 12 months other than non-melanoma skin cancer
Where this trial is running
Birmingham, Alabama
- University of Alabama at Birmingham — Birmingham, Alabama, United States (RECRUITING)
Study contacts
- Study coordinator: Joseph Crivelli, MD
- Email: crivelli@uab.edu
- Phone: 205-996-8765
How to participate
- Review the eligibility criteria above with your treating physician.
- Visit the official trial page on ClinicalTrials.gov for the most current contact information and recruitment status.
- Contact the listed study coordinator or principal investigator to request pre-screening. Pre-screening is free and never obligates you to enroll.
Conditions: Kidney Stone, DASH diet, Western diet