Understanding how oxalate affects kidney stone formation and immune response
Oxalate-Driven Host Responses in Kidney Stone Disease
This study is looking at how eating foods high in oxalate might lead to kidney stones and how it affects kidney health, so if you've had kidney stones before, this research could help find ways to prevent them from coming back.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-11163258 on NIH RePORTER |
What this research studies
This research investigates the relationship between dietary oxalate intake and the formation of calcium oxalate kidney stones, which are a common and painful condition. It aims to understand how high oxalate diets may lead to the formation of crystals in the urine and how this process affects immune responses in the kidneys. By conducting human studies and experimental models, the research will explore the effects of different oxalate levels on kidney health and inflammation. The findings could help identify dietary factors that contribute to kidney stone recurrence.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults who have experienced recurrent calcium oxalate kidney stones.
Not a fit: Patients who have never had kidney stones or those with kidney stones of a different composition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved dietary recommendations and treatments for individuals prone to kidney stones.
How similar studies have performed: Previous research has shown promising results in understanding the impact of dietary factors on kidney stone formation, suggesting that this approach could yield valuable insights.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Mitchell, Tanecia R — University of Alabama at Birmingham
- Study coordinator: Mitchell, Tanecia R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.