Understanding how oxalate levels affect kidney stone formation
Comprehensive Analysis of Oxalate Homeostasis in Calcium Oxalate Kidney Stone Formers
This study is looking at what causes high levels of oxalate in urine, which can lead to kidney stones, and it will explore how things like diet and gut bacteria might help lower those levels for people who are prone to forming stones.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11000774 on NIH RePORTER |
What this research studies
This research investigates the factors that contribute to high urinary oxalate levels, which are linked to the formation of calcium oxalate kidney stones. It aims to explore how environmental, dietary, and metabolic factors influence oxalate absorption and synthesis in patients who form these stones. The study will also examine the role of a specific gut bacterium, Oxalobacter formigenes, in reducing urinary oxalate levels and its potential for colonization in kidney stone formers. By identifying these mechanisms, the research seeks to improve prevention strategies for kidney stone disease.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals who have a history of calcium oxalate kidney stones.
Not a fit: Patients who do not have a history of kidney stones or those with other types of kidney stones may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better prevention methods for calcium oxalate kidney stones, reducing the incidence and recurrence of this common condition.
How similar studies have performed: Previous research has shown that understanding gut microbiota can influence oxalate metabolism, suggesting potential for success in this area.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Fargue, Sonia — University of Alabama at Birmingham
- Study coordinator: Fargue, Sonia
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.