A Probiotic to Prevent Kidney Stones
Oxalate Biodegrading Probiotic for Kidney Stone Prevention
This project is developing a new probiotic to help people prevent kidney stones by breaking down a key substance called oxalic acid.
Quick facts
| Grant type | Sbir 2 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Unlocked Labs INC. NIH-funded |
| Lab location | 1 site (Laramie, United States) |
| Project ID | NIH-11170575 on NIH RePORTER |
What this research studies
Kidney stones, especially those made of calcium oxalate, are often caused by too much oxalic acid in the urine. Current ways to prevent these stones, like changing your diet or drinking more fluids, are hard to stick with, and other medicines can have unwanted side effects. This project is creating a new probiotic that works by breaking down oxalic acid in your gut before it can be absorbed into your body. The goal is to lower the amount of oxalic acid in your urine, offering a safer and easier way to prevent kidney stones.
Who could benefit from this research
Good fit: Patients who frequently form calcium oxalate kidney stones and struggle with current prevention methods might be ideal candidates for future studies.
Not a fit: Patients whose kidney stones are not primarily caused by calcium oxalate or high oxalic acid levels may not receive benefit from this specific approach.
Why it matters
Potential benefit: If successful, this probiotic could offer a new, safe, and easy way to prevent recurrent kidney stones, reducing the need for strict diets or medications with side effects.
How similar studies have performed: This project builds on a successful Phase I, indicating promising initial results for this novel probiotic approach.
Where this research is happening
Laramie, United States
- Unlocked Labs INC. — Laramie, United States (Active)
Researchers
- Principal investigator: Geisler, Christoph — Unlocked Labs INC.
- Study coordinator: Geisler, Christoph
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.