Understanding Kidney Stones in Polycystic Kidney Disease
Official title: Kidney Stone Disease In ADPKD
Funded at University of Colorado Denver · NIH-11138658 · Data updated 2026-11-12
This project explores how kidney stones might affect kidney function in people with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | September 22, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $500,750 |
| NIH project number | 5R01DK128842-05 |
| Project ID | NIH-11138658 on NIH RePORTER |
Who could benefit from this research
✓Could help
Patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD), especially those who also experience kidney stones, are the focus of this research.
✕Less likely to help
Patients without ADPKD or kidney stone disease would likely not directly benefit from this specific research.
What this research studies
This research focuses on Autosomal Dominant Polycystic Kidney Disease (ADPKD), a condition affecting many people in the US. We know that kidney stones are common in ADPKD and may lead to faster kidney function decline. Our team will combine advanced data analysis with studies of gut bacteria (microbiome) and metabolism to understand this connection. We also want to see if antibiotic use increases the risk of kidney stones in this patient group and how imbalances in gut bacteria contribute to stone formation. This work aims to uncover new ways to protect kidney health for those with ADPKD.
Why it matters
Potential benefit: If successful, this work could identify new ways to slow kidney disease progression in ADPKD patients by better managing kidney stones and understanding the role of antibiotics and gut health.
How similar studies have gone: This proposal builds on preliminary data showing a link between kidney stones and faster kidney function loss in ADPKD, suggesting some prior foundational work.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Chonchol, Michel Benjamin — University of Colorado Denver
- Study coordinator: Chonchol, Michel Benjamin
Related research
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A Probiotic to Prevent Kidney Stones
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.