NIH-funded research R21 grant

A system to help surgeons locate and remove kidney stones during surgery

Official title: A Navigational System for Endoscopic Kidney Stone Surgery

Funded at Vanderbilt University Medical Center · NIH-10833656 · Data updated 2026-11-12

This study is working on a new tool to help surgeons see kidney stones better during surgery, making it easier for them to find and remove the stones, which could lead to fewer repeat surgeries and better results for patients like you.

Quick facts

Grant typeR21 grant
Study typeNIH-funded research
Funding institutionVanderbilt University Medical Center
NIH-funded
Lab location1 site (Nashville, United States)
Project startMay 1, 2023
Project endFebruary 28, 2026
Funding year2024
Award (this year)$190,649
NIH project number5R21DK133742-02
Project IDNIH-10833656 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research are patients scheduled for endoscopic kidney stone surgery.

Less likely to help

Patients with conditions that prevent them from undergoing endoscopic surgery may not benefit from this research.

What this research studies

This research aims to develop a navigational system that enhances the ability of surgeons to visualize and locate kidney stones during endoscopic surgery. By addressing challenges such as blood and debris obscuring the view, the system will utilize advanced imaging techniques to create a clearer picture of the kidney's anatomy. The goal is to improve the accuracy of stone localization and tracking, ultimately leading to better surgical outcomes and reducing the need for repeat procedures. Patients undergoing kidney stone surgery may benefit from this innovative approach that aims to achieve a stone-free status more effectively.

Why it matters

Potential benefit: If successful, this research could significantly reduce the incidence of repeat surgeries and complications related to kidney stones.

How similar studies have gone: Previous research has shown promise in using advanced imaging and navigation systems in surgical procedures, indicating potential success for this approach.

Where this research is happening

  • Vanderbilt University Medical Center
    Nashville, United States
    Active

Researchers

  • Principal investigator: Kavoussi, Nicholas L — Vanderbilt University Medical Center
  • Study coordinator: Kavoussi, Nicholas L

Related research

Other NIH-funded projects on the same topics.

  • Uromodulin and peptides as new targets in kidney stone biology

    This NIH grant explores how a urine protein called uromodulin and its peptide pieces influence calcium oxalate kidney stones, using dogs and human biology to understand why stones form and how to prevent them.

    NIH research University of Minnesota · Minneapolis, United States · NIH-11433374

  • Oxalate‑eating probiotic to help prevent kidney stones

    A new probiotic strain is being developed to help prevent calcium oxalate kidney stones by breaking down oxalic acid in the gut.

    NIH research Unlocked Labs INC. · Laramie, United States · NIH-11364194

  • Oxalate and your immune system in kidney stones

    This grant looks at how oxalate in our diet affects kidney stone risk and our immune cells, especially in adults with calcium oxalate stones.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11359754

  • How the kidney channel claudin‑2 affects calcium balance and calcium kidney stones

    This project looks at how a kidney channel called claudin‑2 helps keep calcium from building up and forming calcium kidney stones.

    NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11296431

  • Oxalate balance in people with calcium oxalate kidney stones

    This project will find out why some adults make or absorb extra oxalate that increases the chance of calcium oxalate kidney stones.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11232375

  • A Probiotic to Prevent Kidney Stones

    This project is developing a new probiotic to help people prevent kidney stones by breaking down a key substance called oxalic acid.

    NIH research Unlocked Labs INC. · Laramie, United States · NIH-11170575

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.