Evaluating Ketorolac for reducing symptoms after ureteral stent placement

Is this trial a fit for you?

A plain-English reading of the study's rules. Only the study team can confirm whether you qualify.

What this trial studies

This pilot study aims to assess the effectiveness of pre-operative intravenous Ketorolac in reducing inflammatory responses and stent-related symptoms in patients undergoing ureteral stent placement due to kidney stones. Eligible participants will be randomly assigned to receive either Ketorolac or a saline control before their procedure. The study will also evaluate the feasibility of recruitment and assessment procedures, alongside measuring plasma inflammatory markers at various stages. Follow-up will include a post-operative check-in to monitor patient recovery and adherence to the protocol.

Why it matters

Who can join: the full rules

Inclusion Criteria:

* Over 18 years of age and willing and able to provide informed consent
* Patients with renal urolithiasis planning to undergo ureteral stent placement following ureteroscopic manipulation

Exclusion Criteria:

* Patients requiring a bilateral stone procedure.
* Patients on a chronic non-steroidal anti-inflammatory drugs (NSAIDs) including Aspirin defined as any NSAIDs use for more than fifteen days within thirty days prior to the procedure. Exception: use of daily Aspirin 81 mg is allowed.
* Patients on any steroid therapy.
* Patients with prescription anti-inflammatory drugs.
* Patients with gastrointestinal ulcers.
* Patients with ureteral obstruction or stricture unrelated to stone disease.
* Patients with active urinary tract infection as evidence of untreated positive urine culture obtained prior to the procedure (as part of pre-operative testing).
* Patients with preexisting indwelling ureteral stent
* Patients who are pregnant or lactating.
* Patients with renal or liver impairment.
* Patients with concurrent disease, infection, or co-morbidity that, in the judgment of the investigator, would render the patient inappropriate for enrollment.

Where it's running

• Washington University
  St Louis, Missouri, United States Recruiting

Study contacts

• Principal investigator: Alana Desai, MD — Washington University School of Medicine
• Study coordinator: Alana Desai, MD
• Email: desaia@email.wustl.edu
• Phone: (314)

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How to take part

1. Review the eligibility criteria above with your treating physician.
2. Check the official listing on ClinicalTrials.gov for the latest contact details and recruitment status.
3. Contact the study coordinator or principal investigator to ask for pre-screening. Pre-screening is free and never obligates you to enroll.