NIH-funded research R01 grant

New methods to predict and prevent kidney stone progression

Official title: Novel evidence-accumulation-driven methods for characterizing kidney stone progression

Funded at Ut Southwestern Medical Center · NIH-11004024 · Data updated 2026-11-12

This study is working on creating personalized tools to help people with kidney stones understand their risk of getting more stones and find ways to prevent them from getting worse, so they can enjoy better health.

Quick facts

Grant typeR01 grant
Study typeNIH-funded research
Funding institutionUt Southwestern Medical Center
NIH-funded
Lab location1 site (Dallas, United States)
Project startMarch 1, 2022
Project endDecember 31, 2026
Funding year2025
Award (this year)$611,460
NIH project number5R01DK128237-04
Project IDNIH-11004024 on NIH RePORTER

Who could benefit from this research

Could help

Ideal candidates for this research include individuals who have a history of kidney stones or are at risk for developing them.

Less likely to help

Patients who have never experienced kidney stones or have conditions unrelated to kidney stone disease may not benefit from this research.

What this research studies

This research aims to improve the prevention of kidney stone progression by developing advanced clinical prediction tools and computational algorithms. It focuses on creating patient-specific risk models that take into account different types of kidney stones and their progression. By analyzing existing data and integrating it with electronic health records, the research seeks to identify modifiable risk factors that can help in preventing recurrent kidney stones. Patients may benefit from personalized strategies that could reduce their risk of developing further complications related to kidney stones.

Why it matters

Potential benefit: If successful, this research could lead to more effective prevention strategies for kidney stone disease, reducing pain and healthcare costs for patients.

How similar studies have gone: Previous research has shown promise in using predictive modeling for chronic diseases, indicating that this approach could be effective for kidney stone progression as well.

Where this research is happening

  • Ut Southwestern Medical Center
    Dallas, United States
    Active

Researchers

  • Principal investigator: Liu, Yu-Lun — Ut Southwestern Medical Center
  • Study coordinator: Liu, Yu-Lun

Related research

Other NIH-funded projects on the same topics.

  • Uromodulin and peptides as new targets in kidney stone biology

    This NIH grant explores how a urine protein called uromodulin and its peptide pieces influence calcium oxalate kidney stones, using dogs and human biology to understand why stones form and how to prevent them.

    NIH research University of Minnesota · Minneapolis, United States · NIH-11433374

  • Oxalate‑eating probiotic to help prevent kidney stones

    A new probiotic strain is being developed to help prevent calcium oxalate kidney stones by breaking down oxalic acid in the gut.

    NIH research Unlocked Labs INC. · Laramie, United States · NIH-11364194

  • Oxalate and your immune system in kidney stones

    This grant looks at how oxalate in our diet affects kidney stone risk and our immune cells, especially in adults with calcium oxalate stones.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11359754

  • How the kidney channel claudin‑2 affects calcium balance and calcium kidney stones

    This project looks at how a kidney channel called claudin‑2 helps keep calcium from building up and forming calcium kidney stones.

    NIH research University of Kansas Medical Center · Kansas City, United States · NIH-11296431

  • Oxalate balance in people with calcium oxalate kidney stones

    This project will find out why some adults make or absorb extra oxalate that increases the chance of calcium oxalate kidney stones.

    NIH research University of Alabama at Birmingham · Birmingham, United States · NIH-11232375

  • A Probiotic to Prevent Kidney Stones

    This project is developing a new probiotic to help people prevent kidney stones by breaking down a key substance called oxalic acid.

    NIH research Unlocked Labs INC. · Laramie, United States · NIH-11170575

About this research

  1. This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
  2. Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
  3. For full project details, budget, and progress reports, visit the official NIH RePORTER page.
Last reviewed 2026-11-14 by the Find a Trial editorial team. Information on this page is for educational purposes and is not medical advice. Always consult qualified healthcare professionals about clinical trial participation.