Investigating kidney stone disease in patients with ADPKD
Kidney Stone Disease In ADPKD
This study is looking at how kidney stones impact people with a genetic condition called autosomal dominant polycystic kidney disease (ADPKD) and aims to find out how these stones might speed up kidney problems, while also checking if antibiotics play a role in this.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-10877906 on NIH RePORTER |
What this research studies
This research focuses on understanding how kidney stone disease affects individuals with autosomal dominant polycystic kidney disease (ADPKD). It aims to identify the relationship between kidney stones and the progression of kidney disease in ADPKD patients. By utilizing advanced data analytics and studying the gut microbiome, the research seeks to uncover the mechanisms that lead to faster kidney function decline in those with both conditions. The study will also explore the impact of antibiotic exposure on kidney stone risk in this population.
Who could benefit from this research
Good fit: Ideal candidates for this research are adults diagnosed with autosomal dominant polycystic kidney disease who also experience kidney stone disease.
Not a fit: Patients without autosomal dominant polycystic kidney disease or those who do not have kidney stones may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for slowing kidney disease progression in ADPKD patients who also suffer from kidney stones.
How similar studies have performed: Previous research has indicated a link between kidney stone disease and kidney function decline, suggesting that this approach may yield valuable insights.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Chonchol, Michel Benjamin — University of Colorado Denver
- Study coordinator: Chonchol, Michel Benjamin
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.