Investigating kidney stone disease in patients with ADPKD
Official title: Kidney Stone Disease In ADPKD
Funded at University of Colorado Denver · NIH-10877906 · Data updated 2026-11-12
This study is looking at how kidney stones impact people with a genetic condition called autosomal dominant polycystic kidney disease (ADPKD) and aims to find out how these stones might speed up kidney problems, while also checking if antibiotics play a role in this.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 22, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $491,228 |
| NIH project number | 5R01DK128842-04 |
| Project ID | NIH-10877906 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults diagnosed with autosomal dominant polycystic kidney disease who also experience kidney stone disease.
✕Less likely to help
Patients without autosomal dominant polycystic kidney disease or those who do not have kidney stones may not benefit from this research.
What this research studies
This research focuses on understanding how kidney stone disease affects individuals with autosomal dominant polycystic kidney disease (ADPKD). It aims to identify the relationship between kidney stones and the progression of kidney disease in ADPKD patients. By utilizing advanced data analytics and studying the gut microbiome, the research seeks to uncover the mechanisms that lead to faster kidney function decline in those with both conditions. The study will also explore the impact of antibiotic exposure on kidney stone risk in this population.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for slowing kidney disease progression in ADPKD patients who also suffer from kidney stones.
How similar studies have gone: Previous research has indicated a link between kidney stone disease and kidney function decline, suggesting that this approach may yield valuable insights.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Chonchol, Michel Benjamin — University of Colorado Denver
- Study coordinator: Chonchol, Michel Benjamin
Related research
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A Probiotic to Prevent Kidney Stones
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.