Understanding how a protein affects kidney stones using dogs as a model
Leveraging a unique dog model to determine the role of uromodulin in kidney stone disease
This study is looking at how a protein called uromodulin might affect the risk of kidney stones, especially in dogs, to help us understand how it could lead to better ways to prevent kidney stones in people.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Minnesota NIH-funded |
| Lab location | 1 site (Minneapolis, United States) |
| Project ID | NIH-11144694 on NIH RePORTER |
What this research studies
This research investigates the role of a protein called uromodulin in the formation of kidney stones, particularly focusing on calcium oxalate stones. By studying pet dogs, which naturally develop these stones, researchers aim to uncover how genetic variations in uromodulin influence kidney stone risk. The study will explore the cellular and molecular mechanisms involved, including how uromodulin affects kidney function and inflammation related to stone formation. This approach could lead to better prevention strategies for kidney stones in humans.
Who could benefit from this research
Good fit: Ideal candidates for this research are older adults, particularly those aged 65 and over, who are at higher risk for developing kidney stones.
Not a fit: Patients who do not have a history of kidney stones or related urinary disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatments and prevention strategies for kidney stones, reducing pain and healthcare costs for patients.
How similar studies have performed: Previous research has shown promise in using animal models to understand human diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
Minneapolis, United States
- University of Minnesota — Minneapolis, United States (Active)
Researchers
- Principal investigator: Furrow, Eva — University of Minnesota
- Study coordinator: Furrow, Eva
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.