Emergency urinary drainage followed by PCNL in obstructive urosepsis

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This prospective study compares outcomes of patients with obstructive urosepsis who receive emergency urinary decompression either by retrograde ureteral stent or by percutaneous nephrostomy, followed by definitive percutaneous nephrolithotomy after infection resolves. Key outcomes include stone-free rate, operative time, blood loss, postoperative complications, hospital stay, and need for additional procedures. All participants have confirmed infection control and will undergo PCNL under general anesthesia, with data collected on surgical parameters and complication grading. Stone-free status will be assessed 2-4 weeks after surgery using NCCT or ultrasound. The study is conducted at Beni-Suef University and aims to inform optimal sequencing and drainage strategy in this high-risk scenario.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Age 18 years or older.
* Presence of renal or proximal ureteral stones.
* Presentation with urosepsis secondary to obstructive urolithiasis.
* Emergency urinary decompression performed by either retrograde ureteral stent (Double-J stent) or percutaneous nephrostomy (PCN).
* Patients scheduled for definitive stone management via percutaneous nephrolithotomy (PCNL) after clinical stabilization and infection resolution.
* Written informed consent obtained prior to enrollment.

Exclusion Criteria:

* Congenital renal anomalies (e.g., horseshoe kidney, ectopic kidney).
* Pregnancy.
* Uncorrectable coagulopathy or bleeding disorders.
* Active, uncontrolled urinary tract infection at the time of definitive PCNL.
* Severe cardiopulmonary comorbidities rendering the patient unfit for surgery or general anesthesia.
* Patients managed definitively by other modalities (e.g., ureteroscopy or ESWL alone).

Where it's running

• Faculty of Medicine, Beni-Suef University
  Banī Suwayf, Beni Suweif Governorate, Egypt Recruiting

Study contacts

• Study coordinator: Mahmoud Abdallah Mahmoud, lecturer
• Email: mahmoud.abdalla@med.bsu.edu.eg
• Phone: 01155361979

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.